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Better Adherence to the Mediterranean Diet Could Mitigate the Adverse Consequences of Obesity on Cardiovascular Disease: The SUN Prospective Cohort.

Eguaras S, Toledo E, Hernández-Hernández A, Cervantes S, Martínez-González MA - Nutrients (2015)

Bottom Line: An increased risk of CVD across categories of body mass index (BMI) was apparent if adherence to the MedDiet was low, with multivariable-adjusted hazard ratios (HRs): 1.44 (95% confidence interval: 0.93-2.25) for ≥25 - <30 kg/m² of BMI and 2.00 (1.04-3.83) for ≥30 kg/m² of BMI, compared to a BMI < 25 kg/m².Better adherence to the MedDiet was associated with reduced CVD events (p for trend = 0.029).Our results suggest that the MedDiet could mitigate the harmful cardiovascular effect of overweight/obesity.

View Article: PubMed Central - PubMed

Affiliation: Servicio Navarro de Salud-Osasunbidea-IdiSNA, Navarra Institute for Health Research, 31002 Pamplona, Spain. seguaras@alumni.unav.es.

ABSTRACT
Strong observational evidence supports the association between obesity and cardiovascular events. In elderly high-risk subjects, the Mediterranean diet (MedDiet) was reported to counteract the adverse cardiovascular effects of adiposity. Whether this same attenuation is also present in younger subjects is not known. We prospectively examined the association between obesity and cardiovascular clinical events (myocardial infarction, stroke or cardiovascular death) after 10.9 years follow-up in 19,065 middle-aged men and women (average age 38 year) according to their adherence to the MedDiet (<6 points or ≥6 points in the Trichopoulou's Mediterranean Diet Score). We observed 152 incident cases of cardiovascular disease (CVD). An increased risk of CVD across categories of body mass index (BMI) was apparent if adherence to the MedDiet was low, with multivariable-adjusted hazard ratios (HRs): 1.44 (95% confidence interval: 0.93-2.25) for ≥25 - <30 kg/m² of BMI and 2.00 (1.04-3.83) for ≥30 kg/m² of BMI, compared to a BMI < 25 kg/m². In contrast, these estimates were 0.77 (0.35-1.67) and 1.15 (0.39-3.43) with good adherence to MedDiet. Better adherence to the MedDiet was associated with reduced CVD events (p for trend = 0.029). Our results suggest that the MedDiet could mitigate the harmful cardiovascular effect of overweight/obesity.

No MeSH data available.


Related in: MedlinePlus

Relative risk of cardiovascular disease (HR and 95% confidence intervals) in the SUN project according to baseline body mass index and adherence to MedDiet.
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nutrients-07-05457-f002: Relative risk of cardiovascular disease (HR and 95% confidence intervals) in the SUN project according to baseline body mass index and adherence to MedDiet.

Mentions: Figure 2 presents multivariable-adjusted hazard ratios for the joint classification according to both values of BMI (3 groups with the following 2 cut-off points: 25 and 30 kg/m2) and adherence to MedDiet (two categories: low adherence (<6 points) and high adherence (≥6 points)). The reference category was the group with low BMI (<25) and high adherence to MedDiet (score ≥6). In the group with better adherence to MedDiet, the risk of CVD was lower than in the poor adherence group across all BMI categories.


Better Adherence to the Mediterranean Diet Could Mitigate the Adverse Consequences of Obesity on Cardiovascular Disease: The SUN Prospective Cohort.

Eguaras S, Toledo E, Hernández-Hernández A, Cervantes S, Martínez-González MA - Nutrients (2015)

Relative risk of cardiovascular disease (HR and 95% confidence intervals) in the SUN project according to baseline body mass index and adherence to MedDiet.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4663585&req=5

nutrients-07-05457-f002: Relative risk of cardiovascular disease (HR and 95% confidence intervals) in the SUN project according to baseline body mass index and adherence to MedDiet.
Mentions: Figure 2 presents multivariable-adjusted hazard ratios for the joint classification according to both values of BMI (3 groups with the following 2 cut-off points: 25 and 30 kg/m2) and adherence to MedDiet (two categories: low adherence (<6 points) and high adherence (≥6 points)). The reference category was the group with low BMI (<25) and high adherence to MedDiet (score ≥6). In the group with better adherence to MedDiet, the risk of CVD was lower than in the poor adherence group across all BMI categories.

Bottom Line: An increased risk of CVD across categories of body mass index (BMI) was apparent if adherence to the MedDiet was low, with multivariable-adjusted hazard ratios (HRs): 1.44 (95% confidence interval: 0.93-2.25) for ≥25 - <30 kg/m² of BMI and 2.00 (1.04-3.83) for ≥30 kg/m² of BMI, compared to a BMI < 25 kg/m².Better adherence to the MedDiet was associated with reduced CVD events (p for trend = 0.029).Our results suggest that the MedDiet could mitigate the harmful cardiovascular effect of overweight/obesity.

View Article: PubMed Central - PubMed

Affiliation: Servicio Navarro de Salud-Osasunbidea-IdiSNA, Navarra Institute for Health Research, 31002 Pamplona, Spain. seguaras@alumni.unav.es.

ABSTRACT
Strong observational evidence supports the association between obesity and cardiovascular events. In elderly high-risk subjects, the Mediterranean diet (MedDiet) was reported to counteract the adverse cardiovascular effects of adiposity. Whether this same attenuation is also present in younger subjects is not known. We prospectively examined the association between obesity and cardiovascular clinical events (myocardial infarction, stroke or cardiovascular death) after 10.9 years follow-up in 19,065 middle-aged men and women (average age 38 year) according to their adherence to the MedDiet (<6 points or ≥6 points in the Trichopoulou's Mediterranean Diet Score). We observed 152 incident cases of cardiovascular disease (CVD). An increased risk of CVD across categories of body mass index (BMI) was apparent if adherence to the MedDiet was low, with multivariable-adjusted hazard ratios (HRs): 1.44 (95% confidence interval: 0.93-2.25) for ≥25 - <30 kg/m² of BMI and 2.00 (1.04-3.83) for ≥30 kg/m² of BMI, compared to a BMI < 25 kg/m². In contrast, these estimates were 0.77 (0.35-1.67) and 1.15 (0.39-3.43) with good adherence to MedDiet. Better adherence to the MedDiet was associated with reduced CVD events (p for trend = 0.029). Our results suggest that the MedDiet could mitigate the harmful cardiovascular effect of overweight/obesity.

No MeSH data available.


Related in: MedlinePlus