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Fat Quality Influences the Obesogenic Effect of High Fat Diets.

Crescenzo R, Bianco F, Mazzoli A, Giacco A, Cancelliere R, di Fabio G, Zarrelli A, Liverini G, Iossa S - Nutrients (2015)

Bottom Line: Hepatic functionality, plasma parameters, and oxidative status were also measured.The results show that feeding on safflower/linseed oil diet attenuates the obesogenic effect of high fat diets and ameliorates the blood lipid profile.Conversely, hepatic steatosis and mitochondrial oxidative stress appear to be negatively affected by a diet rich in unsaturated fatty acids.

View Article: PubMed Central - PubMed

Affiliation: Department of Biology, Federico II University, Via Cinthia, 80138 Naples, Italy. rcrescen@unina.it.

ABSTRACT
High fat and/or carbohydrate intake are associated with an elevated risk for obesity and chronic diseases such as diabetes and cardiovascular diseases. The harmful effects of a high fat diet could be different, depending on dietary fat quality. In fact, high fat diets rich in unsaturated fatty acids are considered less deleterious for human health than those rich in saturated fat. In our previous studies, we have shown that rats fed a high fat diet developed obesity and exhibited a decrease in oxidative capacity and an increase in oxidative stress in liver mitochondria. To investigate whether polyunsaturated fats could attenuate the above deleterious effects of high fat diets, energy balance and body composition were assessed after two weeks in rats fed isocaloric amounts of a high-fat diet (58.2% by energy) rich either in lard or safflower/linseed oil. Hepatic functionality, plasma parameters, and oxidative status were also measured. The results show that feeding on safflower/linseed oil diet attenuates the obesogenic effect of high fat diets and ameliorates the blood lipid profile. Conversely, hepatic steatosis and mitochondrial oxidative stress appear to be negatively affected by a diet rich in unsaturated fatty acids.

No MeSH data available.


Related in: MedlinePlus

Percentage molar distribution of fatty acids and peroxidative index (inset) in hepatic mitochondria (A), hepatic tissue (B), and plasma (C) of rats fed lard or safflower-linseed high fat diet. Values are reported as means with their standard errors. n = 8 different rats. * p < 0.05 compared to lard.
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nutrients-07-05480-f005: Percentage molar distribution of fatty acids and peroxidative index (inset) in hepatic mitochondria (A), hepatic tissue (B), and plasma (C) of rats fed lard or safflower-linseed high fat diet. Values are reported as means with their standard errors. n = 8 different rats. * p < 0.05 compared to lard.

Mentions: Mitochondrial fatty acid composition was found to be quite similar between the two groups of rats (Figure 5A). However, some differences were evident in the content of specific fatty acids, such as the monounsaturated fatty acid oleic acid and the omega 6 fatty acids gamma linolenic, arachidonic, and docosapentaenoic, that were found to be significantly decreased, while the omega 3 fatty acids alpha linolenic, eicosapentaenoic, and docosapantaenoic were found to be significantly higher, in S rats compared to L rats (Figure 5A). As for fatty acid composition of liver tissue, a significant decrease was found in palmitoleic, stearic, and oleic acid content, while there was a significant increase in the omega 6 fatty acids linoleic, gamma-linolenic, eicosadienoic, and dihomo-gamma linolenic and in the omega 3 fatty acid docosapentaenoic (Figure 5B), in S rats compared to L rats. Fatty acid composition of plasma revealed a significant decrease in saturated fatty acids myristic and palmitic, together with a significant increase in omega 6 fatty acid linoleic and gamma-linolenic and omega 3 fatty acid eicosapentaenoic, in S rats compared to L rats (Figure 5C). Significantly higher values of PI were found in mitochondria, liver, and plasma samples from S rats compared to L rats (Figure 5).


Fat Quality Influences the Obesogenic Effect of High Fat Diets.

Crescenzo R, Bianco F, Mazzoli A, Giacco A, Cancelliere R, di Fabio G, Zarrelli A, Liverini G, Iossa S - Nutrients (2015)

Percentage molar distribution of fatty acids and peroxidative index (inset) in hepatic mitochondria (A), hepatic tissue (B), and plasma (C) of rats fed lard or safflower-linseed high fat diet. Values are reported as means with their standard errors. n = 8 different rats. * p < 0.05 compared to lard.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4663608&req=5

nutrients-07-05480-f005: Percentage molar distribution of fatty acids and peroxidative index (inset) in hepatic mitochondria (A), hepatic tissue (B), and plasma (C) of rats fed lard or safflower-linseed high fat diet. Values are reported as means with their standard errors. n = 8 different rats. * p < 0.05 compared to lard.
Mentions: Mitochondrial fatty acid composition was found to be quite similar between the two groups of rats (Figure 5A). However, some differences were evident in the content of specific fatty acids, such as the monounsaturated fatty acid oleic acid and the omega 6 fatty acids gamma linolenic, arachidonic, and docosapentaenoic, that were found to be significantly decreased, while the omega 3 fatty acids alpha linolenic, eicosapentaenoic, and docosapantaenoic were found to be significantly higher, in S rats compared to L rats (Figure 5A). As for fatty acid composition of liver tissue, a significant decrease was found in palmitoleic, stearic, and oleic acid content, while there was a significant increase in the omega 6 fatty acids linoleic, gamma-linolenic, eicosadienoic, and dihomo-gamma linolenic and in the omega 3 fatty acid docosapentaenoic (Figure 5B), in S rats compared to L rats. Fatty acid composition of plasma revealed a significant decrease in saturated fatty acids myristic and palmitic, together with a significant increase in omega 6 fatty acid linoleic and gamma-linolenic and omega 3 fatty acid eicosapentaenoic, in S rats compared to L rats (Figure 5C). Significantly higher values of PI were found in mitochondria, liver, and plasma samples from S rats compared to L rats (Figure 5).

Bottom Line: Hepatic functionality, plasma parameters, and oxidative status were also measured.The results show that feeding on safflower/linseed oil diet attenuates the obesogenic effect of high fat diets and ameliorates the blood lipid profile.Conversely, hepatic steatosis and mitochondrial oxidative stress appear to be negatively affected by a diet rich in unsaturated fatty acids.

View Article: PubMed Central - PubMed

Affiliation: Department of Biology, Federico II University, Via Cinthia, 80138 Naples, Italy. rcrescen@unina.it.

ABSTRACT
High fat and/or carbohydrate intake are associated with an elevated risk for obesity and chronic diseases such as diabetes and cardiovascular diseases. The harmful effects of a high fat diet could be different, depending on dietary fat quality. In fact, high fat diets rich in unsaturated fatty acids are considered less deleterious for human health than those rich in saturated fat. In our previous studies, we have shown that rats fed a high fat diet developed obesity and exhibited a decrease in oxidative capacity and an increase in oxidative stress in liver mitochondria. To investigate whether polyunsaturated fats could attenuate the above deleterious effects of high fat diets, energy balance and body composition were assessed after two weeks in rats fed isocaloric amounts of a high-fat diet (58.2% by energy) rich either in lard or safflower/linseed oil. Hepatic functionality, plasma parameters, and oxidative status were also measured. The results show that feeding on safflower/linseed oil diet attenuates the obesogenic effect of high fat diets and ameliorates the blood lipid profile. Conversely, hepatic steatosis and mitochondrial oxidative stress appear to be negatively affected by a diet rich in unsaturated fatty acids.

No MeSH data available.


Related in: MedlinePlus