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Effects of Four-Week Supplementation with a Multi-Vitamin/Mineral Preparation on Mood and Blood Biomarkers in Young Adults: A Randomised, Double-Blind, Placebo-Controlled Trial.

White DJ, Cox KH, Peters R, Pipingas A, Scholey AB - Nutrients (2015)

Bottom Line: This study explored the effects of four-week multi-vitamin and mineral (MVM) supplementation on mood and neurocognitive function in healthy, young adults.MVM treatment was also associated with significantly improved mood, as measured by reduced scores on the "depression-dejection" subscale of the Profile of Mood States (p = 0.018).These findings suggest that the four weeks of MVM supplementation may have beneficial effects on mood, underpinned by elevated B-vitamins and lowered homocysteine in healthy young adults.

View Article: PubMed Central - PubMed

Affiliation: Centre for Human Psychopharmacology, Swinburne University of Technology, Hawthorn, VIC 3122, Australia. dawhite@swin.edu.au.

ABSTRACT
This study explored the effects of four-week multi-vitamin and mineral (MVM) supplementation on mood and neurocognitive function in healthy, young adults. Fifty-eight healthy adults, 18-40 years of age (M = 25.82 years, SD = 4.87) participated in this randomised, double-blind, placebo-controlled trial, in which mood and blood biomarkers were assessed at baseline and after four weeks of supplementation. Compared to placebo, MVM supplementation was associated with significantly lowered homocysteine and increased blood B-vitamin levels (p < 0.01). MVM treatment was also associated with significantly improved mood, as measured by reduced scores on the "depression-dejection" subscale of the Profile of Mood States (p = 0.018). These findings suggest that the four weeks of MVM supplementation may have beneficial effects on mood, underpinned by elevated B-vitamins and lowered homocysteine in healthy young adults.

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Related in: MedlinePlus

Post-treatment depression/dejection scores (POMS), adjusting for baseline (estimated marginal means, error bars ± 1 SE). MVM: Multivitamin/mineral treatment group.
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nutrients-07-05451-f002: Post-treatment depression/dejection scores (POMS), adjusting for baseline (estimated marginal means, error bars ± 1 SE). MVM: Multivitamin/mineral treatment group.

Mentions: An analysis of covariance, examining mood post-treatment, controlling for baseline, found that MVM treatment was associated with significantly lower scores on the depression/dejection subscale of the POMS, compared to placebo (F(1,48) = 5.96, p = 0.018, partial η2 = 0.11; see Table 4 and Figure 2). There was no significant effect of treatment on other POMS subscales, nor total mood disturbance, nor the PSS (Table 4). Whilst underpowered for the exploration of treatment effects within gender, based on previous research in males demonstrating a positive effect of supplementation on PSS scores [26], this scale was probed for males separately. A non-significant trend towards lower PSS scores was observed after MVM supplementation (adjusted M = 11.41, SE = 1.17) compared to placebo (adjusted M = 14.12, SE = 1.14; F(1,27) = 2.76, p = 0.110, partial η2 = 0.103).


Effects of Four-Week Supplementation with a Multi-Vitamin/Mineral Preparation on Mood and Blood Biomarkers in Young Adults: A Randomised, Double-Blind, Placebo-Controlled Trial.

White DJ, Cox KH, Peters R, Pipingas A, Scholey AB - Nutrients (2015)

Post-treatment depression/dejection scores (POMS), adjusting for baseline (estimated marginal means, error bars ± 1 SE). MVM: Multivitamin/mineral treatment group.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4663579&req=5

nutrients-07-05451-f002: Post-treatment depression/dejection scores (POMS), adjusting for baseline (estimated marginal means, error bars ± 1 SE). MVM: Multivitamin/mineral treatment group.
Mentions: An analysis of covariance, examining mood post-treatment, controlling for baseline, found that MVM treatment was associated with significantly lower scores on the depression/dejection subscale of the POMS, compared to placebo (F(1,48) = 5.96, p = 0.018, partial η2 = 0.11; see Table 4 and Figure 2). There was no significant effect of treatment on other POMS subscales, nor total mood disturbance, nor the PSS (Table 4). Whilst underpowered for the exploration of treatment effects within gender, based on previous research in males demonstrating a positive effect of supplementation on PSS scores [26], this scale was probed for males separately. A non-significant trend towards lower PSS scores was observed after MVM supplementation (adjusted M = 11.41, SE = 1.17) compared to placebo (adjusted M = 14.12, SE = 1.14; F(1,27) = 2.76, p = 0.110, partial η2 = 0.103).

Bottom Line: This study explored the effects of four-week multi-vitamin and mineral (MVM) supplementation on mood and neurocognitive function in healthy, young adults.MVM treatment was also associated with significantly improved mood, as measured by reduced scores on the "depression-dejection" subscale of the Profile of Mood States (p = 0.018).These findings suggest that the four weeks of MVM supplementation may have beneficial effects on mood, underpinned by elevated B-vitamins and lowered homocysteine in healthy young adults.

View Article: PubMed Central - PubMed

Affiliation: Centre for Human Psychopharmacology, Swinburne University of Technology, Hawthorn, VIC 3122, Australia. dawhite@swin.edu.au.

ABSTRACT
This study explored the effects of four-week multi-vitamin and mineral (MVM) supplementation on mood and neurocognitive function in healthy, young adults. Fifty-eight healthy adults, 18-40 years of age (M = 25.82 years, SD = 4.87) participated in this randomised, double-blind, placebo-controlled trial, in which mood and blood biomarkers were assessed at baseline and after four weeks of supplementation. Compared to placebo, MVM supplementation was associated with significantly lowered homocysteine and increased blood B-vitamin levels (p < 0.01). MVM treatment was also associated with significantly improved mood, as measured by reduced scores on the "depression-dejection" subscale of the Profile of Mood States (p = 0.018). These findings suggest that the four weeks of MVM supplementation may have beneficial effects on mood, underpinned by elevated B-vitamins and lowered homocysteine in healthy young adults.

Show MeSH
Related in: MedlinePlus