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Inverse Correlation between Vitamin D and C-Reactive Protein in Newborns.

Tao RX, Zhou QF, Xu ZW, Hao JH, Huang K, Mou Z, Jiang XM, Tao FB, Zhu P - Nutrients (2015)

Bottom Line: Stratified by 25(OH)D levels, per 10 nmol/L increase in 25(OH)D, CRP decreased by 1.42 mg/L (95% CI: 0.90, 1.95) among neonates with 25(OH)D <25.0 nmol/L, and decreased by 0.49 mg/L (95% CI: 0.17, 0.80) among neonates with 25(OH)D between 25.0 nmol/L and 49.9 nmol/L, after adjusting for potential confounders.Among neonates born in winter-spring, neonates with 25(OH)D <25 nmol/L had higher risk of CRP ≥10 mg/L (adjusted OR = 3.06, 95% CI: 2.00, 4.69), compared to neonates with 25(OH)D ≥25 nmol/L.Neonates with vitamin D deficiency had higher risk of exposure to elevated inflammation at birth.

View Article: PubMed Central - PubMed

Affiliation: Department of Gynecology and Obstetrics, Hefei First People's Hospital, Hefei 230001, China. taoruixue.good@163.com.

ABSTRACT
Some studies suggested that adequate vitamin D might reduce inflammation in adults. However, little is known about this association in early life. We aimed to determine the relationship between cord blood 25-hydroxyvitamin D (25(OH)D) and C-reactive protein (CRP) in neonates. Cord blood levels of 25(OH)D and CRP were measured in 1491 neonates in Hefei, China. Potential confounders including maternal sociodemographic characteristics, perinatal health status, lifestyle, and birth outcomes were prospectively collected. The average values of cord blood 25(OH)D and CRP were 39.43 nmol/L (SD = 20.35) and 6.71 mg/L (SD = 3.07), respectively. Stratified by 25(OH)D levels, per 10 nmol/L increase in 25(OH)D, CRP decreased by 1.42 mg/L (95% CI: 0.90, 1.95) among neonates with 25(OH)D <25.0 nmol/L, and decreased by 0.49 mg/L (95% CI: 0.17, 0.80) among neonates with 25(OH)D between 25.0 nmol/L and 49.9 nmol/L, after adjusting for potential confounders. However, no significant association between 25(OH)D and CRP was observed among neonates with 25(OH)D ≥50 nmol/L. Cord blood 25(OH)D and CRP levels showed a significant seasonal trend with lower 25(OH)D and higher CRP during winter-spring than summer-autumn. Stratified by season, a significant linear association of 25(OH)D with CRP was observed in neonates born in winter-spring (adjusted β = -0.11, 95% CI: -0.13, -0.10), but not summer-autumn. Among neonates born in winter-spring, neonates with 25(OH)D <25 nmol/L had higher risk of CRP ≥10 mg/L (adjusted OR = 3.06, 95% CI: 2.00, 4.69), compared to neonates with 25(OH)D ≥25 nmol/L. Neonates with vitamin D deficiency had higher risk of exposure to elevated inflammation at birth.

No MeSH data available.


Related in: MedlinePlus

Associations between cord blood 25(OH)D and CRP, stratified by season. The adjusted linear relation was assessed by multiple linear models in neonates born in winter-spring (A, n = 699) and summer-autumn (B, n = 792). The solid black line denotes the fit of the regression model, the solid grey line denote 95% CI (A,B). The adjusted differences on CRP levels (C) and adjusted ORs of CRP ≥10 mg/L (D) for neonates with 25(OH)D <25 nmol/L were assessed by multiple linear model. Potential confounders included maternal sociodemographic characteristics, perinatal health status, lifestyle, and birth outcomes. Bars represent regression coefficients (C) or ORs (D), with 95% CI.
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nutrients-07-05468-f004: Associations between cord blood 25(OH)D and CRP, stratified by season. The adjusted linear relation was assessed by multiple linear models in neonates born in winter-spring (A, n = 699) and summer-autumn (B, n = 792). The solid black line denotes the fit of the regression model, the solid grey line denote 95% CI (A,B). The adjusted differences on CRP levels (C) and adjusted ORs of CRP ≥10 mg/L (D) for neonates with 25(OH)D <25 nmol/L were assessed by multiple linear model. Potential confounders included maternal sociodemographic characteristics, perinatal health status, lifestyle, and birth outcomes. Bars represent regression coefficients (C) or ORs (D), with 95% CI.

Mentions: Stratification by season was performed to further explore the association of 25(OH)D with CRP. A significant linear association of 25(OH)D with CRP was observed in neonates born in winter-spring, but not summer-autumn. CRP decreased by 1.11 mg/L (95% CI: 0.95, 1.27) per 10 nmol/L increase in 25(OH)D among neonates born in winter-spring after adjusted for potential confounders. Accordingly, neonates with 25(OH)D <25 nmol/L had higher CRP concentrations (adjusted β = 2.39, 95% CI: 1.952, 2.837) and higher risk of CRP ≥10 mg/L (adjusted OR = 3.06, 95% CI: 2.00, 4.69), compared to neonates with 25(OH)D ≥25 nmol/L, when they were born in winter-spring (Figure 4).


Inverse Correlation between Vitamin D and C-Reactive Protein in Newborns.

Tao RX, Zhou QF, Xu ZW, Hao JH, Huang K, Mou Z, Jiang XM, Tao FB, Zhu P - Nutrients (2015)

Associations between cord blood 25(OH)D and CRP, stratified by season. The adjusted linear relation was assessed by multiple linear models in neonates born in winter-spring (A, n = 699) and summer-autumn (B, n = 792). The solid black line denotes the fit of the regression model, the solid grey line denote 95% CI (A,B). The adjusted differences on CRP levels (C) and adjusted ORs of CRP ≥10 mg/L (D) for neonates with 25(OH)D <25 nmol/L were assessed by multiple linear model. Potential confounders included maternal sociodemographic characteristics, perinatal health status, lifestyle, and birth outcomes. Bars represent regression coefficients (C) or ORs (D), with 95% CI.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4663596&req=5

nutrients-07-05468-f004: Associations between cord blood 25(OH)D and CRP, stratified by season. The adjusted linear relation was assessed by multiple linear models in neonates born in winter-spring (A, n = 699) and summer-autumn (B, n = 792). The solid black line denotes the fit of the regression model, the solid grey line denote 95% CI (A,B). The adjusted differences on CRP levels (C) and adjusted ORs of CRP ≥10 mg/L (D) for neonates with 25(OH)D <25 nmol/L were assessed by multiple linear model. Potential confounders included maternal sociodemographic characteristics, perinatal health status, lifestyle, and birth outcomes. Bars represent regression coefficients (C) or ORs (D), with 95% CI.
Mentions: Stratification by season was performed to further explore the association of 25(OH)D with CRP. A significant linear association of 25(OH)D with CRP was observed in neonates born in winter-spring, but not summer-autumn. CRP decreased by 1.11 mg/L (95% CI: 0.95, 1.27) per 10 nmol/L increase in 25(OH)D among neonates born in winter-spring after adjusted for potential confounders. Accordingly, neonates with 25(OH)D <25 nmol/L had higher CRP concentrations (adjusted β = 2.39, 95% CI: 1.952, 2.837) and higher risk of CRP ≥10 mg/L (adjusted OR = 3.06, 95% CI: 2.00, 4.69), compared to neonates with 25(OH)D ≥25 nmol/L, when they were born in winter-spring (Figure 4).

Bottom Line: Stratified by 25(OH)D levels, per 10 nmol/L increase in 25(OH)D, CRP decreased by 1.42 mg/L (95% CI: 0.90, 1.95) among neonates with 25(OH)D <25.0 nmol/L, and decreased by 0.49 mg/L (95% CI: 0.17, 0.80) among neonates with 25(OH)D between 25.0 nmol/L and 49.9 nmol/L, after adjusting for potential confounders.Among neonates born in winter-spring, neonates with 25(OH)D <25 nmol/L had higher risk of CRP ≥10 mg/L (adjusted OR = 3.06, 95% CI: 2.00, 4.69), compared to neonates with 25(OH)D ≥25 nmol/L.Neonates with vitamin D deficiency had higher risk of exposure to elevated inflammation at birth.

View Article: PubMed Central - PubMed

Affiliation: Department of Gynecology and Obstetrics, Hefei First People's Hospital, Hefei 230001, China. taoruixue.good@163.com.

ABSTRACT
Some studies suggested that adequate vitamin D might reduce inflammation in adults. However, little is known about this association in early life. We aimed to determine the relationship between cord blood 25-hydroxyvitamin D (25(OH)D) and C-reactive protein (CRP) in neonates. Cord blood levels of 25(OH)D and CRP were measured in 1491 neonates in Hefei, China. Potential confounders including maternal sociodemographic characteristics, perinatal health status, lifestyle, and birth outcomes were prospectively collected. The average values of cord blood 25(OH)D and CRP were 39.43 nmol/L (SD = 20.35) and 6.71 mg/L (SD = 3.07), respectively. Stratified by 25(OH)D levels, per 10 nmol/L increase in 25(OH)D, CRP decreased by 1.42 mg/L (95% CI: 0.90, 1.95) among neonates with 25(OH)D <25.0 nmol/L, and decreased by 0.49 mg/L (95% CI: 0.17, 0.80) among neonates with 25(OH)D between 25.0 nmol/L and 49.9 nmol/L, after adjusting for potential confounders. However, no significant association between 25(OH)D and CRP was observed among neonates with 25(OH)D ≥50 nmol/L. Cord blood 25(OH)D and CRP levels showed a significant seasonal trend with lower 25(OH)D and higher CRP during winter-spring than summer-autumn. Stratified by season, a significant linear association of 25(OH)D with CRP was observed in neonates born in winter-spring (adjusted β = -0.11, 95% CI: -0.13, -0.10), but not summer-autumn. Among neonates born in winter-spring, neonates with 25(OH)D <25 nmol/L had higher risk of CRP ≥10 mg/L (adjusted OR = 3.06, 95% CI: 2.00, 4.69), compared to neonates with 25(OH)D ≥25 nmol/L. Neonates with vitamin D deficiency had higher risk of exposure to elevated inflammation at birth.

No MeSH data available.


Related in: MedlinePlus