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Association between Dietary Vitamin A Intake and the Risk of Glioma: Evidence from a Meta-analysis.

Lv W, Zhong X, Xu L, Han W - Nutrients (2015)

Bottom Line: Egger's test was used to assess the small-study effect.Egger's test did not find any publication bias.In conclusion, our study indicated that higher category of dietary vitamin A intake could reduce the glioma risk.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Neurology, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou 310016, China. wenlv123@yeah.net.

ABSTRACT
The results from epidemiological studies between dietary vitamin A intake and glioma risk is not consistent. Thus, a meta-analysis was conducted to confirm the exact relationship between them. PubMed and Web of Knowledge were used to search the relevant articles up to May 2015. Pooled relative risk (RR) with 95% confidence interval (CI)was calculated using random-effect model. Egger's test was used to assess the small-study effect. At the end, seven articles with eight case-control studies involving 1841 glioma cases and 4123 participants were included. Our study indicated that highest category of dietary vitamin A intake was significantly associated with reduced risk of glioma (RR = 0.80, 95% CI = 0.62-0.98, p = 0.014, I² = 54.9%). Egger's test did not find any publication bias. In conclusion, our study indicated that higher category of dietary vitamin A intake could reduce the glioma risk. However, we could not do a dose-response analysis for vitamin A intake with glioma risk due to the limited data in each reported individual article. Due to this limitation, further studies with detailed dose, cases and person-years for each category is wanted to assess this dose-response association.

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Related in: MedlinePlus

Analysis of influence of individual study on the association between vitamin A intake and glioma risk. Open circle indicates the pooled relative risk, given named study is omitted. Horizontal lines represent the 95% CI.
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nutrients-07-05438-f003: Analysis of influence of individual study on the association between vitamin A intake and glioma risk. Open circle indicates the pooled relative risk, given named study is omitted. Horizontal lines represent the 95% CI.

Mentions: Influence analysis showed that the pooled RR did not lie out of the 95% CI when we removed one individual study at a time (Figure 3). There is no publication bias found by Egger’s regression asymmetry test (p = 0.564).


Association between Dietary Vitamin A Intake and the Risk of Glioma: Evidence from a Meta-analysis.

Lv W, Zhong X, Xu L, Han W - Nutrients (2015)

Analysis of influence of individual study on the association between vitamin A intake and glioma risk. Open circle indicates the pooled relative risk, given named study is omitted. Horizontal lines represent the 95% CI.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4663566&req=5

nutrients-07-05438-f003: Analysis of influence of individual study on the association between vitamin A intake and glioma risk. Open circle indicates the pooled relative risk, given named study is omitted. Horizontal lines represent the 95% CI.
Mentions: Influence analysis showed that the pooled RR did not lie out of the 95% CI when we removed one individual study at a time (Figure 3). There is no publication bias found by Egger’s regression asymmetry test (p = 0.564).

Bottom Line: Egger's test was used to assess the small-study effect.Egger's test did not find any publication bias.In conclusion, our study indicated that higher category of dietary vitamin A intake could reduce the glioma risk.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Neurology, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou 310016, China. wenlv123@yeah.net.

ABSTRACT
The results from epidemiological studies between dietary vitamin A intake and glioma risk is not consistent. Thus, a meta-analysis was conducted to confirm the exact relationship between them. PubMed and Web of Knowledge were used to search the relevant articles up to May 2015. Pooled relative risk (RR) with 95% confidence interval (CI)was calculated using random-effect model. Egger's test was used to assess the small-study effect. At the end, seven articles with eight case-control studies involving 1841 glioma cases and 4123 participants were included. Our study indicated that highest category of dietary vitamin A intake was significantly associated with reduced risk of glioma (RR = 0.80, 95% CI = 0.62-0.98, p = 0.014, I² = 54.9%). Egger's test did not find any publication bias. In conclusion, our study indicated that higher category of dietary vitamin A intake could reduce the glioma risk. However, we could not do a dose-response analysis for vitamin A intake with glioma risk due to the limited data in each reported individual article. Due to this limitation, further studies with detailed dose, cases and person-years for each category is wanted to assess this dose-response association.

Show MeSH
Related in: MedlinePlus