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Predictive value of autoantibodies from anti-CCP2, anti-MCV and anti-human citrullinated fibrinogen tests, in early rheumatoid arthritis patients with rapid radiographic progression at 1 year: results from the ESPOIR cohort.

Degboé Y, Constantin A, Nigon D, Tobon G, Cornillet M, Schaeverbeke T, Chiocchia G, Nicaise-Roland P, Nogueira L, Serre G, Cantagrel A, Ruyssen-Witrand A - RMD Open (2015)

Bottom Line: High ACPA titres were associated with 1 year RRP, whatever the test was, and with similar ORs.Low+ anti-MCV titres were not associated with 1-year RRP, whereas low+ anti-CCP2 titres (p=0.0226) and low+ AhFibA titres (p=0.0332) were significantly associated.In multivariate analysis, 1 year RRP was associated with anti-CCP2 positivity (p<0.0001), AhFibA positivity (p<0.0001) and high anti-MCV titres (p<0.0001).

View Article: PubMed Central - PubMed

Affiliation: Rheumatology Center, Purpan University Hospital , Toulouse , France ; UMR 1043, INSERM, CPTP , Toulouse , France.

ABSTRACT

Objectives: We compared the ability of antibodies against cyclic citrullinated peptides (anti-CCP2), against mutated citrullinated vimentin (anti-MCV) and against citrullinated fibrinogen (AhFibA) to predict 1 year rapid radiographic progression (RRP; total Sharp score variation ≥5 points), in early rheumatoid arthritis (RA).

Methods: We analysed 566 patients from the ESPOIR cohort with early RA fulfilling the 2010 American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) criteria at year 1. We assayed the 3 anticitrullinated peptide antibodies (ACPA) tests on baseline sera. We compared the performance of these 3 ACPA tests to predict first-year RRP, by comparing areas under the receiver operating characteristic curves (ROCs). We assessed the 1 year RRP risk by ACPA titres. We used a logistic multivariate regression to analyse RRP risk in terms either of ACPA positivity or titre: high (>3 times the N cut-off) and low (1 to 3N).

Results: 145 patients displayed RRP. Areas under the ROCs were similar (0.60) for the 3 tests. High ACPA titres were associated with 1 year RRP, whatever the test was, and with similar ORs. Low+ anti-MCV titres were not associated with 1-year RRP, whereas low+ anti-CCP2 titres (p=0.0226) and low+ AhFibA titres (p=0.0332) were significantly associated. In multivariate analysis, 1 year RRP was associated with anti-CCP2 positivity (p<0.0001), AhFibA positivity (p<0.0001) and high anti-MCV titres (p<0.0001).

Conclusions: Anti-CCP2 antibodies and AhFibA were predictive of 1 year RRP in early RA whatever their titre was, whereas only high anti-MCV antibody titres were predictive, potentially making them more discriminant to predict 1 year RRP risk.

No MeSH data available.


Related in: MedlinePlus

Receiver operating characteristic (ROC) curves: rapid radiographic progression prognosis by anticyclic citrullinated peptides generation 2 antibodies (anti-CCP2), antimutated citrullinated vimentine antibodies (anti-MCV) and antihuman citrullinated fibrinogen antibodies (AhFibA) tests. ROC curves built on the ability of each test (for anti-CCP2, anti-MCV and AhFibA) to predict 1-year rapid radiographic progression. Area under the curve values are expressed as continuous variables.
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RMDOPEN2015000180F1: Receiver operating characteristic (ROC) curves: rapid radiographic progression prognosis by anticyclic citrullinated peptides generation 2 antibodies (anti-CCP2), antimutated citrullinated vimentine antibodies (anti-MCV) and antihuman citrullinated fibrinogen antibodies (AhFibA) tests. ROC curves built on the ability of each test (for anti-CCP2, anti-MCV and AhFibA) to predict 1-year rapid radiographic progression. Area under the curve values are expressed as continuous variables.

Mentions: The AUCs for anti-CCP2, anti-MCV and AhFibA antibodies were similar, and matched with modest performance: respectively, 0.601 (95% CI 0.550 to 0.651), 0.607 (95% CI 0.555 to 0.659) and 0.599 (95% CI 0.547 to 0.651). No differences were found among the tests (p=0.87; figure 1).


Predictive value of autoantibodies from anti-CCP2, anti-MCV and anti-human citrullinated fibrinogen tests, in early rheumatoid arthritis patients with rapid radiographic progression at 1 year: results from the ESPOIR cohort.

Degboé Y, Constantin A, Nigon D, Tobon G, Cornillet M, Schaeverbeke T, Chiocchia G, Nicaise-Roland P, Nogueira L, Serre G, Cantagrel A, Ruyssen-Witrand A - RMD Open (2015)

Receiver operating characteristic (ROC) curves: rapid radiographic progression prognosis by anticyclic citrullinated peptides generation 2 antibodies (anti-CCP2), antimutated citrullinated vimentine antibodies (anti-MCV) and antihuman citrullinated fibrinogen antibodies (AhFibA) tests. ROC curves built on the ability of each test (for anti-CCP2, anti-MCV and AhFibA) to predict 1-year rapid radiographic progression. Area under the curve values are expressed as continuous variables.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4663455&req=5

RMDOPEN2015000180F1: Receiver operating characteristic (ROC) curves: rapid radiographic progression prognosis by anticyclic citrullinated peptides generation 2 antibodies (anti-CCP2), antimutated citrullinated vimentine antibodies (anti-MCV) and antihuman citrullinated fibrinogen antibodies (AhFibA) tests. ROC curves built on the ability of each test (for anti-CCP2, anti-MCV and AhFibA) to predict 1-year rapid radiographic progression. Area under the curve values are expressed as continuous variables.
Mentions: The AUCs for anti-CCP2, anti-MCV and AhFibA antibodies were similar, and matched with modest performance: respectively, 0.601 (95% CI 0.550 to 0.651), 0.607 (95% CI 0.555 to 0.659) and 0.599 (95% CI 0.547 to 0.651). No differences were found among the tests (p=0.87; figure 1).

Bottom Line: High ACPA titres were associated with 1 year RRP, whatever the test was, and with similar ORs.Low+ anti-MCV titres were not associated with 1-year RRP, whereas low+ anti-CCP2 titres (p=0.0226) and low+ AhFibA titres (p=0.0332) were significantly associated.In multivariate analysis, 1 year RRP was associated with anti-CCP2 positivity (p<0.0001), AhFibA positivity (p<0.0001) and high anti-MCV titres (p<0.0001).

View Article: PubMed Central - PubMed

Affiliation: Rheumatology Center, Purpan University Hospital , Toulouse , France ; UMR 1043, INSERM, CPTP , Toulouse , France.

ABSTRACT

Objectives: We compared the ability of antibodies against cyclic citrullinated peptides (anti-CCP2), against mutated citrullinated vimentin (anti-MCV) and against citrullinated fibrinogen (AhFibA) to predict 1 year rapid radiographic progression (RRP; total Sharp score variation ≥5 points), in early rheumatoid arthritis (RA).

Methods: We analysed 566 patients from the ESPOIR cohort with early RA fulfilling the 2010 American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) criteria at year 1. We assayed the 3 anticitrullinated peptide antibodies (ACPA) tests on baseline sera. We compared the performance of these 3 ACPA tests to predict first-year RRP, by comparing areas under the receiver operating characteristic curves (ROCs). We assessed the 1 year RRP risk by ACPA titres. We used a logistic multivariate regression to analyse RRP risk in terms either of ACPA positivity or titre: high (>3 times the N cut-off) and low (1 to 3N).

Results: 145 patients displayed RRP. Areas under the ROCs were similar (0.60) for the 3 tests. High ACPA titres were associated with 1 year RRP, whatever the test was, and with similar ORs. Low+ anti-MCV titres were not associated with 1-year RRP, whereas low+ anti-CCP2 titres (p=0.0226) and low+ AhFibA titres (p=0.0332) were significantly associated. In multivariate analysis, 1 year RRP was associated with anti-CCP2 positivity (p<0.0001), AhFibA positivity (p<0.0001) and high anti-MCV titres (p<0.0001).

Conclusions: Anti-CCP2 antibodies and AhFibA were predictive of 1 year RRP in early RA whatever their titre was, whereas only high anti-MCV antibody titres were predictive, potentially making them more discriminant to predict 1 year RRP risk.

No MeSH data available.


Related in: MedlinePlus