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Oral Fat Sensing and CD36 Gene Polymorphism in Algerian Lean and Obese Teenagers.

Daoudi H, Plesník J, Sayed A, Šerý O, Rouabah A, Rouabah L, Khan NA - Nutrients (2015)

Bottom Line: Indeed, a decreased expression of CD36 in some obese subjects is associated with high dietary fat intake.The obese teenagers (n = 83; 14.01 ± 0.19 years; BMI z-score 2.67 ± 0.29) exhibited higher lingual detection threshold for oleic acid than lean participants (n = 82, 13.92 ± 0.23 years; BMI z-score 0.03 ± 0.0001).The A-allele frequency was higher in obese teenagers than that in lean children.

View Article: PubMed Central - PubMed

Affiliation: Laborartoire de Biologie Cellulaire & Moléculaire, Université de Constantine 1, Constantine 25000, Alegria. hadjer25dz@hotmail.com.

ABSTRACT
Growing number of evidences have suggested that oral fat sensing, mediated by a glycoprotein CD36 (cluster of differentiation 36), plays a significant role in the development of obesity. Indeed, a decreased expression of CD36 in some obese subjects is associated with high dietary fat intake. In the present study, we examined whether an increase in body mass index (BMI) is associated with altered oleic acid lingual detection thresholds and blood lipid profile in young Algerian teenagers (n = 165). The obese teenagers (n = 83; 14.01 ± 0.19 years; BMI z-score 2.67 ± 0.29) exhibited higher lingual detection threshold for oleic acid than lean participants (n = 82, 13.92 ± 0.23 years; BMI z-score 0.03 ± 0.0001). We also studied the association between rs1761667 polymorphism of CD36 gene and obesity. The AA and AG genotypes were more frequent in obese teenagers, whereas GG genotype was more common in lean participants. The A-allele frequency was higher in obese teenagers than that in lean children. We report that rs1761667 polymorphism of CD36 gene and oro-gustatory thresholds for fat might play a significant role in the development of obesity in young teenagers.

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Rs1761667 genotypes separated on 2% agarose gel and stained with ethidium bromide. The blot shows one identical photograph from several reproduced ones.
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nutrients-07-05455-f003: Rs1761667 genotypes separated on 2% agarose gel and stained with ethidium bromide. The blot shows one identical photograph from several reproduced ones.

Mentions: Figure 3 shows rs1761667 genotypes on agarose gel. We did not observe any deviation from Hardy-Weinberg equilibrium (p > 0.05) in lean and obese participants (Table 2) in genotype frequencies of rs1761667 polymorphism of CD36 gene. The frequencies of A-allele in lean and obese groups were 56.7% and 68.1%, respectively (p = 0.041, OR = 1.63; 95% CI of OR = 1.04–2.55). AA and AG genotypes are present predominantly in obese teenagers (p = 0.008; p = 0.002, respectively). Minor genotype was, on the other hand, present in the controls. We did not find any significant difference between CD36 genotype and oleic acid oral sensitivity threshold. Similarly, we did not observe any significant difference between CD36 genotypes and BMI z-score neither in obese nor control teenagers (p = 0.58; p = 0.41, respectively). We did not find any significant difference between the genders.


Oral Fat Sensing and CD36 Gene Polymorphism in Algerian Lean and Obese Teenagers.

Daoudi H, Plesník J, Sayed A, Šerý O, Rouabah A, Rouabah L, Khan NA - Nutrients (2015)

Rs1761667 genotypes separated on 2% agarose gel and stained with ethidium bromide. The blot shows one identical photograph from several reproduced ones.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4663583&req=5

nutrients-07-05455-f003: Rs1761667 genotypes separated on 2% agarose gel and stained with ethidium bromide. The blot shows one identical photograph from several reproduced ones.
Mentions: Figure 3 shows rs1761667 genotypes on agarose gel. We did not observe any deviation from Hardy-Weinberg equilibrium (p > 0.05) in lean and obese participants (Table 2) in genotype frequencies of rs1761667 polymorphism of CD36 gene. The frequencies of A-allele in lean and obese groups were 56.7% and 68.1%, respectively (p = 0.041, OR = 1.63; 95% CI of OR = 1.04–2.55). AA and AG genotypes are present predominantly in obese teenagers (p = 0.008; p = 0.002, respectively). Minor genotype was, on the other hand, present in the controls. We did not find any significant difference between CD36 genotype and oleic acid oral sensitivity threshold. Similarly, we did not observe any significant difference between CD36 genotypes and BMI z-score neither in obese nor control teenagers (p = 0.58; p = 0.41, respectively). We did not find any significant difference between the genders.

Bottom Line: Indeed, a decreased expression of CD36 in some obese subjects is associated with high dietary fat intake.The obese teenagers (n = 83; 14.01 ± 0.19 years; BMI z-score 2.67 ± 0.29) exhibited higher lingual detection threshold for oleic acid than lean participants (n = 82, 13.92 ± 0.23 years; BMI z-score 0.03 ± 0.0001).The A-allele frequency was higher in obese teenagers than that in lean children.

View Article: PubMed Central - PubMed

Affiliation: Laborartoire de Biologie Cellulaire & Moléculaire, Université de Constantine 1, Constantine 25000, Alegria. hadjer25dz@hotmail.com.

ABSTRACT
Growing number of evidences have suggested that oral fat sensing, mediated by a glycoprotein CD36 (cluster of differentiation 36), plays a significant role in the development of obesity. Indeed, a decreased expression of CD36 in some obese subjects is associated with high dietary fat intake. In the present study, we examined whether an increase in body mass index (BMI) is associated with altered oleic acid lingual detection thresholds and blood lipid profile in young Algerian teenagers (n = 165). The obese teenagers (n = 83; 14.01 ± 0.19 years; BMI z-score 2.67 ± 0.29) exhibited higher lingual detection threshold for oleic acid than lean participants (n = 82, 13.92 ± 0.23 years; BMI z-score 0.03 ± 0.0001). We also studied the association between rs1761667 polymorphism of CD36 gene and obesity. The AA and AG genotypes were more frequent in obese teenagers, whereas GG genotype was more common in lean participants. The A-allele frequency was higher in obese teenagers than that in lean children. We report that rs1761667 polymorphism of CD36 gene and oro-gustatory thresholds for fat might play a significant role in the development of obesity in young teenagers.

Show MeSH
Related in: MedlinePlus