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Association of Dietary Vitamin A and β-Carotene Intake with the Risk of Lung Cancer: A Meta-Analysis of 19 Publications.

Yu N, Su X, Wang Z, Dai B, Kang J - Nutrients (2015)

Bottom Line: We used the random-effect model to estimate the relative risk (RR) and their 95% CI.Small-study effect was assessed using Egger's test.In conclusions, higher category of dietary β-carotene and vitamin A intakes could reduce the risk of lung cancer.

View Article: PubMed Central - PubMed

Affiliation: Department of Respiratory Medicine, The First Hospital of China Medical University, No.155 Nanjing North Street, He-ping District, Shenyang 110001, Liaoning, China. nayu888@yeah.net.

ABSTRACT
Whether dietary β-carotene and vitamin A intake protect against lung cancer risk is not clear. Therefore, we performed this meta-analysis to investigate the association between them. The related articles were searched using the databases PubMed and the Web of Knowledge up to May 2015. We used the random-effect model to estimate the relative risk (RR) and their 95% CI. Small-study effect was assessed using Egger's test. In total, 19 studies comprising 10,261 lung cancer cases met the inclusion criteria. The pooled RR and their 95% CI was 0.855 (0.739-0.989) for higher category of dietary vitamin A intake and lung cancer risk, especially among Asian populations and in the cohort studies. Evidence from 18 studies suggested that higher category of dietary β-carotene intake could reduce lung cancer risk (0.768 (0.675-0.874)).The associations were also significant in American and Asian populations. In conclusions, higher category of dietary β-carotene and vitamin A intakes could reduce the risk of lung cancer. However, the dose-response analysis was not performed due to the limited data in each individual study. Due to this limitation, further studies with detailed dose, cases and person-years for β-carotene and vitamin A of each category are wanted to assess this dose-response association.

No MeSH data available.


Related in: MedlinePlus

The multivariate-adjusted risk of lung cancer for the highest versus lowest categories of β-carotene intake.
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nutrients-07-05463-f003: The multivariate-adjusted risk of lung cancer for the highest versus lowest categories of β-carotene intake.

Mentions: Seventeen articles [10,11,12,13,20,22,23,24,25,26,27,28,29,30,31,32,33] with 18 studies involving 9372 lung cancer cases reported the association between dietary β-carotene intake and lung cancer risk. Six of these included studies found a positive relationship between dietary β-carotene intake and lung cancer risk, while 12 studies found a negative result. Pooled results indicated that highest category of β-carotene intake could reduce the lung cancer risk (summary RR = 0.768, 95% CI = 0.675–0.874, I2 = 55.9%) (Figure 3).


Association of Dietary Vitamin A and β-Carotene Intake with the Risk of Lung Cancer: A Meta-Analysis of 19 Publications.

Yu N, Su X, Wang Z, Dai B, Kang J - Nutrients (2015)

The multivariate-adjusted risk of lung cancer for the highest versus lowest categories of β-carotene intake.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4663591&req=5

nutrients-07-05463-f003: The multivariate-adjusted risk of lung cancer for the highest versus lowest categories of β-carotene intake.
Mentions: Seventeen articles [10,11,12,13,20,22,23,24,25,26,27,28,29,30,31,32,33] with 18 studies involving 9372 lung cancer cases reported the association between dietary β-carotene intake and lung cancer risk. Six of these included studies found a positive relationship between dietary β-carotene intake and lung cancer risk, while 12 studies found a negative result. Pooled results indicated that highest category of β-carotene intake could reduce the lung cancer risk (summary RR = 0.768, 95% CI = 0.675–0.874, I2 = 55.9%) (Figure 3).

Bottom Line: We used the random-effect model to estimate the relative risk (RR) and their 95% CI.Small-study effect was assessed using Egger's test.In conclusions, higher category of dietary β-carotene and vitamin A intakes could reduce the risk of lung cancer.

View Article: PubMed Central - PubMed

Affiliation: Department of Respiratory Medicine, The First Hospital of China Medical University, No.155 Nanjing North Street, He-ping District, Shenyang 110001, Liaoning, China. nayu888@yeah.net.

ABSTRACT
Whether dietary β-carotene and vitamin A intake protect against lung cancer risk is not clear. Therefore, we performed this meta-analysis to investigate the association between them. The related articles were searched using the databases PubMed and the Web of Knowledge up to May 2015. We used the random-effect model to estimate the relative risk (RR) and their 95% CI. Small-study effect was assessed using Egger's test. In total, 19 studies comprising 10,261 lung cancer cases met the inclusion criteria. The pooled RR and their 95% CI was 0.855 (0.739-0.989) for higher category of dietary vitamin A intake and lung cancer risk, especially among Asian populations and in the cohort studies. Evidence from 18 studies suggested that higher category of dietary β-carotene intake could reduce lung cancer risk (0.768 (0.675-0.874)).The associations were also significant in American and Asian populations. In conclusions, higher category of dietary β-carotene and vitamin A intakes could reduce the risk of lung cancer. However, the dose-response analysis was not performed due to the limited data in each individual study. Due to this limitation, further studies with detailed dose, cases and person-years for β-carotene and vitamin A of each category are wanted to assess this dose-response association.

No MeSH data available.


Related in: MedlinePlus