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The Ratio of Dietary Branched-Chain Amino Acids is Associated with a Lower Prevalence of Obesity in Young Northern Chinese Adults: An Internet-Based Cross-Sectional Study.

Li YC, Li Y, Liu LY, Chen Y, Zi TQ, Du SS, Jiang YS, Feng RN, Sun CH - Nutrients (2015)

Bottom Line: Dietary BCAA ratio in obese participants was significantly lower than non-obese participants.Further studies indicated that dietary BCAA ratio was inversely associated with 2-h postprandial glucose (2 h-PG) and status of inflammation.In conclusion, a higher ratio of dietary BCAA is inversely associated with prevalence of obesity, postprandial glucose and status of inflammation in young northern Chinese adults.

View Article: PubMed Central - PubMed

Affiliation: Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, Harbin 150086, China. liyanchuan2013@foxmail.com.

ABSTRACT
This study aims to examine the association between the ratio of dietary branched chain amino acids (BCAA) and risk of obesity among young northern Chinese adults. A total of 948 randomly recruited participants were asked to finish our internet-based dietary questionnaire for the Chinese (IDQC). Associations between dietary BCAA ratio and prevalence of overweight/obesity and abdominal obesity were analyzed. Furthermore, 90 subjects were randomly selected to explore the possible mechanism. Dietary BCAA ratio in obese participants was significantly lower than non-obese participants. We found negative correlations between the ratio of dietary BCAA and body mass index (BMI) (r = -0.197, p < 0.001) or waist circumference (r = -0.187, p < 0.001). Compared with those in the first quartile, the multivariable-adjusted OR (95% CI) of the 3rd and 4th quartiles of dietary BCAA ratio for overweight/obesity were 0.508 (0.265-0.972) and 0.389 (0.193-0.783), respectively (all p < 0.05). After stratification by gender, the significance still existed in the 3rd and 4th quartile in males and the 4th quartile in females. For abdominal obesity, the multivariable-adjusted OR (95% CI) of the 3rd and 4th quartile of dietary BCAA ratio were 0.351 (0.145-0.845) and 0.376 (0.161-0.876), respectively (all p < 0.05). This significance was stronger in males. Further studies indicated that dietary BCAA ratio was inversely associated with 2-h postprandial glucose (2 h-PG) and status of inflammation. In conclusion, a higher ratio of dietary BCAA is inversely associated with prevalence of obesity, postprandial glucose and status of inflammation in young northern Chinese adults.

No MeSH data available.


Related in: MedlinePlus

Dietary BCAAs intake of different obese type: HC, healthy control; O/O, overweight/obesity; AO, abdominal obesity; O/O & AO: overweight/obesity & abdominal obesity. (A) overall population, p < 0.05 between HC and O/O; p < 0.05 between O/O and O/O & AO, AO and O/O & AO; p < 0.01 between HC & O/O & AO; (B) male population, p < 0.01 between O/O & AO and other groups; (C) female population, p < 0.01 between HC and O/O & AO, p < 0.05 between O/O and O/O & AO; AO and O/O & AO.
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nutrients-07-05486-f002: Dietary BCAAs intake of different obese type: HC, healthy control; O/O, overweight/obesity; AO, abdominal obesity; O/O & AO: overweight/obesity & abdominal obesity. (A) overall population, p < 0.05 between HC and O/O; p < 0.05 between O/O and O/O & AO, AO and O/O & AO; p < 0.01 between HC & O/O & AO; (B) male population, p < 0.01 between O/O & AO and other groups; (C) female population, p < 0.01 between HC and O/O & AO, p < 0.05 between O/O and O/O & AO; AO and O/O & AO.

Mentions: We firstly performed this comparison to find the differences in dietary BCAA ratios among obese subtypes (healthy control (HC); overweight/obesity (O/O); abdominal obesity (AO); overweight/obesity plus abdominal obesity (O/O & AO)). In the whole population, dietary BCAA ratios for O/O, AO, and O/O & AO groups were all significantly lower than that in the HC group (p < 0.05). Moreover, the dietary BCAA ratio of the O/O & AO group was even lower than those in O/O and AO groups. After stratifying by gender, similar significant differences still exist in both male and female groups. Confounding factors such as dietary intake of carbohydrate, fat, protein, cholesterol and fiber were controlled in this study (Figure 2).


The Ratio of Dietary Branched-Chain Amino Acids is Associated with a Lower Prevalence of Obesity in Young Northern Chinese Adults: An Internet-Based Cross-Sectional Study.

Li YC, Li Y, Liu LY, Chen Y, Zi TQ, Du SS, Jiang YS, Feng RN, Sun CH - Nutrients (2015)

Dietary BCAAs intake of different obese type: HC, healthy control; O/O, overweight/obesity; AO, abdominal obesity; O/O & AO: overweight/obesity & abdominal obesity. (A) overall population, p < 0.05 between HC and O/O; p < 0.05 between O/O and O/O & AO, AO and O/O & AO; p < 0.01 between HC & O/O & AO; (B) male population, p < 0.01 between O/O & AO and other groups; (C) female population, p < 0.01 between HC and O/O & AO, p < 0.05 between O/O and O/O & AO; AO and O/O & AO.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4663614&req=5

nutrients-07-05486-f002: Dietary BCAAs intake of different obese type: HC, healthy control; O/O, overweight/obesity; AO, abdominal obesity; O/O & AO: overweight/obesity & abdominal obesity. (A) overall population, p < 0.05 between HC and O/O; p < 0.05 between O/O and O/O & AO, AO and O/O & AO; p < 0.01 between HC & O/O & AO; (B) male population, p < 0.01 between O/O & AO and other groups; (C) female population, p < 0.01 between HC and O/O & AO, p < 0.05 between O/O and O/O & AO; AO and O/O & AO.
Mentions: We firstly performed this comparison to find the differences in dietary BCAA ratios among obese subtypes (healthy control (HC); overweight/obesity (O/O); abdominal obesity (AO); overweight/obesity plus abdominal obesity (O/O & AO)). In the whole population, dietary BCAA ratios for O/O, AO, and O/O & AO groups were all significantly lower than that in the HC group (p < 0.05). Moreover, the dietary BCAA ratio of the O/O & AO group was even lower than those in O/O and AO groups. After stratifying by gender, similar significant differences still exist in both male and female groups. Confounding factors such as dietary intake of carbohydrate, fat, protein, cholesterol and fiber were controlled in this study (Figure 2).

Bottom Line: Dietary BCAA ratio in obese participants was significantly lower than non-obese participants.Further studies indicated that dietary BCAA ratio was inversely associated with 2-h postprandial glucose (2 h-PG) and status of inflammation.In conclusion, a higher ratio of dietary BCAA is inversely associated with prevalence of obesity, postprandial glucose and status of inflammation in young northern Chinese adults.

View Article: PubMed Central - PubMed

Affiliation: Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, Harbin 150086, China. liyanchuan2013@foxmail.com.

ABSTRACT
This study aims to examine the association between the ratio of dietary branched chain amino acids (BCAA) and risk of obesity among young northern Chinese adults. A total of 948 randomly recruited participants were asked to finish our internet-based dietary questionnaire for the Chinese (IDQC). Associations between dietary BCAA ratio and prevalence of overweight/obesity and abdominal obesity were analyzed. Furthermore, 90 subjects were randomly selected to explore the possible mechanism. Dietary BCAA ratio in obese participants was significantly lower than non-obese participants. We found negative correlations between the ratio of dietary BCAA and body mass index (BMI) (r = -0.197, p < 0.001) or waist circumference (r = -0.187, p < 0.001). Compared with those in the first quartile, the multivariable-adjusted OR (95% CI) of the 3rd and 4th quartiles of dietary BCAA ratio for overweight/obesity were 0.508 (0.265-0.972) and 0.389 (0.193-0.783), respectively (all p < 0.05). After stratification by gender, the significance still existed in the 3rd and 4th quartile in males and the 4th quartile in females. For abdominal obesity, the multivariable-adjusted OR (95% CI) of the 3rd and 4th quartile of dietary BCAA ratio were 0.351 (0.145-0.845) and 0.376 (0.161-0.876), respectively (all p < 0.05). This significance was stronger in males. Further studies indicated that dietary BCAA ratio was inversely associated with 2-h postprandial glucose (2 h-PG) and status of inflammation. In conclusion, a higher ratio of dietary BCAA is inversely associated with prevalence of obesity, postprandial glucose and status of inflammation in young northern Chinese adults.

No MeSH data available.


Related in: MedlinePlus