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Mediterranean Alcohol-Drinking Pattern and the Incidence of Cardiovascular Disease and Cardiovascular Mortality: The SUN Project.

Hernandez-Hernandez A, Gea A, Ruiz-Canela M, Toledo E, Beunza JJ, Bes-Rastrollo M, Martinez-Gonzalez MA - Nutrients (2015)

Bottom Line: Compared with the category of better conformity with the MADP, the low-adherence group exhibited a non-significantly higher risk (HR) of total CVD ((95% CI) = 1.55 (0.58-4.16)).Nevertheless, all these associations were statistically non-significant.Better conformity with the MADP seemed to be associated with lower cardiovascular risk in most point estimates; however, no significant results were found and more powered studies are needed to clarify the role of the MADP on CVD.

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiology, Clínica Universidad de Navarra, 31009 Pamplona, Spain. aitorhernandez86@gmail.com.

ABSTRACT

Background: We assessed the still unclear effect of the overall alcohol-drinking pattern, beyond the amount of alcohol consumed, on the incidence of cardiovascular clinical disease (CVD).

Methods: We followed 14,651 participants during up to 14 years. We built a score assessing simultaneously seven dimensions of alcohol consumption to capture the conformity to a traditional Mediterranean alcohol-drinking pattern (MADP). It positively scored moderate alcohol intake, alcohol intake spread out over the week, low spirit consumption, preference for wine, red wine consumption, wine consumed during meals and avoidance of binge drinking.

Results: During 142,177 person-years of follow-up, 127 incident cases of CVD (myocardial infarction, stroke or cardiovascular mortality) were identified. Compared with the category of better conformity with the MADP, the low-adherence group exhibited a non-significantly higher risk (HR) of total CVD ((95% CI) = 1.55 (0.58-4.16)). This direct association with a departure from the traditional MADP was even stronger for cardiovascular mortality (HR (95% CI) = 3.35 (0.77-14.5)). Nevertheless, all these associations were statistically non-significant.

Conclusion: Better conformity with the MADP seemed to be associated with lower cardiovascular risk in most point estimates; however, no significant results were found and more powered studies are needed to clarify the role of the MADP on CVD.

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Related in: MedlinePlus

Flow chart of participants. The Seguimiento Universidad de Navarra (SUN) project (1999–2014).
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nutrients-07-05456-f001: Flow chart of participants. The Seguimiento Universidad de Navarra (SUN) project (1999–2014).

Mentions: We assessed 21,291 participants recruited before March 2012, to ensure they completed at least the 2-years follow-up questionnaire. We excluded 245 participants with baseline prevalent cardiovascular events, 1995 participants with total daily energy intake outside of predefined limits (<800 or >4000 Kcal/day among men, and <500 or >3500 Kcal/day among women) [14], and 2726 participants younger than 35 years old who were considered too young to have an alcohol-related cardiovascular event during follow-up. Out of the rest of participants, 1674 were lost to follow-up (retention in the cohort: 89.7%), leading to a final sample of 14,651 participants (Figure 1).


Mediterranean Alcohol-Drinking Pattern and the Incidence of Cardiovascular Disease and Cardiovascular Mortality: The SUN Project.

Hernandez-Hernandez A, Gea A, Ruiz-Canela M, Toledo E, Beunza JJ, Bes-Rastrollo M, Martinez-Gonzalez MA - Nutrients (2015)

Flow chart of participants. The Seguimiento Universidad de Navarra (SUN) project (1999–2014).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4663584&req=5

nutrients-07-05456-f001: Flow chart of participants. The Seguimiento Universidad de Navarra (SUN) project (1999–2014).
Mentions: We assessed 21,291 participants recruited before March 2012, to ensure they completed at least the 2-years follow-up questionnaire. We excluded 245 participants with baseline prevalent cardiovascular events, 1995 participants with total daily energy intake outside of predefined limits (<800 or >4000 Kcal/day among men, and <500 or >3500 Kcal/day among women) [14], and 2726 participants younger than 35 years old who were considered too young to have an alcohol-related cardiovascular event during follow-up. Out of the rest of participants, 1674 were lost to follow-up (retention in the cohort: 89.7%), leading to a final sample of 14,651 participants (Figure 1).

Bottom Line: Compared with the category of better conformity with the MADP, the low-adherence group exhibited a non-significantly higher risk (HR) of total CVD ((95% CI) = 1.55 (0.58-4.16)).Nevertheless, all these associations were statistically non-significant.Better conformity with the MADP seemed to be associated with lower cardiovascular risk in most point estimates; however, no significant results were found and more powered studies are needed to clarify the role of the MADP on CVD.

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiology, Clínica Universidad de Navarra, 31009 Pamplona, Spain. aitorhernandez86@gmail.com.

ABSTRACT

Background: We assessed the still unclear effect of the overall alcohol-drinking pattern, beyond the amount of alcohol consumed, on the incidence of cardiovascular clinical disease (CVD).

Methods: We followed 14,651 participants during up to 14 years. We built a score assessing simultaneously seven dimensions of alcohol consumption to capture the conformity to a traditional Mediterranean alcohol-drinking pattern (MADP). It positively scored moderate alcohol intake, alcohol intake spread out over the week, low spirit consumption, preference for wine, red wine consumption, wine consumed during meals and avoidance of binge drinking.

Results: During 142,177 person-years of follow-up, 127 incident cases of CVD (myocardial infarction, stroke or cardiovascular mortality) were identified. Compared with the category of better conformity with the MADP, the low-adherence group exhibited a non-significantly higher risk (HR) of total CVD ((95% CI) = 1.55 (0.58-4.16)). This direct association with a departure from the traditional MADP was even stronger for cardiovascular mortality (HR (95% CI) = 3.35 (0.77-14.5)). Nevertheless, all these associations were statistically non-significant.

Conclusion: Better conformity with the MADP seemed to be associated with lower cardiovascular risk in most point estimates; however, no significant results were found and more powered studies are needed to clarify the role of the MADP on CVD.

Show MeSH
Related in: MedlinePlus