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Effects of Fructans from Mexican Agave in Newborns Fed with Infant Formula: A Randomized Controlled Trial.

López-Velázquez G, Parra-Ortiz M, Mora Ide L, García-Torres I, Enríquez-Flores S, Alcántara-Ortigoza MA, Angel AG, Velázquez-Aragón J, Ortiz-Hernández R, Cruz-Rubio JM, Villa-Barragán P, Jiménez-Gutiérrez C, Gutiérrez-Castrellón P - Nutrients (2015)

Bottom Line: The importance of prebiotics consumption is increasing all over the world due to their beneficial effects on health.Recently, the safety in humans of two fructans obtained from Agave tequilana (Metlin(®) and Metlos(®)) was demonstrated.Our results support the efficacy of Metlin(®) and Metlos(®) as prebiotics in humans, and stand the bases to recommend their consumption.

View Article: PubMed Central - PubMed

Affiliation: Laboratorio de Bioquímica-Genética, Instituto Nacional de Pediatría, Mexico City 04530, México. glv_1999@yahoo.com.

ABSTRACT

Background: The importance of prebiotics consumption is increasing all over the world due to their beneficial effects on health. Production of better prebiotics from endemic plants raises possibilities to enhance nutritional effects in vulnerable population groups. Fructans derived from Agave Plant have demonstrated their safety and efficacy as prebiotics in animal models. Recently, the safety in humans of two fructans obtained from Agave tequilana (Metlin(®) and Metlos(®)) was demonstrated.

Methods: This study aimed to demonstrate the efficacy as prebiotics of Metlin(®) and Metlos(®) in newborns of a randomized, double blind, controlled trial with a pilot study design. Biological samples were taken at 20 ± 7 days, and three months of age from healthy babies. Outcomes of efficacy include impact on immune response, serum ferritin, C-reactive protein, bone metabolism, and gut bacteria changes.

Results: There were differences statistically significant for the groups of infants fed only with infant formula and with formula enriched with Metlin(®) and Metlos(®).

Conclusions: Our results support the efficacy of Metlin(®) and Metlos(®) as prebiotics in humans, and stand the bases to recommend their consumption.

Trial registration: ClinicalTrials.gov, NCT 01251783.

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Related in: MedlinePlus

Changes in the relative abundance of gut bacteria, according to the kind of feeding after three months of treatment. Data from total counts were taken as 100% to normalize all the other counts. Reference group of breast milk fed (a), and Groups 1, 2, 3, 4, and 5, (b–f), respectively.
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nutrients-07-05442-f001: Changes in the relative abundance of gut bacteria, according to the kind of feeding after three months of treatment. Data from total counts were taken as 100% to normalize all the other counts. Reference group of breast milk fed (a), and Groups 1, 2, 3, 4, and 5, (b–f), respectively.

Mentions: Due to the difficulties on collecting the fecal samples (this was at the time of the pediatric appointment), we were able to collect only 600 samples of feces; 480 samples were of enough quality to isolate DNA and only 300 were from patients who completed the first and the second sampling. From the latter, 148 samples were subjected to real-time PCR. Figure 1 depicts the changes observed among six different groups of bacteria from the data at baseline and three months later for all the groups of study along the clinical trial.


Effects of Fructans from Mexican Agave in Newborns Fed with Infant Formula: A Randomized Controlled Trial.

López-Velázquez G, Parra-Ortiz M, Mora Ide L, García-Torres I, Enríquez-Flores S, Alcántara-Ortigoza MA, Angel AG, Velázquez-Aragón J, Ortiz-Hernández R, Cruz-Rubio JM, Villa-Barragán P, Jiménez-Gutiérrez C, Gutiérrez-Castrellón P - Nutrients (2015)

Changes in the relative abundance of gut bacteria, according to the kind of feeding after three months of treatment. Data from total counts were taken as 100% to normalize all the other counts. Reference group of breast milk fed (a), and Groups 1, 2, 3, 4, and 5, (b–f), respectively.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4663570&req=5

nutrients-07-05442-f001: Changes in the relative abundance of gut bacteria, according to the kind of feeding after three months of treatment. Data from total counts were taken as 100% to normalize all the other counts. Reference group of breast milk fed (a), and Groups 1, 2, 3, 4, and 5, (b–f), respectively.
Mentions: Due to the difficulties on collecting the fecal samples (this was at the time of the pediatric appointment), we were able to collect only 600 samples of feces; 480 samples were of enough quality to isolate DNA and only 300 were from patients who completed the first and the second sampling. From the latter, 148 samples were subjected to real-time PCR. Figure 1 depicts the changes observed among six different groups of bacteria from the data at baseline and three months later for all the groups of study along the clinical trial.

Bottom Line: The importance of prebiotics consumption is increasing all over the world due to their beneficial effects on health.Recently, the safety in humans of two fructans obtained from Agave tequilana (Metlin(®) and Metlos(®)) was demonstrated.Our results support the efficacy of Metlin(®) and Metlos(®) as prebiotics in humans, and stand the bases to recommend their consumption.

View Article: PubMed Central - PubMed

Affiliation: Laboratorio de Bioquímica-Genética, Instituto Nacional de Pediatría, Mexico City 04530, México. glv_1999@yahoo.com.

ABSTRACT

Background: The importance of prebiotics consumption is increasing all over the world due to their beneficial effects on health. Production of better prebiotics from endemic plants raises possibilities to enhance nutritional effects in vulnerable population groups. Fructans derived from Agave Plant have demonstrated their safety and efficacy as prebiotics in animal models. Recently, the safety in humans of two fructans obtained from Agave tequilana (Metlin(®) and Metlos(®)) was demonstrated.

Methods: This study aimed to demonstrate the efficacy as prebiotics of Metlin(®) and Metlos(®) in newborns of a randomized, double blind, controlled trial with a pilot study design. Biological samples were taken at 20 ± 7 days, and three months of age from healthy babies. Outcomes of efficacy include impact on immune response, serum ferritin, C-reactive protein, bone metabolism, and gut bacteria changes.

Results: There were differences statistically significant for the groups of infants fed only with infant formula and with formula enriched with Metlin(®) and Metlos(®).

Conclusions: Our results support the efficacy of Metlin(®) and Metlos(®) as prebiotics in humans, and stand the bases to recommend their consumption.

Trial registration: ClinicalTrials.gov, NCT 01251783.

Show MeSH
Related in: MedlinePlus