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Inverse Correlation between Vitamin D and C-Reactive Protein in Newborns.

Tao RX, Zhou QF, Xu ZW, Hao JH, Huang K, Mou Z, Jiang XM, Tao FB, Zhu P - Nutrients (2015)

Bottom Line: Stratified by 25(OH)D levels, per 10 nmol/L increase in 25(OH)D, CRP decreased by 1.42 mg/L (95% CI: 0.90, 1.95) among neonates with 25(OH)D <25.0 nmol/L, and decreased by 0.49 mg/L (95% CI: 0.17, 0.80) among neonates with 25(OH)D between 25.0 nmol/L and 49.9 nmol/L, after adjusting for potential confounders.Among neonates born in winter-spring, neonates with 25(OH)D <25 nmol/L had higher risk of CRP ≥10 mg/L (adjusted OR = 3.06, 95% CI: 2.00, 4.69), compared to neonates with 25(OH)D ≥25 nmol/L.Neonates with vitamin D deficiency had higher risk of exposure to elevated inflammation at birth.

View Article: PubMed Central - PubMed

Affiliation: Department of Gynecology and Obstetrics, Hefei First People's Hospital, Hefei 230001, China. taoruixue.good@163.com.

ABSTRACT
Some studies suggested that adequate vitamin D might reduce inflammation in adults. However, little is known about this association in early life. We aimed to determine the relationship between cord blood 25-hydroxyvitamin D (25(OH)D) and C-reactive protein (CRP) in neonates. Cord blood levels of 25(OH)D and CRP were measured in 1491 neonates in Hefei, China. Potential confounders including maternal sociodemographic characteristics, perinatal health status, lifestyle, and birth outcomes were prospectively collected. The average values of cord blood 25(OH)D and CRP were 39.43 nmol/L (SD = 20.35) and 6.71 mg/L (SD = 3.07), respectively. Stratified by 25(OH)D levels, per 10 nmol/L increase in 25(OH)D, CRP decreased by 1.42 mg/L (95% CI: 0.90, 1.95) among neonates with 25(OH)D <25.0 nmol/L, and decreased by 0.49 mg/L (95% CI: 0.17, 0.80) among neonates with 25(OH)D between 25.0 nmol/L and 49.9 nmol/L, after adjusting for potential confounders. However, no significant association between 25(OH)D and CRP was observed among neonates with 25(OH)D ≥50 nmol/L. Cord blood 25(OH)D and CRP levels showed a significant seasonal trend with lower 25(OH)D and higher CRP during winter-spring than summer-autumn. Stratified by season, a significant linear association of 25(OH)D with CRP was observed in neonates born in winter-spring (adjusted β = -0.11, 95% CI: -0.13, -0.10), but not summer-autumn. Among neonates born in winter-spring, neonates with 25(OH)D <25 nmol/L had higher risk of CRP ≥10 mg/L (adjusted OR = 3.06, 95% CI: 2.00, 4.69), compared to neonates with 25(OH)D ≥25 nmol/L. Neonates with vitamin D deficiency had higher risk of exposure to elevated inflammation at birth.

No MeSH data available.


Related in: MedlinePlus

Seasonality of cord blood 25(OH)D and CRP (n = 1491). The trends of cord blood 25(OH)D and CRP levels across birth month were assessed by fitting the data to the best-fitting linear and sinusoidal model, respectively (A). The proportions of cord blood 25(OH)D <25.0 nmol/L (A) and CRP ≥ 10 mg/L (B) across birth month were assessed by linear regression model and nonlinear regression with sine function, respectively. Bars represent mean and 95% CI of the mean (A). The solid grey line denotes the fit of the regression model (A–C). The vertical lines denote the birth month of fitted minimum concentrations of CRP (A).
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nutrients-07-05468-f003: Seasonality of cord blood 25(OH)D and CRP (n = 1491). The trends of cord blood 25(OH)D and CRP levels across birth month were assessed by fitting the data to the best-fitting linear and sinusoidal model, respectively (A). The proportions of cord blood 25(OH)D <25.0 nmol/L (A) and CRP ≥ 10 mg/L (B) across birth month were assessed by linear regression model and nonlinear regression with sine function, respectively. Bars represent mean and 95% CI of the mean (A). The solid grey line denotes the fit of the regression model (A–C). The vertical lines denote the birth month of fitted minimum concentrations of CRP (A).

Mentions: Neonates born in winter-spring had significant lower means of 25(OH)D (27.59 ± 13.30 nmol/L vs. 49.89 ± 19.78 nmol/L, p < 0.001) and higher means of CRP (7.40 ± 3.21 mg/L vs. 6.19 ± 2.81 mg/L, p < 0.001), compared to neonates born in summer-autumn. To explore the seasonality of 25(OH)D and CRP levels, linear model (adjusted R-square = 0.96, p < 0.001) and nonlinear model using sine function (adjusted R-square = 0.97, p < 0.001) were performed to fit the 25(OH)D and CRP concentrations across birth month, respectively. Fitted maximum concentrations of CRP and minimum concentrations of 25(OH)D were simultaneously observed in neonates born in January. They also had maximum proportions of 25(OH)D <25 nmol/L and CRP ≥10 mg/L. Fitted maximum concentrations of 25(OH)D were observed in neonates born in September, however, fitted minimum concentrations of CRP and proportions of CRP ≥10 mg/L were observed in neonates born in June, rather than September (Figure 3). Additionally, Figure 3A suggested that there was a positive relation between 25(OH)D and CRP across birth month in neonates with 25(OH)D ≥42 nmol/L and born between July to September. However, multiple linear model showed no significant association after adjusting for potential confounders.


Inverse Correlation between Vitamin D and C-Reactive Protein in Newborns.

Tao RX, Zhou QF, Xu ZW, Hao JH, Huang K, Mou Z, Jiang XM, Tao FB, Zhu P - Nutrients (2015)

Seasonality of cord blood 25(OH)D and CRP (n = 1491). The trends of cord blood 25(OH)D and CRP levels across birth month were assessed by fitting the data to the best-fitting linear and sinusoidal model, respectively (A). The proportions of cord blood 25(OH)D <25.0 nmol/L (A) and CRP ≥ 10 mg/L (B) across birth month were assessed by linear regression model and nonlinear regression with sine function, respectively. Bars represent mean and 95% CI of the mean (A). The solid grey line denotes the fit of the regression model (A–C). The vertical lines denote the birth month of fitted minimum concentrations of CRP (A).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4663596&req=5

nutrients-07-05468-f003: Seasonality of cord blood 25(OH)D and CRP (n = 1491). The trends of cord blood 25(OH)D and CRP levels across birth month were assessed by fitting the data to the best-fitting linear and sinusoidal model, respectively (A). The proportions of cord blood 25(OH)D <25.0 nmol/L (A) and CRP ≥ 10 mg/L (B) across birth month were assessed by linear regression model and nonlinear regression with sine function, respectively. Bars represent mean and 95% CI of the mean (A). The solid grey line denotes the fit of the regression model (A–C). The vertical lines denote the birth month of fitted minimum concentrations of CRP (A).
Mentions: Neonates born in winter-spring had significant lower means of 25(OH)D (27.59 ± 13.30 nmol/L vs. 49.89 ± 19.78 nmol/L, p < 0.001) and higher means of CRP (7.40 ± 3.21 mg/L vs. 6.19 ± 2.81 mg/L, p < 0.001), compared to neonates born in summer-autumn. To explore the seasonality of 25(OH)D and CRP levels, linear model (adjusted R-square = 0.96, p < 0.001) and nonlinear model using sine function (adjusted R-square = 0.97, p < 0.001) were performed to fit the 25(OH)D and CRP concentrations across birth month, respectively. Fitted maximum concentrations of CRP and minimum concentrations of 25(OH)D were simultaneously observed in neonates born in January. They also had maximum proportions of 25(OH)D <25 nmol/L and CRP ≥10 mg/L. Fitted maximum concentrations of 25(OH)D were observed in neonates born in September, however, fitted minimum concentrations of CRP and proportions of CRP ≥10 mg/L were observed in neonates born in June, rather than September (Figure 3). Additionally, Figure 3A suggested that there was a positive relation between 25(OH)D and CRP across birth month in neonates with 25(OH)D ≥42 nmol/L and born between July to September. However, multiple linear model showed no significant association after adjusting for potential confounders.

Bottom Line: Stratified by 25(OH)D levels, per 10 nmol/L increase in 25(OH)D, CRP decreased by 1.42 mg/L (95% CI: 0.90, 1.95) among neonates with 25(OH)D <25.0 nmol/L, and decreased by 0.49 mg/L (95% CI: 0.17, 0.80) among neonates with 25(OH)D between 25.0 nmol/L and 49.9 nmol/L, after adjusting for potential confounders.Among neonates born in winter-spring, neonates with 25(OH)D <25 nmol/L had higher risk of CRP ≥10 mg/L (adjusted OR = 3.06, 95% CI: 2.00, 4.69), compared to neonates with 25(OH)D ≥25 nmol/L.Neonates with vitamin D deficiency had higher risk of exposure to elevated inflammation at birth.

View Article: PubMed Central - PubMed

Affiliation: Department of Gynecology and Obstetrics, Hefei First People's Hospital, Hefei 230001, China. taoruixue.good@163.com.

ABSTRACT
Some studies suggested that adequate vitamin D might reduce inflammation in adults. However, little is known about this association in early life. We aimed to determine the relationship between cord blood 25-hydroxyvitamin D (25(OH)D) and C-reactive protein (CRP) in neonates. Cord blood levels of 25(OH)D and CRP were measured in 1491 neonates in Hefei, China. Potential confounders including maternal sociodemographic characteristics, perinatal health status, lifestyle, and birth outcomes were prospectively collected. The average values of cord blood 25(OH)D and CRP were 39.43 nmol/L (SD = 20.35) and 6.71 mg/L (SD = 3.07), respectively. Stratified by 25(OH)D levels, per 10 nmol/L increase in 25(OH)D, CRP decreased by 1.42 mg/L (95% CI: 0.90, 1.95) among neonates with 25(OH)D <25.0 nmol/L, and decreased by 0.49 mg/L (95% CI: 0.17, 0.80) among neonates with 25(OH)D between 25.0 nmol/L and 49.9 nmol/L, after adjusting for potential confounders. However, no significant association between 25(OH)D and CRP was observed among neonates with 25(OH)D ≥50 nmol/L. Cord blood 25(OH)D and CRP levels showed a significant seasonal trend with lower 25(OH)D and higher CRP during winter-spring than summer-autumn. Stratified by season, a significant linear association of 25(OH)D with CRP was observed in neonates born in winter-spring (adjusted β = -0.11, 95% CI: -0.13, -0.10), but not summer-autumn. Among neonates born in winter-spring, neonates with 25(OH)D <25 nmol/L had higher risk of CRP ≥10 mg/L (adjusted OR = 3.06, 95% CI: 2.00, 4.69), compared to neonates with 25(OH)D ≥25 nmol/L. Neonates with vitamin D deficiency had higher risk of exposure to elevated inflammation at birth.

No MeSH data available.


Related in: MedlinePlus