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Effects of Fructans from Mexican Agave in Newborns Fed with Infant Formula: A Randomized Controlled Trial.

López-Velázquez G, Parra-Ortiz M, Mora Ide L, García-Torres I, Enríquez-Flores S, Alcántara-Ortigoza MA, Angel AG, Velázquez-Aragón J, Ortiz-Hernández R, Cruz-Rubio JM, Villa-Barragán P, Jiménez-Gutiérrez C, Gutiérrez-Castrellón P - Nutrients (2015)

Bottom Line: The importance of prebiotics consumption is increasing all over the world due to their beneficial effects on health.Recently, the safety in humans of two fructans obtained from Agave tequilana (Metlin(®) and Metlos(®)) was demonstrated.Our results support the efficacy of Metlin(®) and Metlos(®) as prebiotics in humans, and stand the bases to recommend their consumption.

View Article: PubMed Central - PubMed

Affiliation: Laboratorio de Bioquímica-Genética, Instituto Nacional de Pediatría, Mexico City 04530, México. glv_1999@yahoo.com.

ABSTRACT

Background: The importance of prebiotics consumption is increasing all over the world due to their beneficial effects on health. Production of better prebiotics from endemic plants raises possibilities to enhance nutritional effects in vulnerable population groups. Fructans derived from Agave Plant have demonstrated their safety and efficacy as prebiotics in animal models. Recently, the safety in humans of two fructans obtained from Agave tequilana (Metlin(®) and Metlos(®)) was demonstrated.

Methods: This study aimed to demonstrate the efficacy as prebiotics of Metlin(®) and Metlos(®) in newborns of a randomized, double blind, controlled trial with a pilot study design. Biological samples were taken at 20 ± 7 days, and three months of age from healthy babies. Outcomes of efficacy include impact on immune response, serum ferritin, C-reactive protein, bone metabolism, and gut bacteria changes.

Results: There were differences statistically significant for the groups of infants fed only with infant formula and with formula enriched with Metlin(®) and Metlos(®).

Conclusions: Our results support the efficacy of Metlin(®) and Metlos(®) as prebiotics in humans, and stand the bases to recommend their consumption.

Trial registration: ClinicalTrials.gov, NCT 01251783.

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Related in: MedlinePlus

Clostridium population changes after three months of age in the different groups of study.
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nutrients-07-05442-f002: Clostridium population changes after three months of age in the different groups of study.

Mentions: Although Clostridium showed low quantities in all the groups, the most evident differences were between those groups fed with breast milk or formula added with fructans than those fed with formula without fructans (Figure 2). In fact, Clostridium population in those babies fed with formula alone was 57 times higher than those of reference group or groups containing fructans in the formula. In the group fed with formula + Probiotic, Clostridium population was 15 times higher than in the others. Between reference group (breast milk feeding) and groups fed with any of the tested fructans, the relative abundance of Clostridium was almost the same.


Effects of Fructans from Mexican Agave in Newborns Fed with Infant Formula: A Randomized Controlled Trial.

López-Velázquez G, Parra-Ortiz M, Mora Ide L, García-Torres I, Enríquez-Flores S, Alcántara-Ortigoza MA, Angel AG, Velázquez-Aragón J, Ortiz-Hernández R, Cruz-Rubio JM, Villa-Barragán P, Jiménez-Gutiérrez C, Gutiérrez-Castrellón P - Nutrients (2015)

Clostridium population changes after three months of age in the different groups of study.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4663570&req=5

nutrients-07-05442-f002: Clostridium population changes after three months of age in the different groups of study.
Mentions: Although Clostridium showed low quantities in all the groups, the most evident differences were between those groups fed with breast milk or formula added with fructans than those fed with formula without fructans (Figure 2). In fact, Clostridium population in those babies fed with formula alone was 57 times higher than those of reference group or groups containing fructans in the formula. In the group fed with formula + Probiotic, Clostridium population was 15 times higher than in the others. Between reference group (breast milk feeding) and groups fed with any of the tested fructans, the relative abundance of Clostridium was almost the same.

Bottom Line: The importance of prebiotics consumption is increasing all over the world due to their beneficial effects on health.Recently, the safety in humans of two fructans obtained from Agave tequilana (Metlin(®) and Metlos(®)) was demonstrated.Our results support the efficacy of Metlin(®) and Metlos(®) as prebiotics in humans, and stand the bases to recommend their consumption.

View Article: PubMed Central - PubMed

Affiliation: Laboratorio de Bioquímica-Genética, Instituto Nacional de Pediatría, Mexico City 04530, México. glv_1999@yahoo.com.

ABSTRACT

Background: The importance of prebiotics consumption is increasing all over the world due to their beneficial effects on health. Production of better prebiotics from endemic plants raises possibilities to enhance nutritional effects in vulnerable population groups. Fructans derived from Agave Plant have demonstrated their safety and efficacy as prebiotics in animal models. Recently, the safety in humans of two fructans obtained from Agave tequilana (Metlin(®) and Metlos(®)) was demonstrated.

Methods: This study aimed to demonstrate the efficacy as prebiotics of Metlin(®) and Metlos(®) in newborns of a randomized, double blind, controlled trial with a pilot study design. Biological samples were taken at 20 ± 7 days, and three months of age from healthy babies. Outcomes of efficacy include impact on immune response, serum ferritin, C-reactive protein, bone metabolism, and gut bacteria changes.

Results: There were differences statistically significant for the groups of infants fed only with infant formula and with formula enriched with Metlin(®) and Metlos(®).

Conclusions: Our results support the efficacy of Metlin(®) and Metlos(®) as prebiotics in humans, and stand the bases to recommend their consumption.

Trial registration: ClinicalTrials.gov, NCT 01251783.

Show MeSH
Related in: MedlinePlus