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Effects of Four-Week Supplementation with a Multi-Vitamin/Mineral Preparation on Mood and Blood Biomarkers in Young Adults: A Randomised, Double-Blind, Placebo-Controlled Trial.

White DJ, Cox KH, Peters R, Pipingas A, Scholey AB - Nutrients (2015)

Bottom Line: This study explored the effects of four-week multi-vitamin and mineral (MVM) supplementation on mood and neurocognitive function in healthy, young adults.MVM treatment was also associated with significantly improved mood, as measured by reduced scores on the "depression-dejection" subscale of the Profile of Mood States (p = 0.018).These findings suggest that the four weeks of MVM supplementation may have beneficial effects on mood, underpinned by elevated B-vitamins and lowered homocysteine in healthy young adults.

View Article: PubMed Central - PubMed

Affiliation: Centre for Human Psychopharmacology, Swinburne University of Technology, Hawthorn, VIC 3122, Australia. dawhite@swin.edu.au.

ABSTRACT
This study explored the effects of four-week multi-vitamin and mineral (MVM) supplementation on mood and neurocognitive function in healthy, young adults. Fifty-eight healthy adults, 18-40 years of age (M = 25.82 years, SD = 4.87) participated in this randomised, double-blind, placebo-controlled trial, in which mood and blood biomarkers were assessed at baseline and after four weeks of supplementation. Compared to placebo, MVM supplementation was associated with significantly lowered homocysteine and increased blood B-vitamin levels (p < 0.01). MVM treatment was also associated with significantly improved mood, as measured by reduced scores on the "depression-dejection" subscale of the Profile of Mood States (p = 0.018). These findings suggest that the four weeks of MVM supplementation may have beneficial effects on mood, underpinned by elevated B-vitamins and lowered homocysteine in healthy young adults.

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Flow of participants through the trial.
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nutrients-07-05451-f001: Flow of participants through the trial.

Mentions: A total of 58 healthy young adults aged 18–39 years (M = 25.82, SD = 4.87) were enrolled in the study, with 55 completing the follow-up assessment. Participants were recruited via local media advertising. A history or current diagnosis of psychiatric disorder, heart disease, high blood pressure, diabetes or any condition that may interfere with normal food metabolism (for example, relevant food allergies or irritable bowel syndrome) were considered criteria for exclusion. Participants were also required to not be taking medication, herbal extracts, vitamin supplements or illicit drugs within 4 weeks prior to (and for the duration of) the study, with the exception of contraceptive pills or routine medications to treat benign conditions. The flow of participants through the trial is summarized in Figure 1 below.


Effects of Four-Week Supplementation with a Multi-Vitamin/Mineral Preparation on Mood and Blood Biomarkers in Young Adults: A Randomised, Double-Blind, Placebo-Controlled Trial.

White DJ, Cox KH, Peters R, Pipingas A, Scholey AB - Nutrients (2015)

Flow of participants through the trial.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4663579&req=5

nutrients-07-05451-f001: Flow of participants through the trial.
Mentions: A total of 58 healthy young adults aged 18–39 years (M = 25.82, SD = 4.87) were enrolled in the study, with 55 completing the follow-up assessment. Participants were recruited via local media advertising. A history or current diagnosis of psychiatric disorder, heart disease, high blood pressure, diabetes or any condition that may interfere with normal food metabolism (for example, relevant food allergies or irritable bowel syndrome) were considered criteria for exclusion. Participants were also required to not be taking medication, herbal extracts, vitamin supplements or illicit drugs within 4 weeks prior to (and for the duration of) the study, with the exception of contraceptive pills or routine medications to treat benign conditions. The flow of participants through the trial is summarized in Figure 1 below.

Bottom Line: This study explored the effects of four-week multi-vitamin and mineral (MVM) supplementation on mood and neurocognitive function in healthy, young adults.MVM treatment was also associated with significantly improved mood, as measured by reduced scores on the "depression-dejection" subscale of the Profile of Mood States (p = 0.018).These findings suggest that the four weeks of MVM supplementation may have beneficial effects on mood, underpinned by elevated B-vitamins and lowered homocysteine in healthy young adults.

View Article: PubMed Central - PubMed

Affiliation: Centre for Human Psychopharmacology, Swinburne University of Technology, Hawthorn, VIC 3122, Australia. dawhite@swin.edu.au.

ABSTRACT
This study explored the effects of four-week multi-vitamin and mineral (MVM) supplementation on mood and neurocognitive function in healthy, young adults. Fifty-eight healthy adults, 18-40 years of age (M = 25.82 years, SD = 4.87) participated in this randomised, double-blind, placebo-controlled trial, in which mood and blood biomarkers were assessed at baseline and after four weeks of supplementation. Compared to placebo, MVM supplementation was associated with significantly lowered homocysteine and increased blood B-vitamin levels (p < 0.01). MVM treatment was also associated with significantly improved mood, as measured by reduced scores on the "depression-dejection" subscale of the Profile of Mood States (p = 0.018). These findings suggest that the four weeks of MVM supplementation may have beneficial effects on mood, underpinned by elevated B-vitamins and lowered homocysteine in healthy young adults.

Show MeSH