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Association between Dietary Vitamin A Intake and the Risk of Glioma: Evidence from a Meta-analysis.

Lv W, Zhong X, Xu L, Han W - Nutrients (2015)

Bottom Line: Egger's test was used to assess the small-study effect.Egger's test did not find any publication bias.In conclusion, our study indicated that higher category of dietary vitamin A intake could reduce the glioma risk.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Neurology, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou 310016, China. wenlv123@yeah.net.

ABSTRACT
The results from epidemiological studies between dietary vitamin A intake and glioma risk is not consistent. Thus, a meta-analysis was conducted to confirm the exact relationship between them. PubMed and Web of Knowledge were used to search the relevant articles up to May 2015. Pooled relative risk (RR) with 95% confidence interval (CI)was calculated using random-effect model. Egger's test was used to assess the small-study effect. At the end, seven articles with eight case-control studies involving 1841 glioma cases and 4123 participants were included. Our study indicated that highest category of dietary vitamin A intake was significantly associated with reduced risk of glioma (RR = 0.80, 95% CI = 0.62-0.98, p = 0.014, I² = 54.9%). Egger's test did not find any publication bias. In conclusion, our study indicated that higher category of dietary vitamin A intake could reduce the glioma risk. However, we could not do a dose-response analysis for vitamin A intake with glioma risk due to the limited data in each reported individual article. Due to this limitation, further studies with detailed dose, cases and person-years for each category is wanted to assess this dose-response association.

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The forest plot between highest versus lowest categories of vitamin A intake and glioma risk.
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nutrients-07-05438-f002: The forest plot between highest versus lowest categories of vitamin A intake and glioma risk.

Mentions: Data from seven articles with eight studies involving 1841 glioma cases were included in this study. Two studies reported that higher vitamin A intake could reduce the risk of glioma, while five studies found a negative association between them. However, there is one study found an increased risk of glioma with higher category of vitamin A intake. Results from our study suggested that highest category of dietary vitamin A intake versus lowest category could reduce the glioma risk (RR = 0.80, 95% CI = 0.62–0.98, p = 0.014, I2 = 54.9%) (Figure 2).


Association between Dietary Vitamin A Intake and the Risk of Glioma: Evidence from a Meta-analysis.

Lv W, Zhong X, Xu L, Han W - Nutrients (2015)

The forest plot between highest versus lowest categories of vitamin A intake and glioma risk.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4663566&req=5

nutrients-07-05438-f002: The forest plot between highest versus lowest categories of vitamin A intake and glioma risk.
Mentions: Data from seven articles with eight studies involving 1841 glioma cases were included in this study. Two studies reported that higher vitamin A intake could reduce the risk of glioma, while five studies found a negative association between them. However, there is one study found an increased risk of glioma with higher category of vitamin A intake. Results from our study suggested that highest category of dietary vitamin A intake versus lowest category could reduce the glioma risk (RR = 0.80, 95% CI = 0.62–0.98, p = 0.014, I2 = 54.9%) (Figure 2).

Bottom Line: Egger's test was used to assess the small-study effect.Egger's test did not find any publication bias.In conclusion, our study indicated that higher category of dietary vitamin A intake could reduce the glioma risk.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Neurology, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou 310016, China. wenlv123@yeah.net.

ABSTRACT
The results from epidemiological studies between dietary vitamin A intake and glioma risk is not consistent. Thus, a meta-analysis was conducted to confirm the exact relationship between them. PubMed and Web of Knowledge were used to search the relevant articles up to May 2015. Pooled relative risk (RR) with 95% confidence interval (CI)was calculated using random-effect model. Egger's test was used to assess the small-study effect. At the end, seven articles with eight case-control studies involving 1841 glioma cases and 4123 participants were included. Our study indicated that highest category of dietary vitamin A intake was significantly associated with reduced risk of glioma (RR = 0.80, 95% CI = 0.62-0.98, p = 0.014, I² = 54.9%). Egger's test did not find any publication bias. In conclusion, our study indicated that higher category of dietary vitamin A intake could reduce the glioma risk. However, we could not do a dose-response analysis for vitamin A intake with glioma risk due to the limited data in each reported individual article. Due to this limitation, further studies with detailed dose, cases and person-years for each category is wanted to assess this dose-response association.

Show MeSH
Related in: MedlinePlus