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Fat Quality Influences the Obesogenic Effect of High Fat Diets.

Crescenzo R, Bianco F, Mazzoli A, Giacco A, Cancelliere R, di Fabio G, Zarrelli A, Liverini G, Iossa S - Nutrients (2015)

Bottom Line: Hepatic functionality, plasma parameters, and oxidative status were also measured.The results show that feeding on safflower/linseed oil diet attenuates the obesogenic effect of high fat diets and ameliorates the blood lipid profile.Conversely, hepatic steatosis and mitochondrial oxidative stress appear to be negatively affected by a diet rich in unsaturated fatty acids.

View Article: PubMed Central - PubMed

Affiliation: Department of Biology, Federico II University, Via Cinthia, 80138 Naples, Italy. rcrescen@unina.it.

ABSTRACT
High fat and/or carbohydrate intake are associated with an elevated risk for obesity and chronic diseases such as diabetes and cardiovascular diseases. The harmful effects of a high fat diet could be different, depending on dietary fat quality. In fact, high fat diets rich in unsaturated fatty acids are considered less deleterious for human health than those rich in saturated fat. In our previous studies, we have shown that rats fed a high fat diet developed obesity and exhibited a decrease in oxidative capacity and an increase in oxidative stress in liver mitochondria. To investigate whether polyunsaturated fats could attenuate the above deleterious effects of high fat diets, energy balance and body composition were assessed after two weeks in rats fed isocaloric amounts of a high-fat diet (58.2% by energy) rich either in lard or safflower/linseed oil. Hepatic functionality, plasma parameters, and oxidative status were also measured. The results show that feeding on safflower/linseed oil diet attenuates the obesogenic effect of high fat diets and ameliorates the blood lipid profile. Conversely, hepatic steatosis and mitochondrial oxidative stress appear to be negatively affected by a diet rich in unsaturated fatty acids.

No MeSH data available.


Related in: MedlinePlus

Liver appearance in rats fed lard (A–D) or safflower-linseed (E–H) high fat diet.
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nutrients-07-05480-f003: Liver appearance in rats fed lard (A–D) or safflower-linseed (E–H) high fat diet.

Mentions: Plasma metabolic characterization evidenced lower cholesterol but higher lipid peroxidation and ALT activity in S rats compared to L rats (Table 3). At variance with plasma lipid profile, livers from S rats had higher lipids, triglycerides, and cholesterol, as well as higher lipid peroxidation, while water content was significantly lower, compared to L rats (Table 3). The different appearance of livers from L and S rats was evident from pictures taken at the time of sacrifice (Figure 3).


Fat Quality Influences the Obesogenic Effect of High Fat Diets.

Crescenzo R, Bianco F, Mazzoli A, Giacco A, Cancelliere R, di Fabio G, Zarrelli A, Liverini G, Iossa S - Nutrients (2015)

Liver appearance in rats fed lard (A–D) or safflower-linseed (E–H) high fat diet.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4663608&req=5

nutrients-07-05480-f003: Liver appearance in rats fed lard (A–D) or safflower-linseed (E–H) high fat diet.
Mentions: Plasma metabolic characterization evidenced lower cholesterol but higher lipid peroxidation and ALT activity in S rats compared to L rats (Table 3). At variance with plasma lipid profile, livers from S rats had higher lipids, triglycerides, and cholesterol, as well as higher lipid peroxidation, while water content was significantly lower, compared to L rats (Table 3). The different appearance of livers from L and S rats was evident from pictures taken at the time of sacrifice (Figure 3).

Bottom Line: Hepatic functionality, plasma parameters, and oxidative status were also measured.The results show that feeding on safflower/linseed oil diet attenuates the obesogenic effect of high fat diets and ameliorates the blood lipid profile.Conversely, hepatic steatosis and mitochondrial oxidative stress appear to be negatively affected by a diet rich in unsaturated fatty acids.

View Article: PubMed Central - PubMed

Affiliation: Department of Biology, Federico II University, Via Cinthia, 80138 Naples, Italy. rcrescen@unina.it.

ABSTRACT
High fat and/or carbohydrate intake are associated with an elevated risk for obesity and chronic diseases such as diabetes and cardiovascular diseases. The harmful effects of a high fat diet could be different, depending on dietary fat quality. In fact, high fat diets rich in unsaturated fatty acids are considered less deleterious for human health than those rich in saturated fat. In our previous studies, we have shown that rats fed a high fat diet developed obesity and exhibited a decrease in oxidative capacity and an increase in oxidative stress in liver mitochondria. To investigate whether polyunsaturated fats could attenuate the above deleterious effects of high fat diets, energy balance and body composition were assessed after two weeks in rats fed isocaloric amounts of a high-fat diet (58.2% by energy) rich either in lard or safflower/linseed oil. Hepatic functionality, plasma parameters, and oxidative status were also measured. The results show that feeding on safflower/linseed oil diet attenuates the obesogenic effect of high fat diets and ameliorates the blood lipid profile. Conversely, hepatic steatosis and mitochondrial oxidative stress appear to be negatively affected by a diet rich in unsaturated fatty acids.

No MeSH data available.


Related in: MedlinePlus