Limits...
Biomarkers of Eating Disorders Using Support Vector Machine Analysis of Structural Neuroimaging Data: Preliminary Results.

Cerasa A, Castiglioni I, Salvatore C, Funaro A, Martino I, Alfano S, Donzuso G, Perrotta P, Gioia MC, Gilardi MC, Quattrone A - Behav Neurol (2015)

Bottom Line: Machine learning allowed individual diagnosis of ED versus HC with an Accuracy ≥ 0.80.Voxel-based pattern recognition analysis demonstrated that voxels influencing the classification Accuracy involved the occipital cortex, the posterior cerebellar lobule, precuneus, sensorimotor/premotor cortices, and the medial prefrontal cortex, all critical regions known to be strongly involved in the pathophysiological mechanisms of ED.Although these findings should be considered preliminary given the small size investigated, SVM analysis highlights the role of well-known brain regions as possible biomarkers to distinguish ED from HC at an individual level, thus encouraging the translational implementation of this new multivariate approach in the clinical practice.

View Article: PubMed Central - PubMed

Affiliation: IBFM-CNR, 88100 Catanzaro, Italy.

ABSTRACT
Presently, there are no valid biomarkers to identify individuals with eating disorders (ED). The aim of this work was to assess the feasibility of a machine learning method for extracting reliable neuroimaging features allowing individual categorization of patients with ED. Support Vector Machine (SVM) technique, combined with a pattern recognition method, was employed utilizing structural magnetic resonance images. Seventeen females with ED (six with diagnosis of anorexia nervosa and 11 with bulimia nervosa) were compared against 17 body mass index-matched healthy controls (HC). Machine learning allowed individual diagnosis of ED versus HC with an Accuracy ≥ 0.80. Voxel-based pattern recognition analysis demonstrated that voxels influencing the classification Accuracy involved the occipital cortex, the posterior cerebellar lobule, precuneus, sensorimotor/premotor cortices, and the medial prefrontal cortex, all critical regions known to be strongly involved in the pathophysiological mechanisms of ED. Although these findings should be considered preliminary given the small size investigated, SVM analysis highlights the role of well-known brain regions as possible biomarkers to distinguish ED from HC at an individual level, thus encouraging the translational implementation of this new multivariate approach in the clinical practice.

Show MeSH

Related in: MedlinePlus

Voxel-based pattern distribution map of brain structural differences between ED patients and healthy controls (sagittal view, threshold = 50%). Voxel-based pattern distribution (normalized to a range between 0 and 1) is expressed according to the color scale and superimposed on a standard stereotactic brain for spatial localization.
© Copyright Policy
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4663371&req=5

fig4: Voxel-based pattern distribution map of brain structural differences between ED patients and healthy controls (sagittal view, threshold = 50%). Voxel-based pattern distribution (normalized to a range between 0 and 1) is expressed according to the color scale and superimposed on a standard stereotactic brain for spatial localization.

Mentions: Figure 4 shows the voxel-based pattern distribution map of brain structural differences between ED patients and HC. The pattern of differences emerged mainly in the occipital cortex and the posterior cerebellar lobule. Moreover, other brain regions involved in regulation of emotional processing known to be damaged in ED patients were detected: precuneus, sensorimotor and premotor cortices as well as the ACC and OFC.


Biomarkers of Eating Disorders Using Support Vector Machine Analysis of Structural Neuroimaging Data: Preliminary Results.

Cerasa A, Castiglioni I, Salvatore C, Funaro A, Martino I, Alfano S, Donzuso G, Perrotta P, Gioia MC, Gilardi MC, Quattrone A - Behav Neurol (2015)

Voxel-based pattern distribution map of brain structural differences between ED patients and healthy controls (sagittal view, threshold = 50%). Voxel-based pattern distribution (normalized to a range between 0 and 1) is expressed according to the color scale and superimposed on a standard stereotactic brain for spatial localization.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4663371&req=5

fig4: Voxel-based pattern distribution map of brain structural differences between ED patients and healthy controls (sagittal view, threshold = 50%). Voxel-based pattern distribution (normalized to a range between 0 and 1) is expressed according to the color scale and superimposed on a standard stereotactic brain for spatial localization.
Mentions: Figure 4 shows the voxel-based pattern distribution map of brain structural differences between ED patients and HC. The pattern of differences emerged mainly in the occipital cortex and the posterior cerebellar lobule. Moreover, other brain regions involved in regulation of emotional processing known to be damaged in ED patients were detected: precuneus, sensorimotor and premotor cortices as well as the ACC and OFC.

Bottom Line: Machine learning allowed individual diagnosis of ED versus HC with an Accuracy ≥ 0.80.Voxel-based pattern recognition analysis demonstrated that voxels influencing the classification Accuracy involved the occipital cortex, the posterior cerebellar lobule, precuneus, sensorimotor/premotor cortices, and the medial prefrontal cortex, all critical regions known to be strongly involved in the pathophysiological mechanisms of ED.Although these findings should be considered preliminary given the small size investigated, SVM analysis highlights the role of well-known brain regions as possible biomarkers to distinguish ED from HC at an individual level, thus encouraging the translational implementation of this new multivariate approach in the clinical practice.

View Article: PubMed Central - PubMed

Affiliation: IBFM-CNR, 88100 Catanzaro, Italy.

ABSTRACT
Presently, there are no valid biomarkers to identify individuals with eating disorders (ED). The aim of this work was to assess the feasibility of a machine learning method for extracting reliable neuroimaging features allowing individual categorization of patients with ED. Support Vector Machine (SVM) technique, combined with a pattern recognition method, was employed utilizing structural magnetic resonance images. Seventeen females with ED (six with diagnosis of anorexia nervosa and 11 with bulimia nervosa) were compared against 17 body mass index-matched healthy controls (HC). Machine learning allowed individual diagnosis of ED versus HC with an Accuracy ≥ 0.80. Voxel-based pattern recognition analysis demonstrated that voxels influencing the classification Accuracy involved the occipital cortex, the posterior cerebellar lobule, precuneus, sensorimotor/premotor cortices, and the medial prefrontal cortex, all critical regions known to be strongly involved in the pathophysiological mechanisms of ED. Although these findings should be considered preliminary given the small size investigated, SVM analysis highlights the role of well-known brain regions as possible biomarkers to distinguish ED from HC at an individual level, thus encouraging the translational implementation of this new multivariate approach in the clinical practice.

Show MeSH
Related in: MedlinePlus