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Ameliorating Effect of Akebia quinata Fruit Extracts on Skin Aging Induced by Advanced Glycation End Products.

Shin S, Son D, Kim M, Lee S, Roh KB, Ryu D, Lee J, Jung E, Park D - Nutrients (2015)

Bottom Line: We also found that AQFE inhibits glycation reaction between BSA and glucose.AQFE reduced CML expression and stimulated fibrillin-1 expression in comparison to the methyglyoxal treatment.The overall results suggest that AQFE may work as an anti-skin aging agent by preventing oxidative stress and other complications associated with AGEs formation.

View Article: PubMed Central - PubMed

Affiliation: Biospectrum Life Science Institute, Eines Platz 11th FL, 442-13 Sangdaewon Dong, Seoungnam City, Gyunggi Do 462-807, Korea. biost@biospectrum.com.

ABSTRACT
The accumulation of free radicals and advanced glycation end products (AGEs) in the skin plays a very important role in skin aging. Both are known to interact with each other. Therefore, natural compounds or extracts that possess both antioxidant and antiglycation activities might have great antiageing potential. Akebia quinata fruit extract (AQFE) has been used to treat urinary tract inflammatory disease in traditional Korean and Chinese medicines. In the present study, AQFE was demonstrated to possess antioxidant and antiglycation activity. AQFE protects human dermal fibroblasts (HDFs) from oxidative stress and inhibits cellular senescence induced by oxidative stress. We also found that AQFE inhibits glycation reaction between BSA and glucose. The antiglycation activity of AQFE was dose-dependent. In addition, the antiglycation activity of AQFE was confirmed in a human skin explant model. AQFE reduced CML expression and stimulated fibrillin-1 expression in comparison to the methyglyoxal treatment. In addition, the possibility of the extract as an anti-skin aging agent has also been clinically validated. Our analysis of the crow's feet wrinkle showed that there was a decrease in the depth of deep furrows in RI treated with AQFE cream over an eight-week period. The overall results suggest that AQFE may work as an anti-skin aging agent by preventing oxidative stress and other complications associated with AGEs formation.

No MeSH data available.


Related in: MedlinePlus

Visual improvement of wrinkles in the crow’s feet area with AQFE (0.5%) application for eight weeks. (A) Skin wrinkle images in crow’s feet following application of the test product for eight consecutive weeks (Subject No. 15) (upper; Digital image, lower; 3D image). (B) Changes of skin wrinkle parameters in crow’s feet following application of test product for eight consecutive weeks. (Mean ± SEM. #p <0.05; ##p < 0.01 versus before treatment (0 W)). Ra: arithmetic average roughness; Rz: average roughness; Rmax: maximum roughness; Rp: smoothness depth.
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nutrients-07-05478-f006: Visual improvement of wrinkles in the crow’s feet area with AQFE (0.5%) application for eight weeks. (A) Skin wrinkle images in crow’s feet following application of the test product for eight consecutive weeks (Subject No. 15) (upper; Digital image, lower; 3D image). (B) Changes of skin wrinkle parameters in crow’s feet following application of test product for eight consecutive weeks. (Mean ± SEM. #p <0.05; ##p < 0.01 versus before treatment (0 W)). Ra: arithmetic average roughness; Rz: average roughness; Rmax: maximum roughness; Rp: smoothness depth.

Mentions: A recent study reported that inhibition of AGE formation is involved in the anti-skin aging effect [38]. Therefore, based on the in vitro activities in live human explants, the efficacy of the extract as an anti-skin aging agent was also clinically examined. A formulation containing 0.5% AQFE was applied to the periorbital region of 17 volunteers over eight weeks. Our analysis of the crow’s feet wrinkle showed a decrease in the depth of deep furrows in RI treated with AQFE cream over an eight-week period (p < 0.05) (Figure 6).


Ameliorating Effect of Akebia quinata Fruit Extracts on Skin Aging Induced by Advanced Glycation End Products.

Shin S, Son D, Kim M, Lee S, Roh KB, Ryu D, Lee J, Jung E, Park D - Nutrients (2015)

Visual improvement of wrinkles in the crow’s feet area with AQFE (0.5%) application for eight weeks. (A) Skin wrinkle images in crow’s feet following application of the test product for eight consecutive weeks (Subject No. 15) (upper; Digital image, lower; 3D image). (B) Changes of skin wrinkle parameters in crow’s feet following application of test product for eight consecutive weeks. (Mean ± SEM. #p <0.05; ##p < 0.01 versus before treatment (0 W)). Ra: arithmetic average roughness; Rz: average roughness; Rmax: maximum roughness; Rp: smoothness depth.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4663606&req=5

nutrients-07-05478-f006: Visual improvement of wrinkles in the crow’s feet area with AQFE (0.5%) application for eight weeks. (A) Skin wrinkle images in crow’s feet following application of the test product for eight consecutive weeks (Subject No. 15) (upper; Digital image, lower; 3D image). (B) Changes of skin wrinkle parameters in crow’s feet following application of test product for eight consecutive weeks. (Mean ± SEM. #p <0.05; ##p < 0.01 versus before treatment (0 W)). Ra: arithmetic average roughness; Rz: average roughness; Rmax: maximum roughness; Rp: smoothness depth.
Mentions: A recent study reported that inhibition of AGE formation is involved in the anti-skin aging effect [38]. Therefore, based on the in vitro activities in live human explants, the efficacy of the extract as an anti-skin aging agent was also clinically examined. A formulation containing 0.5% AQFE was applied to the periorbital region of 17 volunteers over eight weeks. Our analysis of the crow’s feet wrinkle showed a decrease in the depth of deep furrows in RI treated with AQFE cream over an eight-week period (p < 0.05) (Figure 6).

Bottom Line: We also found that AQFE inhibits glycation reaction between BSA and glucose.AQFE reduced CML expression and stimulated fibrillin-1 expression in comparison to the methyglyoxal treatment.The overall results suggest that AQFE may work as an anti-skin aging agent by preventing oxidative stress and other complications associated with AGEs formation.

View Article: PubMed Central - PubMed

Affiliation: Biospectrum Life Science Institute, Eines Platz 11th FL, 442-13 Sangdaewon Dong, Seoungnam City, Gyunggi Do 462-807, Korea. biost@biospectrum.com.

ABSTRACT
The accumulation of free radicals and advanced glycation end products (AGEs) in the skin plays a very important role in skin aging. Both are known to interact with each other. Therefore, natural compounds or extracts that possess both antioxidant and antiglycation activities might have great antiageing potential. Akebia quinata fruit extract (AQFE) has been used to treat urinary tract inflammatory disease in traditional Korean and Chinese medicines. In the present study, AQFE was demonstrated to possess antioxidant and antiglycation activity. AQFE protects human dermal fibroblasts (HDFs) from oxidative stress and inhibits cellular senescence induced by oxidative stress. We also found that AQFE inhibits glycation reaction between BSA and glucose. The antiglycation activity of AQFE was dose-dependent. In addition, the antiglycation activity of AQFE was confirmed in a human skin explant model. AQFE reduced CML expression and stimulated fibrillin-1 expression in comparison to the methyglyoxal treatment. In addition, the possibility of the extract as an anti-skin aging agent has also been clinically validated. Our analysis of the crow's feet wrinkle showed that there was a decrease in the depth of deep furrows in RI treated with AQFE cream over an eight-week period. The overall results suggest that AQFE may work as an anti-skin aging agent by preventing oxidative stress and other complications associated with AGEs formation.

No MeSH data available.


Related in: MedlinePlus