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Coleus forskohlii Extract Supplementation in Conjunction with a Hypocaloric Diet Reduces the Risk Factors of Metabolic Syndrome in Overweight and Obese Subjects: A Randomized Controlled Trial.

Loftus HL, Astell KJ, Mathai ML, Su XQ - Nutrients (2015)

Bottom Line: Significant reductions to waist and hip circumference (p = 0.02; p = 0.01, respectively) were recorded in both experimental and placebo groups after the 12 week intervention.Furthermore, high density lipoprotein-cholesterol (HDL-C) was significantly increased (p = 0.01) in both groups.The experimental group showed a favorable improvement in insulin concentration and insulin resistance (p = 0.001; 0.01 respectively) compared to the placebo group.

View Article: PubMed Central - PubMed

Affiliation: Centre for Chronic Disease, College of Health and Biomedicine, Victoria University, P.O. BOX 14428 MCMC, Melbourne 8001, Australia. hayley.loftus@live.vu.edu.au.

ABSTRACT
Limited studies have shown that Coleus forskohlii extract may aid in weight management. This randomized, double blind placebo-controlled clinical study assessed the effects of supplementation with C. forskohlii extract on key markers of obesity and metabolic parameters in overweight and obese individuals. Thirty participants completed the trial and they were randomly assigned to receive either 250 mg of C. forskohlii extract (n = 15) or a placebo twice daily for 12 weeks. All participants were advised to follow a hypocaloric diet throughout the study. Body weight, body mass index (BMI), waist and hip circumference, and waist to hip ratio, were monitored fortnightly. Dietary intake was assessed at the baseline and weeks 4, 8 and 12. Appetite was assessed using visual analogue scales and blood samples were analyzed for plasma lipids, ghrelin, leptin, glucose and insulin at the baseline and end of the intervention. Significant reductions to waist and hip circumference (p = 0.02; p = 0.01, respectively) were recorded in both experimental and placebo groups after the 12 week intervention. Furthermore, high density lipoprotein-cholesterol (HDL-C) was significantly increased (p = 0.01) in both groups. The experimental group showed a favorable improvement in insulin concentration and insulin resistance (p = 0.001; 0.01 respectively) compared to the placebo group. These findings suggest that C. forskohlii extract in conjunction with a hypocaloric diet may be useful in the management of metabolic risk factors.

No MeSH data available.


Related in: MedlinePlus

Change in insulin resistance over the intervention period. Values are expressed as mean ± SEM. * p < 0.05, compared with placebo group.
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nutrients-07-05483-f004: Change in insulin resistance over the intervention period. Values are expressed as mean ± SEM. * p < 0.05, compared with placebo group.

Mentions: Table 3 shows the results of metabolic parameters at the baseline and end of the intervention. Supplementation with C. forskohlii extract for 12 weeks significantly reduced (p = 0.001) insulin concentration compared with the control group (Figure 3). Consistently, there was a significant difference observed (p = 0.01) in HOMA-IR between the experimental and control group after the 12-week intervention (Figure 4). HDL-C was significantly increased (p = 0.01) at week 12 compared to baseline in both groups. No significant differences were observed for blood glucose, TG, TC, HDL to LDL-C ratio, ghrelin or leptin in either group after the 12-week intervention.


Coleus forskohlii Extract Supplementation in Conjunction with a Hypocaloric Diet Reduces the Risk Factors of Metabolic Syndrome in Overweight and Obese Subjects: A Randomized Controlled Trial.

Loftus HL, Astell KJ, Mathai ML, Su XQ - Nutrients (2015)

Change in insulin resistance over the intervention period. Values are expressed as mean ± SEM. * p < 0.05, compared with placebo group.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4663611&req=5

nutrients-07-05483-f004: Change in insulin resistance over the intervention period. Values are expressed as mean ± SEM. * p < 0.05, compared with placebo group.
Mentions: Table 3 shows the results of metabolic parameters at the baseline and end of the intervention. Supplementation with C. forskohlii extract for 12 weeks significantly reduced (p = 0.001) insulin concentration compared with the control group (Figure 3). Consistently, there was a significant difference observed (p = 0.01) in HOMA-IR between the experimental and control group after the 12-week intervention (Figure 4). HDL-C was significantly increased (p = 0.01) at week 12 compared to baseline in both groups. No significant differences were observed for blood glucose, TG, TC, HDL to LDL-C ratio, ghrelin or leptin in either group after the 12-week intervention.

Bottom Line: Significant reductions to waist and hip circumference (p = 0.02; p = 0.01, respectively) were recorded in both experimental and placebo groups after the 12 week intervention.Furthermore, high density lipoprotein-cholesterol (HDL-C) was significantly increased (p = 0.01) in both groups.The experimental group showed a favorable improvement in insulin concentration and insulin resistance (p = 0.001; 0.01 respectively) compared to the placebo group.

View Article: PubMed Central - PubMed

Affiliation: Centre for Chronic Disease, College of Health and Biomedicine, Victoria University, P.O. BOX 14428 MCMC, Melbourne 8001, Australia. hayley.loftus@live.vu.edu.au.

ABSTRACT
Limited studies have shown that Coleus forskohlii extract may aid in weight management. This randomized, double blind placebo-controlled clinical study assessed the effects of supplementation with C. forskohlii extract on key markers of obesity and metabolic parameters in overweight and obese individuals. Thirty participants completed the trial and they were randomly assigned to receive either 250 mg of C. forskohlii extract (n = 15) or a placebo twice daily for 12 weeks. All participants were advised to follow a hypocaloric diet throughout the study. Body weight, body mass index (BMI), waist and hip circumference, and waist to hip ratio, were monitored fortnightly. Dietary intake was assessed at the baseline and weeks 4, 8 and 12. Appetite was assessed using visual analogue scales and blood samples were analyzed for plasma lipids, ghrelin, leptin, glucose and insulin at the baseline and end of the intervention. Significant reductions to waist and hip circumference (p = 0.02; p = 0.01, respectively) were recorded in both experimental and placebo groups after the 12 week intervention. Furthermore, high density lipoprotein-cholesterol (HDL-C) was significantly increased (p = 0.01) in both groups. The experimental group showed a favorable improvement in insulin concentration and insulin resistance (p = 0.001; 0.01 respectively) compared to the placebo group. These findings suggest that C. forskohlii extract in conjunction with a hypocaloric diet may be useful in the management of metabolic risk factors.

No MeSH data available.


Related in: MedlinePlus