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Effect of increased water intake on plasma copeptin in patients with chronic kidney disease: results from a pilot randomised controlled trial.

Sontrop JM, Huang SH, Garg AX, Moist L, House AA, Gallo K, Clark WF - BMJ Open (2015)

Bottom Line: Change in plasma copeptin was compared within and between study groups.In the hydration group, median copeptin decreased by 3.6 pmol/L, from 15.0 to 10.8 pmol/L (p=0.005), while remaining stable among controls at 19 pmol/L (p=0.76; p=0.19 for the between-group difference in median change); the between-group difference in mean change was 5.4 pmol/L (95% CI -1.2 to 12.0; p=0.11).This increased water intake caused a significant decrease in plasma copeptin concentration.

View Article: PubMed Central - PubMed

Affiliation: Division of Nephrology, Department of Medicine, London Health Sciences Centre, London, Ontario, Canada Department of Epidemiology & Biostatistics, Western University, London, Ontario, Canada.

No MeSH data available.


Related in: MedlinePlus

Intraindividual change in copeptin between baseline and 6 weeks after randomisation.
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BMJOPEN2015008634F1: Intraindividual change in copeptin between baseline and 6 weeks after randomisation.

Mentions: Change in copeptin between baseline and 6 weeks is shown in table 2 and figure 1. During this time, 24 h urine volume increased by 0.7 L/day in the hydration group (p=0.01) and decreased by 0.3 L/day in the control group (p=0.07); the between-group difference in change was 0.9 L/day (95% CI 0.37 to 1.46; p=0.002). In the hydration group, the median plasma copeptin concentration decreased significantly between baseline and follow-up, from 15.0 to 10.8 pmol/L (p=0.005), while remaining relatively stable among controls, at 19 pmol/L (p=0.76); p=0.19 for the between-group difference in median change. The between-group difference in the mean change was 5.4 pmol/L (95% CI −1.2 to 12.0; p=0.11).


Effect of increased water intake on plasma copeptin in patients with chronic kidney disease: results from a pilot randomised controlled trial.

Sontrop JM, Huang SH, Garg AX, Moist L, House AA, Gallo K, Clark WF - BMJ Open (2015)

Intraindividual change in copeptin between baseline and 6 weeks after randomisation.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4663439&req=5

BMJOPEN2015008634F1: Intraindividual change in copeptin between baseline and 6 weeks after randomisation.
Mentions: Change in copeptin between baseline and 6 weeks is shown in table 2 and figure 1. During this time, 24 h urine volume increased by 0.7 L/day in the hydration group (p=0.01) and decreased by 0.3 L/day in the control group (p=0.07); the between-group difference in change was 0.9 L/day (95% CI 0.37 to 1.46; p=0.002). In the hydration group, the median plasma copeptin concentration decreased significantly between baseline and follow-up, from 15.0 to 10.8 pmol/L (p=0.005), while remaining relatively stable among controls, at 19 pmol/L (p=0.76); p=0.19 for the between-group difference in median change. The between-group difference in the mean change was 5.4 pmol/L (95% CI −1.2 to 12.0; p=0.11).

Bottom Line: Change in plasma copeptin was compared within and between study groups.In the hydration group, median copeptin decreased by 3.6 pmol/L, from 15.0 to 10.8 pmol/L (p=0.005), while remaining stable among controls at 19 pmol/L (p=0.76; p=0.19 for the between-group difference in median change); the between-group difference in mean change was 5.4 pmol/L (95% CI -1.2 to 12.0; p=0.11).This increased water intake caused a significant decrease in plasma copeptin concentration.

View Article: PubMed Central - PubMed

Affiliation: Division of Nephrology, Department of Medicine, London Health Sciences Centre, London, Ontario, Canada Department of Epidemiology & Biostatistics, Western University, London, Ontario, Canada.

No MeSH data available.


Related in: MedlinePlus