Limits...
Celiac Disease Genomic, Environmental, Microbiome, and Metabolomic (CDGEMM) Study Design: Approach to the Future of Personalized Prevention of Celiac Disease.

Leonard MM, Camhi S, Huedo-Medina TB, Fasano A - Nutrients (2015)

Bottom Line: Recent studies however suggest that loss of gluten tolerance can occur at any time in life as a consequence of other environmental stimuli.These include birthing delivery mode, infant feeding, and antibiotic use.Here we describe a prospective, multicenter, longitudinal study of infants at risk for CD which will employ a blend of basic and applied studies to yield fundamental insights into the role of the gut microbiome as an additional factor that may play a key role in early steps involved in the onset of autoimmune disease.

View Article: PubMed Central - PubMed

Affiliation: Center for Celiac Research, Massachusetts General Hospital for Children, Boston, MA 02114, USA. mleonard7@mgh.harvard.edu.

ABSTRACT
In the past it was believed that genetic predisposition and exposure to gluten were necessary and sufficient to develop celiac disease (CD). Recent studies however suggest that loss of gluten tolerance can occur at any time in life as a consequence of other environmental stimuli. Many environmental factors known to influence the composition of the intestinal microbiota are also suggested to play a role in the development of CD. These include birthing delivery mode, infant feeding, and antibiotic use. To date no large-scale longitudinal studies have defined if and how gut microbiota composition and metabolomic profiles may influence the loss of gluten tolerance and subsequent onset of CD in genetically-susceptible individuals. Here we describe a prospective, multicenter, longitudinal study of infants at risk for CD which will employ a blend of basic and applied studies to yield fundamental insights into the role of the gut microbiome as an additional factor that may play a key role in early steps involved in the onset of autoimmune disease.

No MeSH data available.


Related in: MedlinePlus

Celiac Disease Genomic, Environmental, Microbiome, and Metabolomic (CDGEMM) Integrative Multilevel Model to Predict Celiac Disease.
© Copyright Policy
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4663598&req=5

nutrients-07-05470-f003: Celiac Disease Genomic, Environmental, Microbiome, and Metabolomic (CDGEMM) Integrative Multilevel Model to Predict Celiac Disease.

Mentions: The conceptual framework proposed (Figure 3) draws on biological and environmental literature [22,23,24,25] examining the intersection between biomarkers, environmental factors, genetic factors, and individual factors. The onset of loss of tolerance to gluten will be measured as a continuous dependent variable based on levels of tTG IgA. Ultimately the diagnosis of CD will be confirmed by an endoscopy with duodenal biopsy. Given this, we expect to observe the following:(1)


Celiac Disease Genomic, Environmental, Microbiome, and Metabolomic (CDGEMM) Study Design: Approach to the Future of Personalized Prevention of Celiac Disease.

Leonard MM, Camhi S, Huedo-Medina TB, Fasano A - Nutrients (2015)

Celiac Disease Genomic, Environmental, Microbiome, and Metabolomic (CDGEMM) Integrative Multilevel Model to Predict Celiac Disease.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4663598&req=5

nutrients-07-05470-f003: Celiac Disease Genomic, Environmental, Microbiome, and Metabolomic (CDGEMM) Integrative Multilevel Model to Predict Celiac Disease.
Mentions: The conceptual framework proposed (Figure 3) draws on biological and environmental literature [22,23,24,25] examining the intersection between biomarkers, environmental factors, genetic factors, and individual factors. The onset of loss of tolerance to gluten will be measured as a continuous dependent variable based on levels of tTG IgA. Ultimately the diagnosis of CD will be confirmed by an endoscopy with duodenal biopsy. Given this, we expect to observe the following:(1)

Bottom Line: Recent studies however suggest that loss of gluten tolerance can occur at any time in life as a consequence of other environmental stimuli.These include birthing delivery mode, infant feeding, and antibiotic use.Here we describe a prospective, multicenter, longitudinal study of infants at risk for CD which will employ a blend of basic and applied studies to yield fundamental insights into the role of the gut microbiome as an additional factor that may play a key role in early steps involved in the onset of autoimmune disease.

View Article: PubMed Central - PubMed

Affiliation: Center for Celiac Research, Massachusetts General Hospital for Children, Boston, MA 02114, USA. mleonard7@mgh.harvard.edu.

ABSTRACT
In the past it was believed that genetic predisposition and exposure to gluten were necessary and sufficient to develop celiac disease (CD). Recent studies however suggest that loss of gluten tolerance can occur at any time in life as a consequence of other environmental stimuli. Many environmental factors known to influence the composition of the intestinal microbiota are also suggested to play a role in the development of CD. These include birthing delivery mode, infant feeding, and antibiotic use. To date no large-scale longitudinal studies have defined if and how gut microbiota composition and metabolomic profiles may influence the loss of gluten tolerance and subsequent onset of CD in genetically-susceptible individuals. Here we describe a prospective, multicenter, longitudinal study of infants at risk for CD which will employ a blend of basic and applied studies to yield fundamental insights into the role of the gut microbiome as an additional factor that may play a key role in early steps involved in the onset of autoimmune disease.

No MeSH data available.


Related in: MedlinePlus