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Association of Dietary Vitamin A and β-Carotene Intake with the Risk of Lung Cancer: A Meta-Analysis of 19 Publications.

Yu N, Su X, Wang Z, Dai B, Kang J - Nutrients (2015)

Bottom Line: We used the random-effect model to estimate the relative risk (RR) and their 95% CI.Small-study effect was assessed using Egger's test.In conclusions, higher category of dietary β-carotene and vitamin A intakes could reduce the risk of lung cancer.

View Article: PubMed Central - PubMed

Affiliation: Department of Respiratory Medicine, The First Hospital of China Medical University, No.155 Nanjing North Street, He-ping District, Shenyang 110001, Liaoning, China. nayu888@yeah.net.

ABSTRACT
Whether dietary β-carotene and vitamin A intake protect against lung cancer risk is not clear. Therefore, we performed this meta-analysis to investigate the association between them. The related articles were searched using the databases PubMed and the Web of Knowledge up to May 2015. We used the random-effect model to estimate the relative risk (RR) and their 95% CI. Small-study effect was assessed using Egger's test. In total, 19 studies comprising 10,261 lung cancer cases met the inclusion criteria. The pooled RR and their 95% CI was 0.855 (0.739-0.989) for higher category of dietary vitamin A intake and lung cancer risk, especially among Asian populations and in the cohort studies. Evidence from 18 studies suggested that higher category of dietary β-carotene intake could reduce lung cancer risk (0.768 (0.675-0.874)).The associations were also significant in American and Asian populations. In conclusions, higher category of dietary β-carotene and vitamin A intakes could reduce the risk of lung cancer. However, the dose-response analysis was not performed due to the limited data in each individual study. Due to this limitation, further studies with detailed dose, cases and person-years for β-carotene and vitamin A of each category are wanted to assess this dose-response association.

No MeSH data available.


Related in: MedlinePlus

The flow diagram of screened, excluded, and analyzed publications.
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nutrients-07-05463-f001: The flow diagram of screened, excluded, and analyzed publications.

Mentions: Figure 1 showed the detailed steps of the literature search. We identified 2819 relevant articles from our databases, and 48 articles left after reviewing the title/abstract. Four review articles, five articles reporting the animal studies, two duplicated articles, 16 articles lacking the RR or 95% CI, and two letter to the editor articles were further excluded after full-text review. Hence, 19 articles [10,11,12,13,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33] involving 10,261 lung cancer cases were included. Ten studies were conducted from United States, two from the Netherlands, three from China, two from Canada, one from Finland and one from Uruguay. Table 1 showed the detailed characteristics of the included studies.


Association of Dietary Vitamin A and β-Carotene Intake with the Risk of Lung Cancer: A Meta-Analysis of 19 Publications.

Yu N, Su X, Wang Z, Dai B, Kang J - Nutrients (2015)

The flow diagram of screened, excluded, and analyzed publications.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4663591&req=5

nutrients-07-05463-f001: The flow diagram of screened, excluded, and analyzed publications.
Mentions: Figure 1 showed the detailed steps of the literature search. We identified 2819 relevant articles from our databases, and 48 articles left after reviewing the title/abstract. Four review articles, five articles reporting the animal studies, two duplicated articles, 16 articles lacking the RR or 95% CI, and two letter to the editor articles were further excluded after full-text review. Hence, 19 articles [10,11,12,13,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33] involving 10,261 lung cancer cases were included. Ten studies were conducted from United States, two from the Netherlands, three from China, two from Canada, one from Finland and one from Uruguay. Table 1 showed the detailed characteristics of the included studies.

Bottom Line: We used the random-effect model to estimate the relative risk (RR) and their 95% CI.Small-study effect was assessed using Egger's test.In conclusions, higher category of dietary β-carotene and vitamin A intakes could reduce the risk of lung cancer.

View Article: PubMed Central - PubMed

Affiliation: Department of Respiratory Medicine, The First Hospital of China Medical University, No.155 Nanjing North Street, He-ping District, Shenyang 110001, Liaoning, China. nayu888@yeah.net.

ABSTRACT
Whether dietary β-carotene and vitamin A intake protect against lung cancer risk is not clear. Therefore, we performed this meta-analysis to investigate the association between them. The related articles were searched using the databases PubMed and the Web of Knowledge up to May 2015. We used the random-effect model to estimate the relative risk (RR) and their 95% CI. Small-study effect was assessed using Egger's test. In total, 19 studies comprising 10,261 lung cancer cases met the inclusion criteria. The pooled RR and their 95% CI was 0.855 (0.739-0.989) for higher category of dietary vitamin A intake and lung cancer risk, especially among Asian populations and in the cohort studies. Evidence from 18 studies suggested that higher category of dietary β-carotene intake could reduce lung cancer risk (0.768 (0.675-0.874)).The associations were also significant in American and Asian populations. In conclusions, higher category of dietary β-carotene and vitamin A intakes could reduce the risk of lung cancer. However, the dose-response analysis was not performed due to the limited data in each individual study. Due to this limitation, further studies with detailed dose, cases and person-years for β-carotene and vitamin A of each category are wanted to assess this dose-response association.

No MeSH data available.


Related in: MedlinePlus