Chemical structures of some phlorotannins (phloroglucin

Seaweeds as Preventive Agents for Cardiovascular Diseases: From Nutrients to Functional Foods. Cardoso SM, Pereira OR, Seca AM, Pinto DC, Silva AM - Mar Drugs (2015) Bottom Line: Being naturally enriched in key nutrients and in various health-promoting compounds, seaweeds represent promising candidates for the design of functional foods.Soluble dietary fibers, peptides, phlorotannins, lipids and minerals are macroalgae's major compounds that can hold potential in high-value food products derived from macroalgae, including those directed to the cardiovascular-health promotion.At last, the review also describes several products that have been formulated with the use of whole macroalgae or extracts, along with their claimed cardiovascular-associated benefits. View Article: PubMed Central - PubMed Affiliation: Department of Chemistry & QOPNA, University of Aveiro, Aveiro 3810-193, Portugal. susanacardoso@ua.pt. ABSTRACT Being naturally enriched in key nutrients and in various health-promoting compounds, seaweeds represent promising candidates for the design of functional foods. Soluble dietary fibers, peptides, phlorotannins, lipids and minerals are macroalgae's major compounds that can hold potential in high-value food products derived from macroalgae, including those directed to the cardiovascular-health promotion. This manuscript revises available reported data focusing the role of diet supplementation of macroalgae, or extracts enriched in bioactive compounds from macroalgae origin, in targeting modifiable markers of cardiovascular diseases (CVDs), like dyslipidemia, oxidative stress, vascular inflammation, hypertension, hypercoagulability and activation of the sympathetic and renin-angiotensin systems, among others. At last, the review also describes several products that have been formulated with the use of whole macroalgae or extracts, along with their claimed cardiovascular-associated benefits. Show MeSH Major Cardiovascular Diseases/prevention & control* Dietary Supplements* Seaweed/chemistry* Minor Animals Functional Food Humans Related in: MedlinePlus	© Copyright Policy Related In: Results - Collection License Show All Figures getmorefigures.php?uid=PMC4663556&req=5 marinedrugs-13-06838-f001: Chemical structures of some phlorotannins (phloroglucinol, eckol, phlorofucofuroeckol-A and dieckol) and fucoxanthin. Mentions: Phlorotannins are phenolic compounds exclusive to brown algae that consist of dehydro-oligomers or dehydro-polymers of phloroglucinol (Figure 1), occurring in a wide range of molecular arrangements including variations in the nature of the structural linkages between phloroglucinol units (aryl-aryl or diaryl ether bonds) and the number of hydroxyl groups [25,26]. These phenolic compounds are known to accumulate mainly in the cell cytoplasm in specialized secretion vesicles named physode, representing up to 25% of their DW [26]. Although studies focusing on the characterization and bioactivity of individual phlorotannins are still very limited, several of these compounds have already been isolated and characterized (e.g., phloroglucinol, eckol, phlorofucofuroeckol A and dieckol, see Figure 1) and claimed to provide a wide range of biological activities, including potent antioxidant effects [27].

Seaweeds as Preventive Agents for Cardiovascular Diseases: From Nutrients to Functional Foods.

Cardoso SM, Pereira OR, Seca AM, Pinto DC, Silva AM - Mar Drugs (2015)

Bottom Line: Being naturally enriched in key nutrients and in various health-promoting compounds, seaweeds represent promising candidates for the design of functional foods.Soluble dietary fibers, peptides, phlorotannins, lipids and minerals are macroalgae's major compounds that can hold potential in high-value food products derived from macroalgae, including those directed to the cardiovascular-health promotion.At last, the review also describes several products that have been formulated with the use of whole macroalgae or extracts, along with their claimed cardiovascular-associated benefits.

View Article: PubMed Central - PubMed

Affiliation: Department of Chemistry & QOPNA, University of Aveiro, Aveiro 3810-193, Portugal. susanacardoso@ua.pt.

ABSTRACT

Being naturally enriched in key nutrients and in various health-promoting compounds, seaweeds represent promising candidates for the design of functional foods. Soluble dietary fibers, peptides, phlorotannins, lipids and minerals are macroalgae's major compounds that can hold potential in high-value food products derived from macroalgae, including those directed to the cardiovascular-health promotion. This manuscript revises available reported data focusing the role of diet supplementation of macroalgae, or extracts enriched in bioactive compounds from macroalgae origin, in targeting modifiable markers of cardiovascular diseases (CVDs), like dyslipidemia, oxidative stress, vascular inflammation, hypertension, hypercoagulability and activation of the sympathetic and renin-angiotensin systems, among others. At last, the review also describes several products that have been formulated with the use of whole macroalgae or extracts, along with their claimed cardiovascular-associated benefits.

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Related in: MedlinePlus

Chemical structures of some phlorotannins (phloroglucinol, eckol, phlorofucofuroeckol-A and dieckol) and fucoxanthin.

Related In: Results - Collection

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marinedrugs-13-06838-f001: Chemical structures of some phlorotannins (phloroglucinol, eckol, phlorofucofuroeckol-A and dieckol) and fucoxanthin.

Mentions: Phlorotannins are phenolic compounds exclusive to brown algae that consist of dehydro-oligomers or dehydro-polymers of phloroglucinol (Figure 1), occurring in a wide range of molecular arrangements including variations in the nature of the structural linkages between phloroglucinol units (aryl-aryl or diaryl ether bonds) and the number of hydroxyl groups [25,26]. These phenolic compounds are known to accumulate mainly in the cell cytoplasm in specialized secretion vesicles named physode, representing up to 25% of their DW [26]. Although studies focusing on the characterization and bioactivity of individual phlorotannins are still very limited, several of these compounds have already been isolated and characterized (e.g., phloroglucinol, eckol, phlorofucofuroeckol A and dieckol, see Figure 1) and claimed to provide a wide range of biological activities, including potent antioxidant effects [27].