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Longxuetongluo Capsule Improves Erythrocyte Function against Lipid Peroxidation and Abnormal Hemorheological Parameters in High Fat Diet-Induced ApoE-/- Mice.

Zheng J, Liu B, Lun Q, Yao W, Zhao Y, Xiao W, Huang W, Wang Y, Li J, Tu P - Oxid Med Cell Longev (2015)

Bottom Line: Phenolic compounds are considered to be responsible for its main biological activities.In this study, total phenolic compounds of Chinese dragon's blood were made into capsule (Longxuetongluo Capsule, LTC) and their effects on the abnormal hemorheological properties were examined by high fat diet (HFD) induced ApoE-/- mice.In conclusion, LTC could ameliorate erythrocyte deformability and osmotic fragility through the reduction of lipid peroxidation on plasma and erythrocyte membranes in HFD-induced ApoE-/- mice, which supported the traditional uses of Chinese dragon's blood as an effective agent for improving blood microcirculation in hypercholesterolemia.

View Article: PubMed Central - PubMed

Affiliation: Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China.

ABSTRACT
Chinese dragon's blood, the red resin of Dracaena cochinchinensis, one of the renowned traditional medicines, has been used to facilitate blood circulation and disperse blood stasis for thousands of years. Phenolic compounds are considered to be responsible for its main biological activities. In this study, total phenolic compounds of Chinese dragon's blood were made into capsule (Longxuetongluo Capsule, LTC) and their effects on the abnormal hemorheological properties were examined by high fat diet (HFD) induced ApoE-/- mice. Compared to the model group, LTC recovered the abnormal hemorheological parameters in HFD-induced ApoE-/- mice by reducing whole blood viscosity (WBV) at high rate and improving erythrocyte function. In conclusion, LTC could ameliorate erythrocyte deformability and osmotic fragility through the reduction of lipid peroxidation on plasma and erythrocyte membranes in HFD-induced ApoE-/- mice, which supported the traditional uses of Chinese dragon's blood as an effective agent for improving blood microcirculation in hypercholesterolemia.

No MeSH data available.


Related in: MedlinePlus

Morphological changes of erythrocytes in HFD-induced and LTC-treated mice observed with scanning electron microscope. (a) Erythrocytes of HFD-induced mice deformed with protrusions or irregular appearances. (b) Erythrocytes of LTC-treated (300 mg/kg) mice presented the more typical discocytes with rare deformed cells. (c) Erythrocytes of ezetimibe-treated mice presented the more typical discocytes with rare deformed cells.
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fig6: Morphological changes of erythrocytes in HFD-induced and LTC-treated mice observed with scanning electron microscope. (a) Erythrocytes of HFD-induced mice deformed with protrusions or irregular appearances. (b) Erythrocytes of LTC-treated (300 mg/kg) mice presented the more typical discocytes with rare deformed cells. (c) Erythrocytes of ezetimibe-treated mice presented the more typical discocytes with rare deformed cells.

Mentions: The scanning electron microscopy demonstrated profound morphology alterations of erythrocytes by LTC treatment at dose of 300 mg/kg as shown in Figure 6. For the HFD-induced mice, most erythrocytes were deformed with protrusions or irregular appearances (Figure 6, arrows), and the abnormal erythrocyte morphology had been improved after LTC treatment.


Longxuetongluo Capsule Improves Erythrocyte Function against Lipid Peroxidation and Abnormal Hemorheological Parameters in High Fat Diet-Induced ApoE-/- Mice.

Zheng J, Liu B, Lun Q, Yao W, Zhao Y, Xiao W, Huang W, Wang Y, Li J, Tu P - Oxid Med Cell Longev (2015)

Morphological changes of erythrocytes in HFD-induced and LTC-treated mice observed with scanning electron microscope. (a) Erythrocytes of HFD-induced mice deformed with protrusions or irregular appearances. (b) Erythrocytes of LTC-treated (300 mg/kg) mice presented the more typical discocytes with rare deformed cells. (c) Erythrocytes of ezetimibe-treated mice presented the more typical discocytes with rare deformed cells.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4663336&req=5

fig6: Morphological changes of erythrocytes in HFD-induced and LTC-treated mice observed with scanning electron microscope. (a) Erythrocytes of HFD-induced mice deformed with protrusions or irregular appearances. (b) Erythrocytes of LTC-treated (300 mg/kg) mice presented the more typical discocytes with rare deformed cells. (c) Erythrocytes of ezetimibe-treated mice presented the more typical discocytes with rare deformed cells.
Mentions: The scanning electron microscopy demonstrated profound morphology alterations of erythrocytes by LTC treatment at dose of 300 mg/kg as shown in Figure 6. For the HFD-induced mice, most erythrocytes were deformed with protrusions or irregular appearances (Figure 6, arrows), and the abnormal erythrocyte morphology had been improved after LTC treatment.

Bottom Line: Phenolic compounds are considered to be responsible for its main biological activities.In this study, total phenolic compounds of Chinese dragon's blood were made into capsule (Longxuetongluo Capsule, LTC) and their effects on the abnormal hemorheological properties were examined by high fat diet (HFD) induced ApoE-/- mice.In conclusion, LTC could ameliorate erythrocyte deformability and osmotic fragility through the reduction of lipid peroxidation on plasma and erythrocyte membranes in HFD-induced ApoE-/- mice, which supported the traditional uses of Chinese dragon's blood as an effective agent for improving blood microcirculation in hypercholesterolemia.

View Article: PubMed Central - PubMed

Affiliation: Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China.

ABSTRACT
Chinese dragon's blood, the red resin of Dracaena cochinchinensis, one of the renowned traditional medicines, has been used to facilitate blood circulation and disperse blood stasis for thousands of years. Phenolic compounds are considered to be responsible for its main biological activities. In this study, total phenolic compounds of Chinese dragon's blood were made into capsule (Longxuetongluo Capsule, LTC) and their effects on the abnormal hemorheological properties were examined by high fat diet (HFD) induced ApoE-/- mice. Compared to the model group, LTC recovered the abnormal hemorheological parameters in HFD-induced ApoE-/- mice by reducing whole blood viscosity (WBV) at high rate and improving erythrocyte function. In conclusion, LTC could ameliorate erythrocyte deformability and osmotic fragility through the reduction of lipid peroxidation on plasma and erythrocyte membranes in HFD-induced ApoE-/- mice, which supported the traditional uses of Chinese dragon's blood as an effective agent for improving blood microcirculation in hypercholesterolemia.

No MeSH data available.


Related in: MedlinePlus