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Cell Systems to Investigate the Impact of Polyphenols on Cardiovascular Health.

Grootaert C, Kamiloglu S, Capanoglu E, Van Camp J - Nutrients (2015)

Bottom Line: Polyphenols are a diverse group of micronutrients from plant origin that may serve as antioxidants and that contribute to human health in general.We will also review the current trends in cell culture research, including co-culture methodologies.Finally, we will discuss the potential of these advanced models to screen for cardiovascular effects of the large pool of bioactive polyphenols present in foods and their metabolites.

View Article: PubMed Central - PubMed

Affiliation: Laboratory of Food Chemistry and Human Nutrition, Department of Food Safety and Food Quality, Faculty of Bioscience Engineering, Ghent University, Coupure Links, Ghent 653 B-9000, Belgium. charlotte.grootaert@ugent.be.

ABSTRACT
Polyphenols are a diverse group of micronutrients from plant origin that may serve as antioxidants and that contribute to human health in general. More specifically, many research groups have investigated their protective effect against cardiovascular diseases in several animal studies and human trials. Yet, because of the excessive processing of the polyphenol structure by human cells and the residing intestinal microbial community, which results in a large variability between the test subjects, the exact mechanisms of their protective effects are still under investigation. To this end, simplified cell culture systems have been used to decrease the inter-individual variability in mechanistic studies. In this review, we will discuss the different cell culture models that have been used so far for polyphenol research in the context of cardiovascular diseases. We will also review the current trends in cell culture research, including co-culture methodologies. Finally, we will discuss the potential of these advanced models to screen for cardiovascular effects of the large pool of bioactive polyphenols present in foods and their metabolites.

No MeSH data available.


Related in: MedlinePlus

Classification of major classes of dietary biophenols.
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nutrients-07-05462-f001: Classification of major classes of dietary biophenols.

Mentions: Polyphenols are divided into several classes according to the number of phenol rings that they contain and to the structural elements that bind these rings to each other. The main groups of polyphenols are flavonoids, phenolic acids, stilbenes, and lignans [1,2] (Figure 1).


Cell Systems to Investigate the Impact of Polyphenols on Cardiovascular Health.

Grootaert C, Kamiloglu S, Capanoglu E, Van Camp J - Nutrients (2015)

Classification of major classes of dietary biophenols.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4663590&req=5

nutrients-07-05462-f001: Classification of major classes of dietary biophenols.
Mentions: Polyphenols are divided into several classes according to the number of phenol rings that they contain and to the structural elements that bind these rings to each other. The main groups of polyphenols are flavonoids, phenolic acids, stilbenes, and lignans [1,2] (Figure 1).

Bottom Line: Polyphenols are a diverse group of micronutrients from plant origin that may serve as antioxidants and that contribute to human health in general.We will also review the current trends in cell culture research, including co-culture methodologies.Finally, we will discuss the potential of these advanced models to screen for cardiovascular effects of the large pool of bioactive polyphenols present in foods and their metabolites.

View Article: PubMed Central - PubMed

Affiliation: Laboratory of Food Chemistry and Human Nutrition, Department of Food Safety and Food Quality, Faculty of Bioscience Engineering, Ghent University, Coupure Links, Ghent 653 B-9000, Belgium. charlotte.grootaert@ugent.be.

ABSTRACT
Polyphenols are a diverse group of micronutrients from plant origin that may serve as antioxidants and that contribute to human health in general. More specifically, many research groups have investigated their protective effect against cardiovascular diseases in several animal studies and human trials. Yet, because of the excessive processing of the polyphenol structure by human cells and the residing intestinal microbial community, which results in a large variability between the test subjects, the exact mechanisms of their protective effects are still under investigation. To this end, simplified cell culture systems have been used to decrease the inter-individual variability in mechanistic studies. In this review, we will discuss the different cell culture models that have been used so far for polyphenol research in the context of cardiovascular diseases. We will also review the current trends in cell culture research, including co-culture methodologies. Finally, we will discuss the potential of these advanced models to screen for cardiovascular effects of the large pool of bioactive polyphenols present in foods and their metabolites.

No MeSH data available.


Related in: MedlinePlus