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Oral Fat Sensing and CD36 Gene Polymorphism in Algerian Lean and Obese Teenagers.

Daoudi H, Plesník J, Sayed A, Šerý O, Rouabah A, Rouabah L, Khan NA - Nutrients (2015)

Bottom Line: Indeed, a decreased expression of CD36 in some obese subjects is associated with high dietary fat intake.The obese teenagers (n = 83; 14.01 ± 0.19 years; BMI z-score 2.67 ± 0.29) exhibited higher lingual detection threshold for oleic acid than lean participants (n = 82, 13.92 ± 0.23 years; BMI z-score 0.03 ± 0.0001).The A-allele frequency was higher in obese teenagers than that in lean children.

View Article: PubMed Central - PubMed

Affiliation: Laborartoire de Biologie Cellulaire & Moléculaire, Université de Constantine 1, Constantine 25000, Alegria. hadjer25dz@hotmail.com.

ABSTRACT
Growing number of evidences have suggested that oral fat sensing, mediated by a glycoprotein CD36 (cluster of differentiation 36), plays a significant role in the development of obesity. Indeed, a decreased expression of CD36 in some obese subjects is associated with high dietary fat intake. In the present study, we examined whether an increase in body mass index (BMI) is associated with altered oleic acid lingual detection thresholds and blood lipid profile in young Algerian teenagers (n = 165). The obese teenagers (n = 83; 14.01 ± 0.19 years; BMI z-score 2.67 ± 0.29) exhibited higher lingual detection threshold for oleic acid than lean participants (n = 82, 13.92 ± 0.23 years; BMI z-score 0.03 ± 0.0001). We also studied the association between rs1761667 polymorphism of CD36 gene and obesity. The AA and AG genotypes were more frequent in obese teenagers, whereas GG genotype was more common in lean participants. The A-allele frequency was higher in obese teenagers than that in lean children. We report that rs1761667 polymorphism of CD36 gene and oro-gustatory thresholds for fat might play a significant role in the development of obesity in young teenagers.

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Fatty acid sensitivity in all young teenagers in relation to BMI. The lean and obese children (n = 165) were divided into three groups on the basis of oro-sensory detection of oleic acid as high, middle, and low tasters. “High tasters” group contained lean teenagers only (n = 8), most of the teenagers from the both groups (control, n = 60; obese, n = 45) belonged to the “Middle tasters” group and the “Low tasters” group consisted predominantly of obese participants (n = 41) and controls (n = 11). The results are means ± SEM.
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nutrients-07-05455-f002: Fatty acid sensitivity in all young teenagers in relation to BMI. The lean and obese children (n = 165) were divided into three groups on the basis of oro-sensory detection of oleic acid as high, middle, and low tasters. “High tasters” group contained lean teenagers only (n = 8), most of the teenagers from the both groups (control, n = 60; obese, n = 45) belonged to the “Middle tasters” group and the “Low tasters” group consisted predominantly of obese participants (n = 41) and controls (n = 11). The results are means ± SEM.

Mentions: We observed statistically significant difference in oleic acid oral detection threshold between obese and lean adolescents (Figure 1). Obese subjects exhibited almost twofold OA detection threshold (2.57 ± 0.29 mmol/L, p < 0.01) than lean participants (1.33 ± 0.15 mmol/L). We noticed a positive correlation between BMI z-score and OA detection (p < 0.01). If we divide all the participants, on the basis of oral detection thresholds, into three categories: high tasters (between 0 to 0.018 mM), middle tasters (between 0.18 and 1.5 mM), and low tasters (between 3 and 12 mM), we notice a relationship between BMI and fat taste thresholds (p < 0.001; Figure 2). We did not find any significant difference in the measured parameters between genders.


Oral Fat Sensing and CD36 Gene Polymorphism in Algerian Lean and Obese Teenagers.

Daoudi H, Plesník J, Sayed A, Šerý O, Rouabah A, Rouabah L, Khan NA - Nutrients (2015)

Fatty acid sensitivity in all young teenagers in relation to BMI. The lean and obese children (n = 165) were divided into three groups on the basis of oro-sensory detection of oleic acid as high, middle, and low tasters. “High tasters” group contained lean teenagers only (n = 8), most of the teenagers from the both groups (control, n = 60; obese, n = 45) belonged to the “Middle tasters” group and the “Low tasters” group consisted predominantly of obese participants (n = 41) and controls (n = 11). The results are means ± SEM.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4663583&req=5

nutrients-07-05455-f002: Fatty acid sensitivity in all young teenagers in relation to BMI. The lean and obese children (n = 165) were divided into three groups on the basis of oro-sensory detection of oleic acid as high, middle, and low tasters. “High tasters” group contained lean teenagers only (n = 8), most of the teenagers from the both groups (control, n = 60; obese, n = 45) belonged to the “Middle tasters” group and the “Low tasters” group consisted predominantly of obese participants (n = 41) and controls (n = 11). The results are means ± SEM.
Mentions: We observed statistically significant difference in oleic acid oral detection threshold between obese and lean adolescents (Figure 1). Obese subjects exhibited almost twofold OA detection threshold (2.57 ± 0.29 mmol/L, p < 0.01) than lean participants (1.33 ± 0.15 mmol/L). We noticed a positive correlation between BMI z-score and OA detection (p < 0.01). If we divide all the participants, on the basis of oral detection thresholds, into three categories: high tasters (between 0 to 0.018 mM), middle tasters (between 0.18 and 1.5 mM), and low tasters (between 3 and 12 mM), we notice a relationship between BMI and fat taste thresholds (p < 0.001; Figure 2). We did not find any significant difference in the measured parameters between genders.

Bottom Line: Indeed, a decreased expression of CD36 in some obese subjects is associated with high dietary fat intake.The obese teenagers (n = 83; 14.01 ± 0.19 years; BMI z-score 2.67 ± 0.29) exhibited higher lingual detection threshold for oleic acid than lean participants (n = 82, 13.92 ± 0.23 years; BMI z-score 0.03 ± 0.0001).The A-allele frequency was higher in obese teenagers than that in lean children.

View Article: PubMed Central - PubMed

Affiliation: Laborartoire de Biologie Cellulaire & Moléculaire, Université de Constantine 1, Constantine 25000, Alegria. hadjer25dz@hotmail.com.

ABSTRACT
Growing number of evidences have suggested that oral fat sensing, mediated by a glycoprotein CD36 (cluster of differentiation 36), plays a significant role in the development of obesity. Indeed, a decreased expression of CD36 in some obese subjects is associated with high dietary fat intake. In the present study, we examined whether an increase in body mass index (BMI) is associated with altered oleic acid lingual detection thresholds and blood lipid profile in young Algerian teenagers (n = 165). The obese teenagers (n = 83; 14.01 ± 0.19 years; BMI z-score 2.67 ± 0.29) exhibited higher lingual detection threshold for oleic acid than lean participants (n = 82, 13.92 ± 0.23 years; BMI z-score 0.03 ± 0.0001). We also studied the association between rs1761667 polymorphism of CD36 gene and obesity. The AA and AG genotypes were more frequent in obese teenagers, whereas GG genotype was more common in lean participants. The A-allele frequency was higher in obese teenagers than that in lean children. We report that rs1761667 polymorphism of CD36 gene and oro-gustatory thresholds for fat might play a significant role in the development of obesity in young teenagers.

Show MeSH
Related in: MedlinePlus