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Marine Drugs Regulating Apoptosis Induced by Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL).

Elmallah MI, Micheau O - Mar Drugs (2015)

Bottom Line: Marine biomass diversity is a tremendous source of potential anticancer compounds.Its selectivity for cancer cells has attracted much attention in oncology.This review aims at discussing the main mechanisms by which TRAIL signaling is regulated and presenting how marine bioactive compounds have been found, so far, to overcome TRAIL resistance in tumor cells.

View Article: PubMed Central - PubMed

Affiliation: Department of Chemistry, Faculty of Science, Helwan University, Ain Helwan, Cairo 11790, Egypt. mohamed_almallah@science.helwan.edu.eg.

ABSTRACT
Marine biomass diversity is a tremendous source of potential anticancer compounds. Several natural marine products have been described to restore tumor cell sensitivity to TNF-related apoptosis inducing ligand (TRAIL)-induced cell death. TRAIL is involved during tumor immune surveillance. Its selectivity for cancer cells has attracted much attention in oncology. This review aims at discussing the main mechanisms by which TRAIL signaling is regulated and presenting how marine bioactive compounds have been found, so far, to overcome TRAIL resistance in tumor cells.

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Selected marine-derived natural products with potent TRAIL-resistance overcoming activity.
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marinedrugs-13-06884-f004: Selected marine-derived natural products with potent TRAIL-resistance overcoming activity.

Mentions: Restoration or enhancement of apoptosis induced by TRAIL in resistant cancer is a prerequisite for the use of TRAIL in the clinic [167,168]. Exploration of natural products derived from terrestrial plants and marine fauna or flora pharmacopeia is, thus, likely to provide potent and selective TRAIL-sensitizing compounds [169,170,171,172]. The marine environment is enriched with a wide variety of living organisms, including bacteria, actinobacteria, sponges, fungi, microalgae, soft corals, seaweeds and flowering plants, such as mangroves, which have been reported as unexplored source for the discovery of potential anti-cancer compounds [173], as well as anti-bacterial, anti-fungal, antioxidants, or immunomodulatory activities [173,174,175]. This biomass diversity is considered as an unlimited source of structurally novel bioactive compounds, whose structural novelties, as well as variation in chemical features, confer to these organisms unique properties allowing them to survive in extreme marine environmental conditions, such as high salinity, temperature, or pressure [176,177,178]. Several natural marine products have been reported for their potent TRAIL-sensitizing effect in various TRAIL-resistant cancer cell lines (Table 1 and Figure 4) [171,179].


Marine Drugs Regulating Apoptosis Induced by Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL).

Elmallah MI, Micheau O - Mar Drugs (2015)

Selected marine-derived natural products with potent TRAIL-resistance overcoming activity.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4663558&req=5

marinedrugs-13-06884-f004: Selected marine-derived natural products with potent TRAIL-resistance overcoming activity.
Mentions: Restoration or enhancement of apoptosis induced by TRAIL in resistant cancer is a prerequisite for the use of TRAIL in the clinic [167,168]. Exploration of natural products derived from terrestrial plants and marine fauna or flora pharmacopeia is, thus, likely to provide potent and selective TRAIL-sensitizing compounds [169,170,171,172]. The marine environment is enriched with a wide variety of living organisms, including bacteria, actinobacteria, sponges, fungi, microalgae, soft corals, seaweeds and flowering plants, such as mangroves, which have been reported as unexplored source for the discovery of potential anti-cancer compounds [173], as well as anti-bacterial, anti-fungal, antioxidants, or immunomodulatory activities [173,174,175]. This biomass diversity is considered as an unlimited source of structurally novel bioactive compounds, whose structural novelties, as well as variation in chemical features, confer to these organisms unique properties allowing them to survive in extreme marine environmental conditions, such as high salinity, temperature, or pressure [176,177,178]. Several natural marine products have been reported for their potent TRAIL-sensitizing effect in various TRAIL-resistant cancer cell lines (Table 1 and Figure 4) [171,179].

Bottom Line: Marine biomass diversity is a tremendous source of potential anticancer compounds.Its selectivity for cancer cells has attracted much attention in oncology.This review aims at discussing the main mechanisms by which TRAIL signaling is regulated and presenting how marine bioactive compounds have been found, so far, to overcome TRAIL resistance in tumor cells.

View Article: PubMed Central - PubMed

Affiliation: Department of Chemistry, Faculty of Science, Helwan University, Ain Helwan, Cairo 11790, Egypt. mohamed_almallah@science.helwan.edu.eg.

ABSTRACT
Marine biomass diversity is a tremendous source of potential anticancer compounds. Several natural marine products have been described to restore tumor cell sensitivity to TNF-related apoptosis inducing ligand (TRAIL)-induced cell death. TRAIL is involved during tumor immune surveillance. Its selectivity for cancer cells has attracted much attention in oncology. This review aims at discussing the main mechanisms by which TRAIL signaling is regulated and presenting how marine bioactive compounds have been found, so far, to overcome TRAIL resistance in tumor cells.

Show MeSH
Related in: MedlinePlus