Limits...
Synergistic Effects of Human Milk Nutrients in the Support of Infant Recognition Memory: An Observational Study.

Cheatham CL, Sheppard KW - Nutrients (2015)

Bottom Line: The DHA X free choline interaction was also significant for the difference in latency scores at frontal, central, and midline areas (p < 0.01; p < 0.001; p < 0.05 respectively).Higher choline with higher DHA was related to better recognition memory.Interactions between human milk nutrients appear important in predicting infant cognition, and there may be a benefit to specific nutrient combinations.

View Article: PubMed Central - PubMed

Affiliation: Nutrition Research Institute, University of North Carolina at Chapel Hill, Kannapolis, NC 28081, USA. carol_cheatham@unc.edu.

ABSTRACT
The aim was to explore the relation of human milk lutein; choline; and docosahexaenoic acid (DHA) with recognition memory abilities of six-month-olds. Milk samples obtained three to four months postpartum were analyzed for fatty acids, lutein, and choline. At six months, participants were invited to an electrophysiology session. Recognition memory was tested with a 70-30 oddball paradigm in a high-density 128-lead event-related potential (ERP) paradigm. Complete data were available for 55 participants. Data were averaged at six groupings (Frontal Right; Frontal Central; Frontal Left; Central; Midline; and Parietal) for latency to peak, peak amplitude, and mean amplitude. Difference scores were calculated as familiar minus novel. Final regression models revealed the lutein X free choline interaction was significant for the difference in latency scores at frontal and central areas (p < 0.05 and p < 0.001; respectively). Higher choline levels with higher lutein levels were related to better recognition memory. The DHA X free choline interaction was also significant for the difference in latency scores at frontal, central, and midline areas (p < 0.01; p < 0.001; p < 0.05 respectively). Higher choline with higher DHA was related to better recognition memory. Interactions between human milk nutrients appear important in predicting infant cognition, and there may be a benefit to specific nutrient combinations.

Show MeSH

Related in: MedlinePlus

Sensor map showing the clusters used in analyses: FrontalZ (4, 10, 11, 16, 18, 19), FrontalL (24, 27, 28, 34, 33), FrontalR (116, 117, 122, 123, 124), CentralZ (7, 31, 55, 80, 106, REF), ParietalZ (61, 62, 67, 72, 77, 78), and Midline (6, 11, 15, 16, 55, REF).
© Copyright Policy
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4663580&req=5

nutrients-07-05452-f001: Sensor map showing the clusters used in analyses: FrontalZ (4, 10, 11, 16, 18, 19), FrontalL (24, 27, 28, 34, 33), FrontalR (116, 117, 122, 123, 124), CentralZ (7, 31, 55, 80, 106, REF), ParietalZ (61, 62, 67, 72, 77, 78), and Midline (6, 11, 15, 16, 55, REF).

Mentions: The grand mean file was visually examined, and a negative deflection window of interest was chosen at 200 to 900 ms from stimulus onset. Visual inspection of the continuous data and review of the literature e.g., [33] provided support for sensor clusters of interest. Data were averaged across sensor groups as follows (see Figure 1): FrontalZ (4, 10, 11, 16, 18, 19), FrontalL (24, 27, 28, 34, 33), FrontalR (116, 117, 122, 123, 124), CentralZ (7, 31, 55, 80, 106, REF), ParietalZ (61, 62, 67, 72, 77, 78), and Midline (6, 11, 15, 16, 55, REF). Clusters were individually assessed for mean amplitude, peak amplitude, and latency to peak amplitude within the 200 to 900 ms window for each condition using NetStation 4.5.4 (Electrical Geodesic, Inc., Eugene, OR, USA). In SAS 9.2 (SAS Institute, Inc., Cary, NC, USA), difference variables were computed for each variable from each cluster by subtracting data for novel unique from data for familiar data.


Synergistic Effects of Human Milk Nutrients in the Support of Infant Recognition Memory: An Observational Study.

Cheatham CL, Sheppard KW - Nutrients (2015)

Sensor map showing the clusters used in analyses: FrontalZ (4, 10, 11, 16, 18, 19), FrontalL (24, 27, 28, 34, 33), FrontalR (116, 117, 122, 123, 124), CentralZ (7, 31, 55, 80, 106, REF), ParietalZ (61, 62, 67, 72, 77, 78), and Midline (6, 11, 15, 16, 55, REF).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4663580&req=5

nutrients-07-05452-f001: Sensor map showing the clusters used in analyses: FrontalZ (4, 10, 11, 16, 18, 19), FrontalL (24, 27, 28, 34, 33), FrontalR (116, 117, 122, 123, 124), CentralZ (7, 31, 55, 80, 106, REF), ParietalZ (61, 62, 67, 72, 77, 78), and Midline (6, 11, 15, 16, 55, REF).
Mentions: The grand mean file was visually examined, and a negative deflection window of interest was chosen at 200 to 900 ms from stimulus onset. Visual inspection of the continuous data and review of the literature e.g., [33] provided support for sensor clusters of interest. Data were averaged across sensor groups as follows (see Figure 1): FrontalZ (4, 10, 11, 16, 18, 19), FrontalL (24, 27, 28, 34, 33), FrontalR (116, 117, 122, 123, 124), CentralZ (7, 31, 55, 80, 106, REF), ParietalZ (61, 62, 67, 72, 77, 78), and Midline (6, 11, 15, 16, 55, REF). Clusters were individually assessed for mean amplitude, peak amplitude, and latency to peak amplitude within the 200 to 900 ms window for each condition using NetStation 4.5.4 (Electrical Geodesic, Inc., Eugene, OR, USA). In SAS 9.2 (SAS Institute, Inc., Cary, NC, USA), difference variables were computed for each variable from each cluster by subtracting data for novel unique from data for familiar data.

Bottom Line: The DHA X free choline interaction was also significant for the difference in latency scores at frontal, central, and midline areas (p < 0.01; p < 0.001; p < 0.05 respectively).Higher choline with higher DHA was related to better recognition memory.Interactions between human milk nutrients appear important in predicting infant cognition, and there may be a benefit to specific nutrient combinations.

View Article: PubMed Central - PubMed

Affiliation: Nutrition Research Institute, University of North Carolina at Chapel Hill, Kannapolis, NC 28081, USA. carol_cheatham@unc.edu.

ABSTRACT
The aim was to explore the relation of human milk lutein; choline; and docosahexaenoic acid (DHA) with recognition memory abilities of six-month-olds. Milk samples obtained three to four months postpartum were analyzed for fatty acids, lutein, and choline. At six months, participants were invited to an electrophysiology session. Recognition memory was tested with a 70-30 oddball paradigm in a high-density 128-lead event-related potential (ERP) paradigm. Complete data were available for 55 participants. Data were averaged at six groupings (Frontal Right; Frontal Central; Frontal Left; Central; Midline; and Parietal) for latency to peak, peak amplitude, and mean amplitude. Difference scores were calculated as familiar minus novel. Final regression models revealed the lutein X free choline interaction was significant for the difference in latency scores at frontal and central areas (p < 0.05 and p < 0.001; respectively). Higher choline levels with higher lutein levels were related to better recognition memory. The DHA X free choline interaction was also significant for the difference in latency scores at frontal, central, and midline areas (p < 0.01; p < 0.001; p < 0.05 respectively). Higher choline with higher DHA was related to better recognition memory. Interactions between human milk nutrients appear important in predicting infant cognition, and there may be a benefit to specific nutrient combinations.

Show MeSH
Related in: MedlinePlus