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Post-traumatic stress disorder.

Bisson JI, Cosgrove S, Lewis C, Robert NP - BMJ (2015)

View Article: PubMed Central - PubMed

Affiliation: Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, UK BissonJI@cardiff.ac.uk.

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PTSD is a mental disorder that may develop after exposure to exceptionally threatening or horrifying events... PTSD can occur after a single traumatic event or from prolonged exposure to trauma, such as sexual abuse in childhood... Effect sizes with drug treatment are similar to those observed from use of antidepressants for depression compared with placebo... A recent systematic review and meta-analysis found statistically significant evidence (when at least two RCTs were available) of reduction in severity of PTSD symptoms for four drugs (fluoxetine, paroxetine, sertraline, and venlafaxine) versus placebo... In single RCTs, amitriptyline, GR205171 (a neurokinin-1 antagonist), mirtazapine, and phenelzine have shown superiority over placebo in reducing the symptoms of PTSD... In an RCT the α 1 adrenoceptor antagonist prazosin was found to reduce nightmares in veterans with PTSD, and a further RCT in veterans showed reduction in overall symptom severity... Some evidence suggests that trauma focused CBT can be effective with concomitant interventions to stabilise drug or alcohol use, but treatment effects are not as large as for PTSD in the absence of drug or alcohol misuse... Several experimental studies provide hope that better or alternative ways to prevent and treat PTSD are on the way... Simple visuospatial tasks such as playing a computer game shortly after a traumatic experience reduce re-experiencing... For established PTSD, interest in using drugs to augment psychological therapy is increasing... The results of a recent RCT of the psychedelic 3,4-methylenedioxymethylamphetamine with psychotherapy for treatment resistant PTSD have been promising.

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Examples of the many different trajectories of PTSD symptoms after exposure to trauma
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fig1: Examples of the many different trajectories of PTSD symptoms after exposure to trauma


Post-traumatic stress disorder.

Bisson JI, Cosgrove S, Lewis C, Robert NP - BMJ (2015)

Examples of the many different trajectories of PTSD symptoms after exposure to trauma
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4663500&req=5

fig1: Examples of the many different trajectories of PTSD symptoms after exposure to trauma

View Article: PubMed Central - PubMed

Affiliation: Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, UK BissonJI@cardiff.ac.uk.

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

PTSD is a mental disorder that may develop after exposure to exceptionally threatening or horrifying events... PTSD can occur after a single traumatic event or from prolonged exposure to trauma, such as sexual abuse in childhood... Effect sizes with drug treatment are similar to those observed from use of antidepressants for depression compared with placebo... A recent systematic review and meta-analysis found statistically significant evidence (when at least two RCTs were available) of reduction in severity of PTSD symptoms for four drugs (fluoxetine, paroxetine, sertraline, and venlafaxine) versus placebo... In single RCTs, amitriptyline, GR205171 (a neurokinin-1 antagonist), mirtazapine, and phenelzine have shown superiority over placebo in reducing the symptoms of PTSD... In an RCT the α 1 adrenoceptor antagonist prazosin was found to reduce nightmares in veterans with PTSD, and a further RCT in veterans showed reduction in overall symptom severity... Some evidence suggests that trauma focused CBT can be effective with concomitant interventions to stabilise drug or alcohol use, but treatment effects are not as large as for PTSD in the absence of drug or alcohol misuse... Several experimental studies provide hope that better or alternative ways to prevent and treat PTSD are on the way... Simple visuospatial tasks such as playing a computer game shortly after a traumatic experience reduce re-experiencing... For established PTSD, interest in using drugs to augment psychological therapy is increasing... The results of a recent RCT of the psychedelic 3,4-methylenedioxymethylamphetamine with psychotherapy for treatment resistant PTSD have been promising.

Show MeSH
Related in: MedlinePlus