Limits...
Fat Quality Influences the Obesogenic Effect of High Fat Diets.

Crescenzo R, Bianco F, Mazzoli A, Giacco A, Cancelliere R, di Fabio G, Zarrelli A, Liverini G, Iossa S - Nutrients (2015)

Bottom Line: Hepatic functionality, plasma parameters, and oxidative status were also measured.The results show that feeding on safflower/linseed oil diet attenuates the obesogenic effect of high fat diets and ameliorates the blood lipid profile.Conversely, hepatic steatosis and mitochondrial oxidative stress appear to be negatively affected by a diet rich in unsaturated fatty acids.

View Article: PubMed Central - PubMed

Affiliation: Department of Biology, Federico II University, Via Cinthia, 80138 Naples, Italy. rcrescen@unina.it.

ABSTRACT
High fat and/or carbohydrate intake are associated with an elevated risk for obesity and chronic diseases such as diabetes and cardiovascular diseases. The harmful effects of a high fat diet could be different, depending on dietary fat quality. In fact, high fat diets rich in unsaturated fatty acids are considered less deleterious for human health than those rich in saturated fat. In our previous studies, we have shown that rats fed a high fat diet developed obesity and exhibited a decrease in oxidative capacity and an increase in oxidative stress in liver mitochondria. To investigate whether polyunsaturated fats could attenuate the above deleterious effects of high fat diets, energy balance and body composition were assessed after two weeks in rats fed isocaloric amounts of a high-fat diet (58.2% by energy) rich either in lard or safflower/linseed oil. Hepatic functionality, plasma parameters, and oxidative status were also measured. The results show that feeding on safflower/linseed oil diet attenuates the obesogenic effect of high fat diets and ameliorates the blood lipid profile. Conversely, hepatic steatosis and mitochondrial oxidative stress appear to be negatively affected by a diet rich in unsaturated fatty acids.

No MeSH data available.


Related in: MedlinePlus

Percent contribution of lipids, proteins and carbohydrates to total daily energy expenditure (lard = 380 ± 15, safflower-linseed = 410 ± 25 kJ/day × kg0.75) in rats fed lard or safflower-linseed high fat diet. Values are reported as means with their standard errors. n = 8 different rats. * p < 0.05 compared to lard. Horizontal lines indicate the percent of each macronutrient in the diet (carbohydrate = 20.7%, protein = 21.1%, lipid = 58.2%).
© Copyright Policy
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4663608&req=5

nutrients-07-05480-f002: Percent contribution of lipids, proteins and carbohydrates to total daily energy expenditure (lard = 380 ± 15, safflower-linseed = 410 ± 25 kJ/day × kg0.75) in rats fed lard or safflower-linseed high fat diet. Values are reported as means with their standard errors. n = 8 different rats. * p < 0.05 compared to lard. Horizontal lines indicate the percent of each macronutrient in the diet (carbohydrate = 20.7%, protein = 21.1%, lipid = 58.2%).

Mentions: Fuel oxidation was assessed the day before the sacrifice and it was found that S rats had reduced protein oxidation but higher lipid oxidation compared to L rats (Figure 2). In addition, fuel oxidation in S rats almost matched fuel composition of the diet, while in L rats fuel oxidation was lower than fuel composition of the diet for lipids and it was higher for proteins (Figure 2). Therefore, it appears clear that L rats exhibit an impaired metabolic flexibility that exacerbates obesity development.


Fat Quality Influences the Obesogenic Effect of High Fat Diets.

Crescenzo R, Bianco F, Mazzoli A, Giacco A, Cancelliere R, di Fabio G, Zarrelli A, Liverini G, Iossa S - Nutrients (2015)

Percent contribution of lipids, proteins and carbohydrates to total daily energy expenditure (lard = 380 ± 15, safflower-linseed = 410 ± 25 kJ/day × kg0.75) in rats fed lard or safflower-linseed high fat diet. Values are reported as means with their standard errors. n = 8 different rats. * p < 0.05 compared to lard. Horizontal lines indicate the percent of each macronutrient in the diet (carbohydrate = 20.7%, protein = 21.1%, lipid = 58.2%).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4663608&req=5

nutrients-07-05480-f002: Percent contribution of lipids, proteins and carbohydrates to total daily energy expenditure (lard = 380 ± 15, safflower-linseed = 410 ± 25 kJ/day × kg0.75) in rats fed lard or safflower-linseed high fat diet. Values are reported as means with their standard errors. n = 8 different rats. * p < 0.05 compared to lard. Horizontal lines indicate the percent of each macronutrient in the diet (carbohydrate = 20.7%, protein = 21.1%, lipid = 58.2%).
Mentions: Fuel oxidation was assessed the day before the sacrifice and it was found that S rats had reduced protein oxidation but higher lipid oxidation compared to L rats (Figure 2). In addition, fuel oxidation in S rats almost matched fuel composition of the diet, while in L rats fuel oxidation was lower than fuel composition of the diet for lipids and it was higher for proteins (Figure 2). Therefore, it appears clear that L rats exhibit an impaired metabolic flexibility that exacerbates obesity development.

Bottom Line: Hepatic functionality, plasma parameters, and oxidative status were also measured.The results show that feeding on safflower/linseed oil diet attenuates the obesogenic effect of high fat diets and ameliorates the blood lipid profile.Conversely, hepatic steatosis and mitochondrial oxidative stress appear to be negatively affected by a diet rich in unsaturated fatty acids.

View Article: PubMed Central - PubMed

Affiliation: Department of Biology, Federico II University, Via Cinthia, 80138 Naples, Italy. rcrescen@unina.it.

ABSTRACT
High fat and/or carbohydrate intake are associated with an elevated risk for obesity and chronic diseases such as diabetes and cardiovascular diseases. The harmful effects of a high fat diet could be different, depending on dietary fat quality. In fact, high fat diets rich in unsaturated fatty acids are considered less deleterious for human health than those rich in saturated fat. In our previous studies, we have shown that rats fed a high fat diet developed obesity and exhibited a decrease in oxidative capacity and an increase in oxidative stress in liver mitochondria. To investigate whether polyunsaturated fats could attenuate the above deleterious effects of high fat diets, energy balance and body composition were assessed after two weeks in rats fed isocaloric amounts of a high-fat diet (58.2% by energy) rich either in lard or safflower/linseed oil. Hepatic functionality, plasma parameters, and oxidative status were also measured. The results show that feeding on safflower/linseed oil diet attenuates the obesogenic effect of high fat diets and ameliorates the blood lipid profile. Conversely, hepatic steatosis and mitochondrial oxidative stress appear to be negatively affected by a diet rich in unsaturated fatty acids.

No MeSH data available.


Related in: MedlinePlus