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Roles of Hsp70s in Stress Responses of Microorganisms, Plants, and Animals.

Yu A, Li P, Tang T, Wang J, Chen Y, Liu L - Biomed Res Int (2015)

Bottom Line: Most research on Hsp70s has focused on the mechanisms of their functions as molecular chaperones, but recently, studies on stress responses are coming to the forefront.Moreover, functions of human Hsp70s are related to diseases including neurological disorders, cancer, and virus infection.In this review, we provide an overview of the specific roles of Hsp70s in response to stress, particularly abiotic stress, in all living organisms.

View Article: PubMed Central - PubMed

Affiliation: Key Laboratory of Economic Plants and Biotechnology, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan 650201, China ; Yunnan Key Laboratory for Wild Plant Resources, Kunming, Yunnan 650201, China.

ABSTRACT
Hsp70s (heat shock protein 70s) are a class of molecular chaperones that are highly conserved and ubiquitous in organisms ranging from microorganisms to plants and humans. Most research on Hsp70s has focused on the mechanisms of their functions as molecular chaperones, but recently, studies on stress responses are coming to the forefront. Hsp70s play key roles in cellular development and protecting living organisms from environmental stresses such as heat, drought, salinity, acidity, and cold. Moreover, functions of human Hsp70s are related to diseases including neurological disorders, cancer, and virus infection. In this review, we provide an overview of the specific roles of Hsp70s in response to stress, particularly abiotic stress, in all living organisms.

No MeSH data available.


Related in: MedlinePlus

Phylogenetic tree of Hsp70 family in rice.
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fig2: Phylogenetic tree of Hsp70 family in rice.

Mentions: Hsp70s were first discovered in fruit flies in the 1960s when a lab worker accidentally increased the incubation temperature, and the basic function of these proteins is recognized to be as molecular chaperones [24]. Hsp70s are evolutionarily highly conserved. In plants, mitochondrial and plastid Hsp70s have relatively high sequence similarity to DnaK (the bacterial Hsp70 homolog), ranging from 50% to 63%, while the other Hsp70s members are more closely related to cytosolic Hsp70s [25]. The cytosolic Hsp70 family members display up to 75% amino acid identity to other plant Hsp70 proteins of this group [26]. The sequences of Hsp70 homologs from the different compartmentations have similarity and peculiarity with each other. According to those foregoing researches, ER arise from the early stages of the eukaryotic cell, while mitochondria and chloroplast are the accepted endosymbiotic origin organelles. Here we showed an example in rice (Figure 2). From the phylogenetic tree of Hsp70 family in rice, we can clearly see that the evolutionary relation of those Hsp70s is consistent with the origin of compartmentations.


Roles of Hsp70s in Stress Responses of Microorganisms, Plants, and Animals.

Yu A, Li P, Tang T, Wang J, Chen Y, Liu L - Biomed Res Int (2015)

Phylogenetic tree of Hsp70 family in rice.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4663327&req=5

fig2: Phylogenetic tree of Hsp70 family in rice.
Mentions: Hsp70s were first discovered in fruit flies in the 1960s when a lab worker accidentally increased the incubation temperature, and the basic function of these proteins is recognized to be as molecular chaperones [24]. Hsp70s are evolutionarily highly conserved. In plants, mitochondrial and plastid Hsp70s have relatively high sequence similarity to DnaK (the bacterial Hsp70 homolog), ranging from 50% to 63%, while the other Hsp70s members are more closely related to cytosolic Hsp70s [25]. The cytosolic Hsp70 family members display up to 75% amino acid identity to other plant Hsp70 proteins of this group [26]. The sequences of Hsp70 homologs from the different compartmentations have similarity and peculiarity with each other. According to those foregoing researches, ER arise from the early stages of the eukaryotic cell, while mitochondria and chloroplast are the accepted endosymbiotic origin organelles. Here we showed an example in rice (Figure 2). From the phylogenetic tree of Hsp70 family in rice, we can clearly see that the evolutionary relation of those Hsp70s is consistent with the origin of compartmentations.

Bottom Line: Most research on Hsp70s has focused on the mechanisms of their functions as molecular chaperones, but recently, studies on stress responses are coming to the forefront.Moreover, functions of human Hsp70s are related to diseases including neurological disorders, cancer, and virus infection.In this review, we provide an overview of the specific roles of Hsp70s in response to stress, particularly abiotic stress, in all living organisms.

View Article: PubMed Central - PubMed

Affiliation: Key Laboratory of Economic Plants and Biotechnology, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan 650201, China ; Yunnan Key Laboratory for Wild Plant Resources, Kunming, Yunnan 650201, China.

ABSTRACT
Hsp70s (heat shock protein 70s) are a class of molecular chaperones that are highly conserved and ubiquitous in organisms ranging from microorganisms to plants and humans. Most research on Hsp70s has focused on the mechanisms of their functions as molecular chaperones, but recently, studies on stress responses are coming to the forefront. Hsp70s play key roles in cellular development and protecting living organisms from environmental stresses such as heat, drought, salinity, acidity, and cold. Moreover, functions of human Hsp70s are related to diseases including neurological disorders, cancer, and virus infection. In this review, we provide an overview of the specific roles of Hsp70s in response to stress, particularly abiotic stress, in all living organisms.

No MeSH data available.


Related in: MedlinePlus