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Antidepressant Use is Associated with Increased Energy Intake and Similar Levels of Physical Activity.

Jensen-Otsu E, Austin GL - Nutrients (2015)

Bottom Line: Antidepressants have been associated with weight gain, but the causes are unclear.These results suggest increased energy intake and sedentary behavior may contribute to weight gain associated with antidepressant use.Focusing on limiting food intake and sedentary behaviors may be important in mitigating the weight gain associated with antidepressant use.

View Article: PubMed Central - PubMed

Affiliation: Division of Gastroenterology, University of Washington, 1959 NE Pacific Street, Seattle, WA 98195, USA. ejensenotsu@medicine.washington.edu.

ABSTRACT
Antidepressants have been associated with weight gain, but the causes are unclear. The aims of this study were to assess the association of antidepressant use with energy intake, macronutrient diet composition, and physical activity. We used data on medication use, energy intake, diet composition, and physical activity for 3073 eligible adults from the 2005-2006 National Health and Nutrition Examination Survey (NHANES). Potential confounding variables, including depression symptoms, were included in the models assessing energy intake, physical activity, and sedentary behavior. Antidepressant users reported consuming an additional (mean ± S.E.) 215 ± 73 kcal/day compared to non-users (p = 0.01). There were no differences in percent calories from sugar, fat, or alcohol between the two groups. Antidepressant users had similar frequencies of walking or biking, engaging in muscle-strengthening activities, and engaging in moderate or vigorous physical activity. Antidepressant users were more likely to use a computer for ≥2 h/day (OR 1.77; 95% CI: 1.09-2.90), but TV watching was similar between the two groups. These results suggest increased energy intake and sedentary behavior may contribute to weight gain associated with antidepressant use. Focusing on limiting food intake and sedentary behaviors may be important in mitigating the weight gain associated with antidepressant use.

No MeSH data available.


Related in: MedlinePlus

Antidepressant use is associated with increased energy intake (kcal/day) among adult men and women in the 2005–2006 National Health and Nutrition Examination Survey. Adjusted for Patient Health Questionnaire-9 depression score, tobacco/nicotine use, antipsychotic use, use of insulin, use of non-insulin diabetic medications, use of lipid-lowering medications, number of non-psychiatric/non-diabetic medications, self-assessed physical activity level, BMI category, education, race/ethnicity, and age.
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nutrients-07-05489-f001: Antidepressant use is associated with increased energy intake (kcal/day) among adult men and women in the 2005–2006 National Health and Nutrition Examination Survey. Adjusted for Patient Health Questionnaire-9 depression score, tobacco/nicotine use, antipsychotic use, use of insulin, use of non-insulin diabetic medications, use of lipid-lowering medications, number of non-psychiatric/non-diabetic medications, self-assessed physical activity level, BMI category, education, race/ethnicity, and age.

Mentions: After adjusting for all covariates, antidepressant users reported consuming an additional (mean ± S.E.) 215 ± 73 kcal/day compared to non-users (p = 0.01). Similar increases in daily energy intake among antidepressant users were seen in stratified analyses of men and women (Figure 1). Patients taking bupropion had a similar increase in energy intake compared to patients taking other antidepressants and the association of antidepressant use with energy intake was essentially identical when patients taking bupropion were excluded from analysis.


Antidepressant Use is Associated with Increased Energy Intake and Similar Levels of Physical Activity.

Jensen-Otsu E, Austin GL - Nutrients (2015)

Antidepressant use is associated with increased energy intake (kcal/day) among adult men and women in the 2005–2006 National Health and Nutrition Examination Survey. Adjusted for Patient Health Questionnaire-9 depression score, tobacco/nicotine use, antipsychotic use, use of insulin, use of non-insulin diabetic medications, use of lipid-lowering medications, number of non-psychiatric/non-diabetic medications, self-assessed physical activity level, BMI category, education, race/ethnicity, and age.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4663617&req=5

nutrients-07-05489-f001: Antidepressant use is associated with increased energy intake (kcal/day) among adult men and women in the 2005–2006 National Health and Nutrition Examination Survey. Adjusted for Patient Health Questionnaire-9 depression score, tobacco/nicotine use, antipsychotic use, use of insulin, use of non-insulin diabetic medications, use of lipid-lowering medications, number of non-psychiatric/non-diabetic medications, self-assessed physical activity level, BMI category, education, race/ethnicity, and age.
Mentions: After adjusting for all covariates, antidepressant users reported consuming an additional (mean ± S.E.) 215 ± 73 kcal/day compared to non-users (p = 0.01). Similar increases in daily energy intake among antidepressant users were seen in stratified analyses of men and women (Figure 1). Patients taking bupropion had a similar increase in energy intake compared to patients taking other antidepressants and the association of antidepressant use with energy intake was essentially identical when patients taking bupropion were excluded from analysis.

Bottom Line: Antidepressants have been associated with weight gain, but the causes are unclear.These results suggest increased energy intake and sedentary behavior may contribute to weight gain associated with antidepressant use.Focusing on limiting food intake and sedentary behaviors may be important in mitigating the weight gain associated with antidepressant use.

View Article: PubMed Central - PubMed

Affiliation: Division of Gastroenterology, University of Washington, 1959 NE Pacific Street, Seattle, WA 98195, USA. ejensenotsu@medicine.washington.edu.

ABSTRACT
Antidepressants have been associated with weight gain, but the causes are unclear. The aims of this study were to assess the association of antidepressant use with energy intake, macronutrient diet composition, and physical activity. We used data on medication use, energy intake, diet composition, and physical activity for 3073 eligible adults from the 2005-2006 National Health and Nutrition Examination Survey (NHANES). Potential confounding variables, including depression symptoms, were included in the models assessing energy intake, physical activity, and sedentary behavior. Antidepressant users reported consuming an additional (mean ± S.E.) 215 ± 73 kcal/day compared to non-users (p = 0.01). There were no differences in percent calories from sugar, fat, or alcohol between the two groups. Antidepressant users had similar frequencies of walking or biking, engaging in muscle-strengthening activities, and engaging in moderate or vigorous physical activity. Antidepressant users were more likely to use a computer for ≥2 h/day (OR 1.77; 95% CI: 1.09-2.90), but TV watching was similar between the two groups. These results suggest increased energy intake and sedentary behavior may contribute to weight gain associated with antidepressant use. Focusing on limiting food intake and sedentary behaviors may be important in mitigating the weight gain associated with antidepressant use.

No MeSH data available.


Related in: MedlinePlus