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Circulating Levels of Betatrophin and Irisin Are Not Associated with Pancreatic β-Cell Function in Previously Diagnosed Type 2 Diabetes Mellitus Patients.

Wang L, Song J, Wang C, Lin P, Liang K, Sun Y, He T, Li W, Zhao R, Qin J, Lu Y, Liu J, Liu F, Hou X, Chen L - J Diabetes Res (2015)

Bottom Line: Our results showed that betatrophin levels were significantly elevated, while irisin levels were significantly decreased, in patients with T2DM compared with NGT subjects.However, partial correlation analysis showed that betatrophin levels did not correlate with β-cell function-related variables or insulin resistance-related variables before or after controlling multiple covariates, while irisin correlated positively with insulin sensitivity but is not associated with β-cell function-related variables.Hence we concluded that betatrophin and irisin were not associated with β-cell function in previously diagnosed T2DM patients.

View Article: PubMed Central - PubMed

Affiliation: Department of Endocrinology, Qilu Hospital of Shandong University, Jinan, Shandong 250012, China.

ABSTRACT
Betatrophin and irisin are two recently identified hormones which may participate in regulating pancreatic β-cell function. However, the associations of these two hormones with β-cell function remain unclear. The present study aims to demonstrate the associations of circulating betatrophin and irisin levels with β-cell function, assessed by the area under the curve (AUC) of C-peptide, and the possible correlation between these two hormones in previously diagnosed type 2 diabetes mellitus (T2DM) patients. In total, 20 age-, sex-, and body mass index- (BMI-) matched normal glucose tolerance (NGT) subjects and 120 previously diagnosed T2DM patients were included in this study. Partial correlation analysis was used to evaluate the relationships between these two hormones and indexes of β-cell function and insulin resistance. Our results showed that betatrophin levels were significantly elevated, while irisin levels were significantly decreased, in patients with T2DM compared with NGT subjects. However, partial correlation analysis showed that betatrophin levels did not correlate with β-cell function-related variables or insulin resistance-related variables before or after controlling multiple covariates, while irisin correlated positively with insulin sensitivity but is not associated with β-cell function-related variables. Besides, no correlation was observed between betatrophin and irisin levels. Hence we concluded that betatrophin and irisin were not associated with β-cell function in previously diagnosed T2DM patients.

No MeSH data available.


Related in: MedlinePlus

Correlation between irisin levels and glucose-related variables in T2DM subjects.
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Related In: Results  -  Collection


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fig2: Correlation between irisin levels and glucose-related variables in T2DM subjects.

Mentions: The correlations between irisin levels and glucose-related variables based on the values of 120 individual T2DM subjects were shown in Table 4 and Figure 2. Similar to the betatrophin, irisin levels were not associated with β-cell function either. However, it is positively associated with HOMA2-%S, even after controlling multiple covariates.


Circulating Levels of Betatrophin and Irisin Are Not Associated with Pancreatic β-Cell Function in Previously Diagnosed Type 2 Diabetes Mellitus Patients.

Wang L, Song J, Wang C, Lin P, Liang K, Sun Y, He T, Li W, Zhao R, Qin J, Lu Y, Liu J, Liu F, Hou X, Chen L - J Diabetes Res (2015)

Correlation between irisin levels and glucose-related variables in T2DM subjects.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4663363&req=5

fig2: Correlation between irisin levels and glucose-related variables in T2DM subjects.
Mentions: The correlations between irisin levels and glucose-related variables based on the values of 120 individual T2DM subjects were shown in Table 4 and Figure 2. Similar to the betatrophin, irisin levels were not associated with β-cell function either. However, it is positively associated with HOMA2-%S, even after controlling multiple covariates.

Bottom Line: Our results showed that betatrophin levels were significantly elevated, while irisin levels were significantly decreased, in patients with T2DM compared with NGT subjects.However, partial correlation analysis showed that betatrophin levels did not correlate with β-cell function-related variables or insulin resistance-related variables before or after controlling multiple covariates, while irisin correlated positively with insulin sensitivity but is not associated with β-cell function-related variables.Hence we concluded that betatrophin and irisin were not associated with β-cell function in previously diagnosed T2DM patients.

View Article: PubMed Central - PubMed

Affiliation: Department of Endocrinology, Qilu Hospital of Shandong University, Jinan, Shandong 250012, China.

ABSTRACT
Betatrophin and irisin are two recently identified hormones which may participate in regulating pancreatic β-cell function. However, the associations of these two hormones with β-cell function remain unclear. The present study aims to demonstrate the associations of circulating betatrophin and irisin levels with β-cell function, assessed by the area under the curve (AUC) of C-peptide, and the possible correlation between these two hormones in previously diagnosed type 2 diabetes mellitus (T2DM) patients. In total, 20 age-, sex-, and body mass index- (BMI-) matched normal glucose tolerance (NGT) subjects and 120 previously diagnosed T2DM patients were included in this study. Partial correlation analysis was used to evaluate the relationships between these two hormones and indexes of β-cell function and insulin resistance. Our results showed that betatrophin levels were significantly elevated, while irisin levels were significantly decreased, in patients with T2DM compared with NGT subjects. However, partial correlation analysis showed that betatrophin levels did not correlate with β-cell function-related variables or insulin resistance-related variables before or after controlling multiple covariates, while irisin correlated positively with insulin sensitivity but is not associated with β-cell function-related variables. Besides, no correlation was observed between betatrophin and irisin levels. Hence we concluded that betatrophin and irisin were not associated with β-cell function in previously diagnosed T2DM patients.

No MeSH data available.


Related in: MedlinePlus