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Association between the TLR2 Arg753Gln polymorphism and the risk of sepsis: a meta-analysis.

Gao JW, Zhang AQ, Wang X, Li ZY, Yang JH, Zeng L, Gu W, Jiang JX - Crit Care (2015)

Bottom Line: However, the results were conflicting.The selection of a fixed or random effects model was made according to a heterogeneity test in total and subgroup analyses.Sensitivity analysis and publication bias test were performed to ensure the reliability of our results.

View Article: PubMed Central - PubMed

Affiliation: State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, China. nutdgjw@163.com.

ABSTRACT

Introduction: Recently, researchers in a number of studies have explored the association between the Toll-like receptor 2 (TLR2) Arg753Gln polymorphism and sepsis risk. However, the results were conflicting. In this meta-analysis, we aimed to confirm the effect of the TLR2 Arg753Gln polymorphism on sepsis risk.

Methods: Relevant records up to 1 June 2015 were retrieved from the PubMed, Embase, and Web of Knowledge databases. The odds ratios with their corresponding 95 % confidence intervals were used to assess the association between the TLR2 Arg753Gln polymorphism and sepsis risk. The selection of a fixed or random effects model was made according to a heterogeneity test in total and subgroup analyses. Sensitivity analysis and publication bias test were performed to ensure the reliability of our results.

Results: A total of 12 studies with aggregate totals of 898 cases and 1517 controls met our inclusion criteria for meta-analysis. There were significant associations between the TLR2 Arg753Gln polymorphism and sepsis risk in overall analyses under two genetic models (the allele comparison and the dominant model). In addition, subgroup analyses based on age group, ethnicity, sepsis type, and source of control also showed a significant effect of the TLR2 Arg753Gln polymorphism on sepsis risk.

Conclusions: Our present meta-analysis supports a direct effect of the TLR2 Arg753Gln polymorphism on sepsis risk, especially in Europeans. The TLR2 Arg753Gln polymorphism might be used as a relevant risk estimate for the development of sepsis. Studies with larger sample sizes and homogeneous groups of patients with sepsis are required for further analysis.

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Related in: MedlinePlus

Flow diagram of study identification. Because the study conducted by McDaniel et al. [29] reported results on populations of different ethnicities, we treated the populations as two separate studies (study 1 and study 2). A total of 12 studies (11 articles) were ultimately included in our meta-analysis.
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Fig1: Flow diagram of study identification. Because the study conducted by McDaniel et al. [29] reported results on populations of different ethnicities, we treated the populations as two separate studies (study 1 and study 2). A total of 12 studies (11 articles) were ultimately included in our meta-analysis.

Mentions: A total of 247 records were identified by using different combinations of search terms in PubMed, Embase, and Web of Knowledge, and 1 record was identified by checking reference lists. After excluding 70 duplications, 149 records were removed for their unmatched titles or abstracts. Full-text reading helped us to remove 18 records (1 record with insufficient genotype data, 11 reviews, 2 records without mutation genotype, and 4 meeting abstracts). The author of record with insufficient genotype data was contacted. However, no answer was received. Ultimately, 12 studies (11 records) [21–31] were included in our meta-analysis according to the inclusion and exclusion criteria we had set. The study selection process is shown in Fig. 1.Fig. 1


Association between the TLR2 Arg753Gln polymorphism and the risk of sepsis: a meta-analysis.

Gao JW, Zhang AQ, Wang X, Li ZY, Yang JH, Zeng L, Gu W, Jiang JX - Crit Care (2015)

Flow diagram of study identification. Because the study conducted by McDaniel et al. [29] reported results on populations of different ethnicities, we treated the populations as two separate studies (study 1 and study 2). A total of 12 studies (11 articles) were ultimately included in our meta-analysis.
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4663740&req=5

Fig1: Flow diagram of study identification. Because the study conducted by McDaniel et al. [29] reported results on populations of different ethnicities, we treated the populations as two separate studies (study 1 and study 2). A total of 12 studies (11 articles) were ultimately included in our meta-analysis.
Mentions: A total of 247 records were identified by using different combinations of search terms in PubMed, Embase, and Web of Knowledge, and 1 record was identified by checking reference lists. After excluding 70 duplications, 149 records were removed for their unmatched titles or abstracts. Full-text reading helped us to remove 18 records (1 record with insufficient genotype data, 11 reviews, 2 records without mutation genotype, and 4 meeting abstracts). The author of record with insufficient genotype data was contacted. However, no answer was received. Ultimately, 12 studies (11 records) [21–31] were included in our meta-analysis according to the inclusion and exclusion criteria we had set. The study selection process is shown in Fig. 1.Fig. 1

Bottom Line: However, the results were conflicting.The selection of a fixed or random effects model was made according to a heterogeneity test in total and subgroup analyses.Sensitivity analysis and publication bias test were performed to ensure the reliability of our results.

View Article: PubMed Central - PubMed

Affiliation: State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, China. nutdgjw@163.com.

ABSTRACT

Introduction: Recently, researchers in a number of studies have explored the association between the Toll-like receptor 2 (TLR2) Arg753Gln polymorphism and sepsis risk. However, the results were conflicting. In this meta-analysis, we aimed to confirm the effect of the TLR2 Arg753Gln polymorphism on sepsis risk.

Methods: Relevant records up to 1 June 2015 were retrieved from the PubMed, Embase, and Web of Knowledge databases. The odds ratios with their corresponding 95 % confidence intervals were used to assess the association between the TLR2 Arg753Gln polymorphism and sepsis risk. The selection of a fixed or random effects model was made according to a heterogeneity test in total and subgroup analyses. Sensitivity analysis and publication bias test were performed to ensure the reliability of our results.

Results: A total of 12 studies with aggregate totals of 898 cases and 1517 controls met our inclusion criteria for meta-analysis. There were significant associations between the TLR2 Arg753Gln polymorphism and sepsis risk in overall analyses under two genetic models (the allele comparison and the dominant model). In addition, subgroup analyses based on age group, ethnicity, sepsis type, and source of control also showed a significant effect of the TLR2 Arg753Gln polymorphism on sepsis risk.

Conclusions: Our present meta-analysis supports a direct effect of the TLR2 Arg753Gln polymorphism on sepsis risk, especially in Europeans. The TLR2 Arg753Gln polymorphism might be used as a relevant risk estimate for the development of sepsis. Studies with larger sample sizes and homogeneous groups of patients with sepsis are required for further analysis.

Show MeSH
Related in: MedlinePlus