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Bone mineral density and fracture risk with long-term use of inhaled corticosteroids in patients with asthma: systematic review and meta-analysis.

Loke YK, Gilbert D, Thavarajah M, Blanco P, Wilson AM - BMJ Open (2015)

Bottom Line: Three RCTs and three observational studies in children reported on bone mineral density at the lumbar spine, and our meta-analysis did not show significant reductions with ICS use.Three RCTs and four observational studies in adults reported on ICS use and bone mineral density at the lumbar spine and femur, with no significant reductions found in the meta-analysis compared to control.ICS use for ≥12 months in adults or children with asthma was not significantly associated with harmful effects on fractures or bone mineral density.

View Article: PubMed Central - PubMed

Affiliation: Norwich Medical School, University of East Anglia, Norwich, UK.

No MeSH data available.


Related in: MedlinePlus

BMD in adults, ICS use versus non-use. BMD, bone mineral density; ICS, inhaled corticosteroids; RCT, randomised controlled trial.
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BMJOPEN2015008554F4: BMD in adults, ICS use versus non-use. BMD, bone mineral density; ICS, inhaled corticosteroids; RCT, randomised controlled trial.

Mentions: Three RCTs and four observational studies reported on comparative change in BMD at the lumbar spine in adults (figure 4).16–1824283031 ICS use was not associated with significant reductions in BMD as compared to controls in RCTs (mean difference −0.0019 g/cm2; 95% CI −0.0075 to 0.0038 g/cm2; I2=0%) or observational studies (mean difference −0.0055 g/cm2; 95% CI −0.047 to 0.058 g/cm2; I2=45%).


Bone mineral density and fracture risk with long-term use of inhaled corticosteroids in patients with asthma: systematic review and meta-analysis.

Loke YK, Gilbert D, Thavarajah M, Blanco P, Wilson AM - BMJ Open (2015)

BMD in adults, ICS use versus non-use. BMD, bone mineral density; ICS, inhaled corticosteroids; RCT, randomised controlled trial.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4663435&req=5

BMJOPEN2015008554F4: BMD in adults, ICS use versus non-use. BMD, bone mineral density; ICS, inhaled corticosteroids; RCT, randomised controlled trial.
Mentions: Three RCTs and four observational studies reported on comparative change in BMD at the lumbar spine in adults (figure 4).16–1824283031 ICS use was not associated with significant reductions in BMD as compared to controls in RCTs (mean difference −0.0019 g/cm2; 95% CI −0.0075 to 0.0038 g/cm2; I2=0%) or observational studies (mean difference −0.0055 g/cm2; 95% CI −0.047 to 0.058 g/cm2; I2=45%).

Bottom Line: Three RCTs and three observational studies in children reported on bone mineral density at the lumbar spine, and our meta-analysis did not show significant reductions with ICS use.Three RCTs and four observational studies in adults reported on ICS use and bone mineral density at the lumbar spine and femur, with no significant reductions found in the meta-analysis compared to control.ICS use for ≥12 months in adults or children with asthma was not significantly associated with harmful effects on fractures or bone mineral density.

View Article: PubMed Central - PubMed

Affiliation: Norwich Medical School, University of East Anglia, Norwich, UK.

No MeSH data available.


Related in: MedlinePlus