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Inverse Correlation between Vitamin D and C-Reactive Protein in Newborns.

Tao RX, Zhou QF, Xu ZW, Hao JH, Huang K, Mou Z, Jiang XM, Tao FB, Zhu P - Nutrients (2015)

Bottom Line: Stratified by 25(OH)D levels, per 10 nmol/L increase in 25(OH)D, CRP decreased by 1.42 mg/L (95% CI: 0.90, 1.95) among neonates with 25(OH)D <25.0 nmol/L, and decreased by 0.49 mg/L (95% CI: 0.17, 0.80) among neonates with 25(OH)D between 25.0 nmol/L and 49.9 nmol/L, after adjusting for potential confounders.Among neonates born in winter-spring, neonates with 25(OH)D <25 nmol/L had higher risk of CRP ≥10 mg/L (adjusted OR = 3.06, 95% CI: 2.00, 4.69), compared to neonates with 25(OH)D ≥25 nmol/L.Neonates with vitamin D deficiency had higher risk of exposure to elevated inflammation at birth.

View Article: PubMed Central - PubMed

Affiliation: Department of Gynecology and Obstetrics, Hefei First People's Hospital, Hefei 230001, China. taoruixue.good@163.com.

ABSTRACT
Some studies suggested that adequate vitamin D might reduce inflammation in adults. However, little is known about this association in early life. We aimed to determine the relationship between cord blood 25-hydroxyvitamin D (25(OH)D) and C-reactive protein (CRP) in neonates. Cord blood levels of 25(OH)D and CRP were measured in 1491 neonates in Hefei, China. Potential confounders including maternal sociodemographic characteristics, perinatal health status, lifestyle, and birth outcomes were prospectively collected. The average values of cord blood 25(OH)D and CRP were 39.43 nmol/L (SD = 20.35) and 6.71 mg/L (SD = 3.07), respectively. Stratified by 25(OH)D levels, per 10 nmol/L increase in 25(OH)D, CRP decreased by 1.42 mg/L (95% CI: 0.90, 1.95) among neonates with 25(OH)D <25.0 nmol/L, and decreased by 0.49 mg/L (95% CI: 0.17, 0.80) among neonates with 25(OH)D between 25.0 nmol/L and 49.9 nmol/L, after adjusting for potential confounders. However, no significant association between 25(OH)D and CRP was observed among neonates with 25(OH)D ≥50 nmol/L. Cord blood 25(OH)D and CRP levels showed a significant seasonal trend with lower 25(OH)D and higher CRP during winter-spring than summer-autumn. Stratified by season, a significant linear association of 25(OH)D with CRP was observed in neonates born in winter-spring (adjusted β = -0.11, 95% CI: -0.13, -0.10), but not summer-autumn. Among neonates born in winter-spring, neonates with 25(OH)D <25 nmol/L had higher risk of CRP ≥10 mg/L (adjusted OR = 3.06, 95% CI: 2.00, 4.69), compared to neonates with 25(OH)D ≥25 nmol/L. Neonates with vitamin D deficiency had higher risk of exposure to elevated inflammation at birth.

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Association between cord blood 25(OH)D and CRP levels, stratified by 25(OH)D levels. Multiple linear models were conducted to assessed the adjusted regression coefficient among neonates with 25(OH)D less than 25.0 nmol/L (A, n = 389), between 25.0 nmol/L and 49.9 nmol/L (B, n = 731) and more than 50.0 nmol/L (C, n = 371), respectively. Potential confounders included maternal sociodemographic characteristics, perinatal health status, lifestyle, and birth outcomes. A nonlinear regression model with sine function was conducted to fit the nonlinear relation between 25(OH)D and CRP among all neonates (D, n = 1491). The solid black line denotes the fit of the regression model, the solid grey line denote 95% CI. The vertical lines denote 25(OH)D benchmarks.
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nutrients-07-05468-f002: Association between cord blood 25(OH)D and CRP levels, stratified by 25(OH)D levels. Multiple linear models were conducted to assessed the adjusted regression coefficient among neonates with 25(OH)D less than 25.0 nmol/L (A, n = 389), between 25.0 nmol/L and 49.9 nmol/L (B, n = 731) and more than 50.0 nmol/L (C, n = 371), respectively. Potential confounders included maternal sociodemographic characteristics, perinatal health status, lifestyle, and birth outcomes. A nonlinear regression model with sine function was conducted to fit the nonlinear relation between 25(OH)D and CRP among all neonates (D, n = 1491). The solid black line denotes the fit of the regression model, the solid grey line denote 95% CI. The vertical lines denote 25(OH)D benchmarks.

Mentions: Stratified by 25(OH)D concentrations, per 10 nmol/L increase in 25(OH)D levels, CRP decreased by 1.42 mg/L (95% CI: 0.90, 1.95) in neonates with 25(OH)D <25.0 nmol/L (Figure 2A) and decreased by 0.49 mg/L (95% CI: 0.17, 0.80) in neonates with 25(OH)D between 25.0 nmol/L and 49.9 nmol/L (Figure 2B), after adjusting for potential confounders. However, no significant association between 25(OH)D and CRP was observed in neonates with 25(OH)D ≥50 nmol/L (Figure 2C). A non-linear trend in CRP levels across 25(OH)D concentrations was observed. We further fitted the non-linear regression model using a sine function to best display the association. The solid black line shows the best fit analysis for the association of 25(OH)D with the CRP (adjusted R-square = 0.14, p < 0.001) (Figure 2D). The model fitted the data well as the residuals were randomly distributed.


Inverse Correlation between Vitamin D and C-Reactive Protein in Newborns.

Tao RX, Zhou QF, Xu ZW, Hao JH, Huang K, Mou Z, Jiang XM, Tao FB, Zhu P - Nutrients (2015)

Association between cord blood 25(OH)D and CRP levels, stratified by 25(OH)D levels. Multiple linear models were conducted to assessed the adjusted regression coefficient among neonates with 25(OH)D less than 25.0 nmol/L (A, n = 389), between 25.0 nmol/L and 49.9 nmol/L (B, n = 731) and more than 50.0 nmol/L (C, n = 371), respectively. Potential confounders included maternal sociodemographic characteristics, perinatal health status, lifestyle, and birth outcomes. A nonlinear regression model with sine function was conducted to fit the nonlinear relation between 25(OH)D and CRP among all neonates (D, n = 1491). The solid black line denotes the fit of the regression model, the solid grey line denote 95% CI. The vertical lines denote 25(OH)D benchmarks.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4663596&req=5

nutrients-07-05468-f002: Association between cord blood 25(OH)D and CRP levels, stratified by 25(OH)D levels. Multiple linear models were conducted to assessed the adjusted regression coefficient among neonates with 25(OH)D less than 25.0 nmol/L (A, n = 389), between 25.0 nmol/L and 49.9 nmol/L (B, n = 731) and more than 50.0 nmol/L (C, n = 371), respectively. Potential confounders included maternal sociodemographic characteristics, perinatal health status, lifestyle, and birth outcomes. A nonlinear regression model with sine function was conducted to fit the nonlinear relation between 25(OH)D and CRP among all neonates (D, n = 1491). The solid black line denotes the fit of the regression model, the solid grey line denote 95% CI. The vertical lines denote 25(OH)D benchmarks.
Mentions: Stratified by 25(OH)D concentrations, per 10 nmol/L increase in 25(OH)D levels, CRP decreased by 1.42 mg/L (95% CI: 0.90, 1.95) in neonates with 25(OH)D <25.0 nmol/L (Figure 2A) and decreased by 0.49 mg/L (95% CI: 0.17, 0.80) in neonates with 25(OH)D between 25.0 nmol/L and 49.9 nmol/L (Figure 2B), after adjusting for potential confounders. However, no significant association between 25(OH)D and CRP was observed in neonates with 25(OH)D ≥50 nmol/L (Figure 2C). A non-linear trend in CRP levels across 25(OH)D concentrations was observed. We further fitted the non-linear regression model using a sine function to best display the association. The solid black line shows the best fit analysis for the association of 25(OH)D with the CRP (adjusted R-square = 0.14, p < 0.001) (Figure 2D). The model fitted the data well as the residuals were randomly distributed.

Bottom Line: Stratified by 25(OH)D levels, per 10 nmol/L increase in 25(OH)D, CRP decreased by 1.42 mg/L (95% CI: 0.90, 1.95) among neonates with 25(OH)D <25.0 nmol/L, and decreased by 0.49 mg/L (95% CI: 0.17, 0.80) among neonates with 25(OH)D between 25.0 nmol/L and 49.9 nmol/L, after adjusting for potential confounders.Among neonates born in winter-spring, neonates with 25(OH)D <25 nmol/L had higher risk of CRP ≥10 mg/L (adjusted OR = 3.06, 95% CI: 2.00, 4.69), compared to neonates with 25(OH)D ≥25 nmol/L.Neonates with vitamin D deficiency had higher risk of exposure to elevated inflammation at birth.

View Article: PubMed Central - PubMed

Affiliation: Department of Gynecology and Obstetrics, Hefei First People's Hospital, Hefei 230001, China. taoruixue.good@163.com.

ABSTRACT
Some studies suggested that adequate vitamin D might reduce inflammation in adults. However, little is known about this association in early life. We aimed to determine the relationship between cord blood 25-hydroxyvitamin D (25(OH)D) and C-reactive protein (CRP) in neonates. Cord blood levels of 25(OH)D and CRP were measured in 1491 neonates in Hefei, China. Potential confounders including maternal sociodemographic characteristics, perinatal health status, lifestyle, and birth outcomes were prospectively collected. The average values of cord blood 25(OH)D and CRP were 39.43 nmol/L (SD = 20.35) and 6.71 mg/L (SD = 3.07), respectively. Stratified by 25(OH)D levels, per 10 nmol/L increase in 25(OH)D, CRP decreased by 1.42 mg/L (95% CI: 0.90, 1.95) among neonates with 25(OH)D <25.0 nmol/L, and decreased by 0.49 mg/L (95% CI: 0.17, 0.80) among neonates with 25(OH)D between 25.0 nmol/L and 49.9 nmol/L, after adjusting for potential confounders. However, no significant association between 25(OH)D and CRP was observed among neonates with 25(OH)D ≥50 nmol/L. Cord blood 25(OH)D and CRP levels showed a significant seasonal trend with lower 25(OH)D and higher CRP during winter-spring than summer-autumn. Stratified by season, a significant linear association of 25(OH)D with CRP was observed in neonates born in winter-spring (adjusted β = -0.11, 95% CI: -0.13, -0.10), but not summer-autumn. Among neonates born in winter-spring, neonates with 25(OH)D <25 nmol/L had higher risk of CRP ≥10 mg/L (adjusted OR = 3.06, 95% CI: 2.00, 4.69), compared to neonates with 25(OH)D ≥25 nmol/L. Neonates with vitamin D deficiency had higher risk of exposure to elevated inflammation at birth.

No MeSH data available.


Related in: MedlinePlus