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Tomato (Lycopersicon esculentum) Supplementation Induces Changes in Cardiac miRNA Expression, Reduces Oxidative Stress and Left Ventricular Mass, and Improves Diastolic Function.

Pereira BL, Arruda FC, Reis PP, Felix TF, Santos PP, Rafacho BP, Gonçalves AF, Claro RT, Azevedo PS, Polegato BF, Okoshi K, Fernandes AA, Paiva SA, Zornoff LA, Minicucci MF - Nutrients (2015)

Bottom Line: Tomato intake was also associated with up-regulation of miR-107 and miR-486 and down-regulation of miR-350 and miR-872.In conclusion, tomato supplementation induces changes in miRNA expression and reduces oxidative stress.In addition, these alterations may be responsible for CSA reduction and diastolic function improvement.

View Article: PubMed Central - PubMed

Affiliation: Internal Medicine Department, Botucatu Medical School, Univ Estadual Paulista (UNESP), Botucatu 18618-970, Brazil. bruh_leticia@hotmail.com.

ABSTRACT
The aim of this study was to evaluate the effects of tomato supplementation on the normal rat heart and the role of oxidative stress in this scenario. Male Wistar rats were assigned to two groups: a control group (C; n = 16), in which animals received a control diet + 0.5 mL of corn oil/kg body weight/day, and a tomato group (T; n = 16), in which animals received a control diet supplemented with tomato +0.5 mL of corn oil/kg body weight/day. After three months, morphological, functional, and biochemical analyses were performed. Animals supplemented with tomato had a smaller left atrium diameter and myocyte cross-sectional area (CSA) compared to the control group (C group: 474 (415-539); T group: 273 (258-297) µm²; p = 0.004). Diastolic function was improved in rats supplemented with tomato. In addition, lipid hydroperoxide was lower (C group: 267 ± 46.7; T group: 219 ± 23.0 nmol/g; p = 0.039) in the myocardium of rats supplemented with tomato. Tomato intake was also associated with up-regulation of miR-107 and miR-486 and down-regulation of miR-350 and miR-872. In conclusion, tomato supplementation induces changes in miRNA expression and reduces oxidative stress. In addition, these alterations may be responsible for CSA reduction and diastolic function improvement.

No MeSH data available.


Related in: MedlinePlus

Left ventricle collagen type I and III expression.
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nutrients-07-05493-f001: Left ventricle collagen type I and III expression.

Mentions: Morphological data are listed in Table 2. The tomato group had a lower right ventricular weight and RV/BW compared to the control group. There was no difference in the LV weight between the groups. There was also no difference in LV expression of type I and type III collagen (Figure 1). Regarding the CSA, the tomato group had lower values compared to the control group (C group: 474 (415–539) µm2 (n = 6); T group: 273 (258–297) (n = 5) µm2; p = 0.004).


Tomato (Lycopersicon esculentum) Supplementation Induces Changes in Cardiac miRNA Expression, Reduces Oxidative Stress and Left Ventricular Mass, and Improves Diastolic Function.

Pereira BL, Arruda FC, Reis PP, Felix TF, Santos PP, Rafacho BP, Gonçalves AF, Claro RT, Azevedo PS, Polegato BF, Okoshi K, Fernandes AA, Paiva SA, Zornoff LA, Minicucci MF - Nutrients (2015)

Left ventricle collagen type I and III expression.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4663621&req=5

nutrients-07-05493-f001: Left ventricle collagen type I and III expression.
Mentions: Morphological data are listed in Table 2. The tomato group had a lower right ventricular weight and RV/BW compared to the control group. There was no difference in the LV weight between the groups. There was also no difference in LV expression of type I and type III collagen (Figure 1). Regarding the CSA, the tomato group had lower values compared to the control group (C group: 474 (415–539) µm2 (n = 6); T group: 273 (258–297) (n = 5) µm2; p = 0.004).

Bottom Line: Tomato intake was also associated with up-regulation of miR-107 and miR-486 and down-regulation of miR-350 and miR-872.In conclusion, tomato supplementation induces changes in miRNA expression and reduces oxidative stress.In addition, these alterations may be responsible for CSA reduction and diastolic function improvement.

View Article: PubMed Central - PubMed

Affiliation: Internal Medicine Department, Botucatu Medical School, Univ Estadual Paulista (UNESP), Botucatu 18618-970, Brazil. bruh_leticia@hotmail.com.

ABSTRACT
The aim of this study was to evaluate the effects of tomato supplementation on the normal rat heart and the role of oxidative stress in this scenario. Male Wistar rats were assigned to two groups: a control group (C; n = 16), in which animals received a control diet + 0.5 mL of corn oil/kg body weight/day, and a tomato group (T; n = 16), in which animals received a control diet supplemented with tomato +0.5 mL of corn oil/kg body weight/day. After three months, morphological, functional, and biochemical analyses were performed. Animals supplemented with tomato had a smaller left atrium diameter and myocyte cross-sectional area (CSA) compared to the control group (C group: 474 (415-539); T group: 273 (258-297) µm²; p = 0.004). Diastolic function was improved in rats supplemented with tomato. In addition, lipid hydroperoxide was lower (C group: 267 ± 46.7; T group: 219 ± 23.0 nmol/g; p = 0.039) in the myocardium of rats supplemented with tomato. Tomato intake was also associated with up-regulation of miR-107 and miR-486 and down-regulation of miR-350 and miR-872. In conclusion, tomato supplementation induces changes in miRNA expression and reduces oxidative stress. In addition, these alterations may be responsible for CSA reduction and diastolic function improvement.

No MeSH data available.


Related in: MedlinePlus