Memory for gist and detail information in patients with Parkinson's disease.
Bottom Line: Memory deficits have been reported in patients with Parkinson's disease (PD); however, few studies have explicitly addressed the nature of these deficits.Each participant received a gist-based recognition test following the Deese-Roediger-McDermott paradigm, as well as neuropsychological tests and measures of clinical characteristics.Correlation analysis showed that item-specific memory was related to executive functions in normal controls and early-stage patients with PD (H&Y stage: I-II); however, item-specific memory was related to episodic memory, rather than to executive functions, in advanced-stage patients with PD.
Affiliation: Institute of Behavioral Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan.Show MeSH
Related in: MedlinePlus
Mentions: As shown in table 2 and figure 1, after correcting for response bias, the ANOVA revealed a significant group difference in gist memory (F2,64=3.58, p=0.033). Post hoc tests indicated that the advanced-stage PD group had the worst gist memory performance. No significant difference in item-specific memory was found between the three groups. Furthermore, there was a significant group effect (F2,64=6.00, p=0.004) for the corrected target recognition rate (studied–unstudied). At the individual level, there was a significant intra-subject difference in the performance of item-specific memory relative to that of gist memory in the DRM paradigm among early-stage patients with PD (paired t test, t(28)=4.13, p<0.0001) and NCs (t(27)=4.23, p<0.0001).
Affiliation: Institute of Behavioral Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan.