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Mediterranean Alcohol-Drinking Pattern and the Incidence of Cardiovascular Disease and Cardiovascular Mortality: The SUN Project.

Hernandez-Hernandez A, Gea A, Ruiz-Canela M, Toledo E, Beunza JJ, Bes-Rastrollo M, Martinez-Gonzalez MA - Nutrients (2015)

Bottom Line: Compared with the category of better conformity with the MADP, the low-adherence group exhibited a non-significantly higher risk (HR) of total CVD ((95% CI) = 1.55 (0.58-4.16)).Nevertheless, all these associations were statistically non-significant.Better conformity with the MADP seemed to be associated with lower cardiovascular risk in most point estimates; however, no significant results were found and more powered studies are needed to clarify the role of the MADP on CVD.

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiology, Clínica Universidad de Navarra, 31009 Pamplona, Spain. aitorhernandez86@gmail.com.

ABSTRACT

Background: We assessed the still unclear effect of the overall alcohol-drinking pattern, beyond the amount of alcohol consumed, on the incidence of cardiovascular clinical disease (CVD).

Methods: We followed 14,651 participants during up to 14 years. We built a score assessing simultaneously seven dimensions of alcohol consumption to capture the conformity to a traditional Mediterranean alcohol-drinking pattern (MADP). It positively scored moderate alcohol intake, alcohol intake spread out over the week, low spirit consumption, preference for wine, red wine consumption, wine consumed during meals and avoidance of binge drinking.

Results: During 142,177 person-years of follow-up, 127 incident cases of CVD (myocardial infarction, stroke or cardiovascular mortality) were identified. Compared with the category of better conformity with the MADP, the low-adherence group exhibited a non-significantly higher risk (HR) of total CVD ((95% CI) = 1.55 (0.58-4.16)). This direct association with a departure from the traditional MADP was even stronger for cardiovascular mortality (HR (95% CI) = 3.35 (0.77-14.5)). Nevertheless, all these associations were statistically non-significant.

Conclusion: Better conformity with the MADP seemed to be associated with lower cardiovascular risk in most point estimates; however, no significant results were found and more powered studies are needed to clarify the role of the MADP on CVD.

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Related in: MedlinePlus

Cardiovascular disease (green) and cardiovascular mortality (blue) hazard ratios (HR) and 95% confidence intervals for each component of the Mediterranean alcohol-drinking pattern.
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nutrients-07-05456-f002: Cardiovascular disease (green) and cardiovascular mortality (blue) hazard ratios (HR) and 95% confidence intervals for each component of the Mediterranean alcohol-drinking pattern.

Mentions: In Figure 2 we show the association between each component of MADP and cardiovascular events or cardiovascular mortality. Moderate alcohol intake, low spirit consumption and avoidance of binge drinking (“no excess” in Figure 2) were the items of the MADP score associated with the lowest risks for CVD events or mortality although all these associations were statistically non-significant. However, we observed a significant higher risk of cardiovascular events (HR (95% CI) = 1.71 (1.05–2.78), p = 0.03) and cardiovascular mortality (HR (95% CI) = 3.05 (1.10–8.44), p = 0.03) in participants who did not meet these three characteristics of the MADP compared with those participants who did meet them.


Mediterranean Alcohol-Drinking Pattern and the Incidence of Cardiovascular Disease and Cardiovascular Mortality: The SUN Project.

Hernandez-Hernandez A, Gea A, Ruiz-Canela M, Toledo E, Beunza JJ, Bes-Rastrollo M, Martinez-Gonzalez MA - Nutrients (2015)

Cardiovascular disease (green) and cardiovascular mortality (blue) hazard ratios (HR) and 95% confidence intervals for each component of the Mediterranean alcohol-drinking pattern.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4663584&req=5

nutrients-07-05456-f002: Cardiovascular disease (green) and cardiovascular mortality (blue) hazard ratios (HR) and 95% confidence intervals for each component of the Mediterranean alcohol-drinking pattern.
Mentions: In Figure 2 we show the association between each component of MADP and cardiovascular events or cardiovascular mortality. Moderate alcohol intake, low spirit consumption and avoidance of binge drinking (“no excess” in Figure 2) were the items of the MADP score associated with the lowest risks for CVD events or mortality although all these associations were statistically non-significant. However, we observed a significant higher risk of cardiovascular events (HR (95% CI) = 1.71 (1.05–2.78), p = 0.03) and cardiovascular mortality (HR (95% CI) = 3.05 (1.10–8.44), p = 0.03) in participants who did not meet these three characteristics of the MADP compared with those participants who did meet them.

Bottom Line: Compared with the category of better conformity with the MADP, the low-adherence group exhibited a non-significantly higher risk (HR) of total CVD ((95% CI) = 1.55 (0.58-4.16)).Nevertheless, all these associations were statistically non-significant.Better conformity with the MADP seemed to be associated with lower cardiovascular risk in most point estimates; however, no significant results were found and more powered studies are needed to clarify the role of the MADP on CVD.

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiology, Clínica Universidad de Navarra, 31009 Pamplona, Spain. aitorhernandez86@gmail.com.

ABSTRACT

Background: We assessed the still unclear effect of the overall alcohol-drinking pattern, beyond the amount of alcohol consumed, on the incidence of cardiovascular clinical disease (CVD).

Methods: We followed 14,651 participants during up to 14 years. We built a score assessing simultaneously seven dimensions of alcohol consumption to capture the conformity to a traditional Mediterranean alcohol-drinking pattern (MADP). It positively scored moderate alcohol intake, alcohol intake spread out over the week, low spirit consumption, preference for wine, red wine consumption, wine consumed during meals and avoidance of binge drinking.

Results: During 142,177 person-years of follow-up, 127 incident cases of CVD (myocardial infarction, stroke or cardiovascular mortality) were identified. Compared with the category of better conformity with the MADP, the low-adherence group exhibited a non-significantly higher risk (HR) of total CVD ((95% CI) = 1.55 (0.58-4.16)). This direct association with a departure from the traditional MADP was even stronger for cardiovascular mortality (HR (95% CI) = 3.35 (0.77-14.5)). Nevertheless, all these associations were statistically non-significant.

Conclusion: Better conformity with the MADP seemed to be associated with lower cardiovascular risk in most point estimates; however, no significant results were found and more powered studies are needed to clarify the role of the MADP on CVD.

Show MeSH
Related in: MedlinePlus