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Bone mineral density and fracture risk with long-term use of inhaled corticosteroids in patients with asthma: systematic review and meta-analysis.

Loke YK, Gilbert D, Thavarajah M, Blanco P, Wilson AM - BMJ Open (2015)

Bottom Line: Three RCTs and three observational studies in children reported on bone mineral density at the lumbar spine, and our meta-analysis did not show significant reductions with ICS use.Three RCTs and four observational studies in adults reported on ICS use and bone mineral density at the lumbar spine and femur, with no significant reductions found in the meta-analysis compared to control.ICS use for ≥12 months in adults or children with asthma was not significantly associated with harmful effects on fractures or bone mineral density.

View Article: PubMed Central - PubMed

Affiliation: Norwich Medical School, University of East Anglia, Norwich, UK.

No MeSH data available.


Related in: MedlinePlus

Flow diagram of study selection. BMD, bone mineral density; RCT, randomised controlled trial.
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BMJOPEN2015008554F1: Flow diagram of study selection. BMD, bone mineral density; RCT, randomised controlled trial.

Mentions: We screened 1887 potentially relevant articles, and finally included 18 studies in our systematic review (comprising 7 RCTs,14–20and 11 observational studies).21–31 The process of study selection is shown in figure 1.


Bone mineral density and fracture risk with long-term use of inhaled corticosteroids in patients with asthma: systematic review and meta-analysis.

Loke YK, Gilbert D, Thavarajah M, Blanco P, Wilson AM - BMJ Open (2015)

Flow diagram of study selection. BMD, bone mineral density; RCT, randomised controlled trial.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4663435&req=5

BMJOPEN2015008554F1: Flow diagram of study selection. BMD, bone mineral density; RCT, randomised controlled trial.
Mentions: We screened 1887 potentially relevant articles, and finally included 18 studies in our systematic review (comprising 7 RCTs,14–20and 11 observational studies).21–31 The process of study selection is shown in figure 1.

Bottom Line: Three RCTs and three observational studies in children reported on bone mineral density at the lumbar spine, and our meta-analysis did not show significant reductions with ICS use.Three RCTs and four observational studies in adults reported on ICS use and bone mineral density at the lumbar spine and femur, with no significant reductions found in the meta-analysis compared to control.ICS use for ≥12 months in adults or children with asthma was not significantly associated with harmful effects on fractures or bone mineral density.

View Article: PubMed Central - PubMed

Affiliation: Norwich Medical School, University of East Anglia, Norwich, UK.

No MeSH data available.


Related in: MedlinePlus