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Inverse Correlation between Vitamin D and C-Reactive Protein in Newborns.

Tao RX, Zhou QF, Xu ZW, Hao JH, Huang K, Mou Z, Jiang XM, Tao FB, Zhu P - Nutrients (2015)

Bottom Line: Stratified by 25(OH)D levels, per 10 nmol/L increase in 25(OH)D, CRP decreased by 1.42 mg/L (95% CI: 0.90, 1.95) among neonates with 25(OH)D <25.0 nmol/L, and decreased by 0.49 mg/L (95% CI: 0.17, 0.80) among neonates with 25(OH)D between 25.0 nmol/L and 49.9 nmol/L, after adjusting for potential confounders.Among neonates born in winter-spring, neonates with 25(OH)D <25 nmol/L had higher risk of CRP ≥10 mg/L (adjusted OR = 3.06, 95% CI: 2.00, 4.69), compared to neonates with 25(OH)D ≥25 nmol/L.Neonates with vitamin D deficiency had higher risk of exposure to elevated inflammation at birth.

View Article: PubMed Central - PubMed

Affiliation: Department of Gynecology and Obstetrics, Hefei First People's Hospital, Hefei 230001, China. taoruixue.good@163.com.

ABSTRACT
Some studies suggested that adequate vitamin D might reduce inflammation in adults. However, little is known about this association in early life. We aimed to determine the relationship between cord blood 25-hydroxyvitamin D (25(OH)D) and C-reactive protein (CRP) in neonates. Cord blood levels of 25(OH)D and CRP were measured in 1491 neonates in Hefei, China. Potential confounders including maternal sociodemographic characteristics, perinatal health status, lifestyle, and birth outcomes were prospectively collected. The average values of cord blood 25(OH)D and CRP were 39.43 nmol/L (SD = 20.35) and 6.71 mg/L (SD = 3.07), respectively. Stratified by 25(OH)D levels, per 10 nmol/L increase in 25(OH)D, CRP decreased by 1.42 mg/L (95% CI: 0.90, 1.95) among neonates with 25(OH)D <25.0 nmol/L, and decreased by 0.49 mg/L (95% CI: 0.17, 0.80) among neonates with 25(OH)D between 25.0 nmol/L and 49.9 nmol/L, after adjusting for potential confounders. However, no significant association between 25(OH)D and CRP was observed among neonates with 25(OH)D ≥50 nmol/L. Cord blood 25(OH)D and CRP levels showed a significant seasonal trend with lower 25(OH)D and higher CRP during winter-spring than summer-autumn. Stratified by season, a significant linear association of 25(OH)D with CRP was observed in neonates born in winter-spring (adjusted β = -0.11, 95% CI: -0.13, -0.10), but not summer-autumn. Among neonates born in winter-spring, neonates with 25(OH)D <25 nmol/L had higher risk of CRP ≥10 mg/L (adjusted OR = 3.06, 95% CI: 2.00, 4.69), compared to neonates with 25(OH)D ≥25 nmol/L. Neonates with vitamin D deficiency had higher risk of exposure to elevated inflammation at birth.

No MeSH data available.


Related in: MedlinePlus

Means of cord blood CRP levels (A) and proportions of CRP ≥10 mg/L (B) across deciles of 25(OH)D levels in neonates (n = 1491). Bars represent mean ± SD (A). D1, D2 and D3 mean the first, second and third decile respectively, and so on. ∗ Represents the significant difference with p < 0.05, compared to the tenth decile of 25(OH)D levels.
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nutrients-07-05468-f001: Means of cord blood CRP levels (A) and proportions of CRP ≥10 mg/L (B) across deciles of 25(OH)D levels in neonates (n = 1491). Bars represent mean ± SD (A). D1, D2 and D3 mean the first, second and third decile respectively, and so on. ∗ Represents the significant difference with p < 0.05, compared to the tenth decile of 25(OH)D levels.

Mentions: The means of CRP levels (p-trend < 0.001) and proportions of CRP ≥10 mg/L (p-trend < 0.001) significantly decreased across deciles of 25(OH)D concentrations. Compared to neonates in the 10th decile of 25(OH)D concentrations, neonates in the first (adjusted β = 3.71, 95% CI: 3.10, 4.32; adjusted OR = 9.49, 95% CI: 3.56, 25.32), second (adjusted β = 2.52, 95% CI: 1.91, 3.14; adjusted OR = 5.26, 95% CI: 1.96, 14.08), third (adjusted β = 1.42, 95% CI: 0.75, 2.09; adjusted OR = 2.82, 95% CI: 1.03, 7.73), fourth (adjusted β = 1.01, 95% CI: 0.35, 1.69; adjusted OR = 2.96, 95% CI: 1.09, 8.01) and fifth (adjusted β = 0.99, 95% CI: 0.29, 1.69; adjusted OR = 3.21, 95% CI: 1.20, 8.59) deciles of 25(OH)D had higher CRP concentrations (Figure 1A) and higher risk of CRP ≥10 mg/L (Figure 1B).


Inverse Correlation between Vitamin D and C-Reactive Protein in Newborns.

Tao RX, Zhou QF, Xu ZW, Hao JH, Huang K, Mou Z, Jiang XM, Tao FB, Zhu P - Nutrients (2015)

Means of cord blood CRP levels (A) and proportions of CRP ≥10 mg/L (B) across deciles of 25(OH)D levels in neonates (n = 1491). Bars represent mean ± SD (A). D1, D2 and D3 mean the first, second and third decile respectively, and so on. ∗ Represents the significant difference with p < 0.05, compared to the tenth decile of 25(OH)D levels.
© Copyright Policy
Related In: Results  -  Collection

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Show All Figures
getmorefigures.php?uid=PMC4663596&req=5

nutrients-07-05468-f001: Means of cord blood CRP levels (A) and proportions of CRP ≥10 mg/L (B) across deciles of 25(OH)D levels in neonates (n = 1491). Bars represent mean ± SD (A). D1, D2 and D3 mean the first, second and third decile respectively, and so on. ∗ Represents the significant difference with p < 0.05, compared to the tenth decile of 25(OH)D levels.
Mentions: The means of CRP levels (p-trend < 0.001) and proportions of CRP ≥10 mg/L (p-trend < 0.001) significantly decreased across deciles of 25(OH)D concentrations. Compared to neonates in the 10th decile of 25(OH)D concentrations, neonates in the first (adjusted β = 3.71, 95% CI: 3.10, 4.32; adjusted OR = 9.49, 95% CI: 3.56, 25.32), second (adjusted β = 2.52, 95% CI: 1.91, 3.14; adjusted OR = 5.26, 95% CI: 1.96, 14.08), third (adjusted β = 1.42, 95% CI: 0.75, 2.09; adjusted OR = 2.82, 95% CI: 1.03, 7.73), fourth (adjusted β = 1.01, 95% CI: 0.35, 1.69; adjusted OR = 2.96, 95% CI: 1.09, 8.01) and fifth (adjusted β = 0.99, 95% CI: 0.29, 1.69; adjusted OR = 3.21, 95% CI: 1.20, 8.59) deciles of 25(OH)D had higher CRP concentrations (Figure 1A) and higher risk of CRP ≥10 mg/L (Figure 1B).

Bottom Line: Stratified by 25(OH)D levels, per 10 nmol/L increase in 25(OH)D, CRP decreased by 1.42 mg/L (95% CI: 0.90, 1.95) among neonates with 25(OH)D <25.0 nmol/L, and decreased by 0.49 mg/L (95% CI: 0.17, 0.80) among neonates with 25(OH)D between 25.0 nmol/L and 49.9 nmol/L, after adjusting for potential confounders.Among neonates born in winter-spring, neonates with 25(OH)D <25 nmol/L had higher risk of CRP ≥10 mg/L (adjusted OR = 3.06, 95% CI: 2.00, 4.69), compared to neonates with 25(OH)D ≥25 nmol/L.Neonates with vitamin D deficiency had higher risk of exposure to elevated inflammation at birth.

View Article: PubMed Central - PubMed

Affiliation: Department of Gynecology and Obstetrics, Hefei First People's Hospital, Hefei 230001, China. taoruixue.good@163.com.

ABSTRACT
Some studies suggested that adequate vitamin D might reduce inflammation in adults. However, little is known about this association in early life. We aimed to determine the relationship between cord blood 25-hydroxyvitamin D (25(OH)D) and C-reactive protein (CRP) in neonates. Cord blood levels of 25(OH)D and CRP were measured in 1491 neonates in Hefei, China. Potential confounders including maternal sociodemographic characteristics, perinatal health status, lifestyle, and birth outcomes were prospectively collected. The average values of cord blood 25(OH)D and CRP were 39.43 nmol/L (SD = 20.35) and 6.71 mg/L (SD = 3.07), respectively. Stratified by 25(OH)D levels, per 10 nmol/L increase in 25(OH)D, CRP decreased by 1.42 mg/L (95% CI: 0.90, 1.95) among neonates with 25(OH)D <25.0 nmol/L, and decreased by 0.49 mg/L (95% CI: 0.17, 0.80) among neonates with 25(OH)D between 25.0 nmol/L and 49.9 nmol/L, after adjusting for potential confounders. However, no significant association between 25(OH)D and CRP was observed among neonates with 25(OH)D ≥50 nmol/L. Cord blood 25(OH)D and CRP levels showed a significant seasonal trend with lower 25(OH)D and higher CRP during winter-spring than summer-autumn. Stratified by season, a significant linear association of 25(OH)D with CRP was observed in neonates born in winter-spring (adjusted β = -0.11, 95% CI: -0.13, -0.10), but not summer-autumn. Among neonates born in winter-spring, neonates with 25(OH)D <25 nmol/L had higher risk of CRP ≥10 mg/L (adjusted OR = 3.06, 95% CI: 2.00, 4.69), compared to neonates with 25(OH)D ≥25 nmol/L. Neonates with vitamin D deficiency had higher risk of exposure to elevated inflammation at birth.

No MeSH data available.


Related in: MedlinePlus