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Distinct Functions of Neutrophil in Cancer and Its Regulation.

Granot Z, Jablonska J - Mediators Inflamm. (2015)

Bottom Line: Neutrophils are the most abundant of all white blood cells in the human circulation and are usually associated with inflammation and with fighting infections.In recent years the role immune cells play in cancer has been a matter of increasing interest.Here we provide an up-to-date review of the pro- and antitumor properties neutrophils possess as well as the environmental cues that regulate these distinct functions.

View Article: PubMed Central - PubMed

Affiliation: Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, 91120 Jerusalem, Israel.

ABSTRACT
Neutrophils are the most abundant of all white blood cells in the human circulation and are usually associated with inflammation and with fighting infections. In recent years the role immune cells play in cancer has been a matter of increasing interest. In this context the function of neutrophils is controversial as neutrophils were shown to possess both tumor promoting and tumor limiting properties. Here we provide an up-to-date review of the pro- and antitumor properties neutrophils possess as well as the environmental cues that regulate these distinct functions.

No MeSH data available.


Related in: MedlinePlus

Neutrophil function in cancer is dictated by environmental cues. Neutrophils may be divided into N1 antitumor and N2 protumor cells. TGFβ is a potent driver of the transition from N1 to N2 phenotype whereas IFN-β is a potent driver of the transition in the opposite direction. This exemplifies the notion that neutrophil function in cancer is determined by the chemokine milieu in the microenvironment.
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fig1: Neutrophil function in cancer is dictated by environmental cues. Neutrophils may be divided into N1 antitumor and N2 protumor cells. TGFβ is a potent driver of the transition from N1 to N2 phenotype whereas IFN-β is a potent driver of the transition in the opposite direction. This exemplifies the notion that neutrophil function in cancer is determined by the chemokine milieu in the microenvironment.

Mentions: The conflicting effects of TGFβ and IFNs on neutrophil function in the context of cancer are an example of how neutrophils respond to cues in the microenvironment (Figure 1). While understanding the mechanisms that regulate neutrophil function is clearly important from a therapeutic point of view, the realization that neutrophils may play conflicting roles, depending on their context, is an important notion.


Distinct Functions of Neutrophil in Cancer and Its Regulation.

Granot Z, Jablonska J - Mediators Inflamm. (2015)

Neutrophil function in cancer is dictated by environmental cues. Neutrophils may be divided into N1 antitumor and N2 protumor cells. TGFβ is a potent driver of the transition from N1 to N2 phenotype whereas IFN-β is a potent driver of the transition in the opposite direction. This exemplifies the notion that neutrophil function in cancer is determined by the chemokine milieu in the microenvironment.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4663337&req=5

fig1: Neutrophil function in cancer is dictated by environmental cues. Neutrophils may be divided into N1 antitumor and N2 protumor cells. TGFβ is a potent driver of the transition from N1 to N2 phenotype whereas IFN-β is a potent driver of the transition in the opposite direction. This exemplifies the notion that neutrophil function in cancer is determined by the chemokine milieu in the microenvironment.
Mentions: The conflicting effects of TGFβ and IFNs on neutrophil function in the context of cancer are an example of how neutrophils respond to cues in the microenvironment (Figure 1). While understanding the mechanisms that regulate neutrophil function is clearly important from a therapeutic point of view, the realization that neutrophils may play conflicting roles, depending on their context, is an important notion.

Bottom Line: Neutrophils are the most abundant of all white blood cells in the human circulation and are usually associated with inflammation and with fighting infections.In recent years the role immune cells play in cancer has been a matter of increasing interest.Here we provide an up-to-date review of the pro- and antitumor properties neutrophils possess as well as the environmental cues that regulate these distinct functions.

View Article: PubMed Central - PubMed

Affiliation: Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, 91120 Jerusalem, Israel.

ABSTRACT
Neutrophils are the most abundant of all white blood cells in the human circulation and are usually associated with inflammation and with fighting infections. In recent years the role immune cells play in cancer has been a matter of increasing interest. In this context the function of neutrophils is controversial as neutrophils were shown to possess both tumor promoting and tumor limiting properties. Here we provide an up-to-date review of the pro- and antitumor properties neutrophils possess as well as the environmental cues that regulate these distinct functions.

No MeSH data available.


Related in: MedlinePlus