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The Importance of Stochastic Effects for Explaining Entrainment in the Zebrafish Circadian Clock.

Heussen R, Whitmore D - Comput Math Methods Med (2015)

Bottom Line: Here we investigate how the circadian clock is entrained by external cues such as light.Working with zebrafish cell lines and combining light pulse experiments with simulation efforts focused on the role of synchronization effects, we find that even very modest doses of light exposure are sufficient to trigger some entrainment, whereby a higher light intensity or duration correlates with strength of the circadian signal.Moreover, we observe in the simulations that stochastic effects may be considered an essential feature of the circadian clock in order to explain the circadian signal decay in prolonged darkness, as well as light initiated resynchronization as a strong component of entrainment.

View Article: PubMed Central - PubMed

Affiliation: CoMPLEX, UCL, Physics Building, Gower Place, London WC1E 6BT, UK.

ABSTRACT
The circadian clock plays a pivotal role in modulating physiological processes and has been implicated, either directly or indirectly, in a range of pathological states including cancer. Here we investigate how the circadian clock is entrained by external cues such as light. Working with zebrafish cell lines and combining light pulse experiments with simulation efforts focused on the role of synchronization effects, we find that even very modest doses of light exposure are sufficient to trigger some entrainment, whereby a higher light intensity or duration correlates with strength of the circadian signal. Moreover, we observe in the simulations that stochastic effects may be considered an essential feature of the circadian clock in order to explain the circadian signal decay in prolonged darkness, as well as light initiated resynchronization as a strong component of entrainment.

No MeSH data available.


Related in: MedlinePlus

Decay rate of amplitude after exposure to light pulses of different duration (15 minutes or 1 hour) and light intensities. Decay rate and amplitude are shown for the different length of light pulse and intensities of light. Additionally, the first complete cycle of the original detrended data was ignored for the cut data set.
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fig4: Decay rate of amplitude after exposure to light pulses of different duration (15 minutes or 1 hour) and light intensities. Decay rate and amplitude are shown for the different length of light pulse and intensities of light. Additionally, the first complete cycle of the original detrended data was ignored for the cut data set.

Mentions: The traces were detrended using a 24-hour moving average and the amplitude after the light pulse and the decay rate were determined using a Hilbert Transform. The results of the decay rate and amplitude analysis can be seen in Figure 4.


The Importance of Stochastic Effects for Explaining Entrainment in the Zebrafish Circadian Clock.

Heussen R, Whitmore D - Comput Math Methods Med (2015)

Decay rate of amplitude after exposure to light pulses of different duration (15 minutes or 1 hour) and light intensities. Decay rate and amplitude are shown for the different length of light pulse and intensities of light. Additionally, the first complete cycle of the original detrended data was ignored for the cut data set.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4663325&req=5

fig4: Decay rate of amplitude after exposure to light pulses of different duration (15 minutes or 1 hour) and light intensities. Decay rate and amplitude are shown for the different length of light pulse and intensities of light. Additionally, the first complete cycle of the original detrended data was ignored for the cut data set.
Mentions: The traces were detrended using a 24-hour moving average and the amplitude after the light pulse and the decay rate were determined using a Hilbert Transform. The results of the decay rate and amplitude analysis can be seen in Figure 4.

Bottom Line: Here we investigate how the circadian clock is entrained by external cues such as light.Working with zebrafish cell lines and combining light pulse experiments with simulation efforts focused on the role of synchronization effects, we find that even very modest doses of light exposure are sufficient to trigger some entrainment, whereby a higher light intensity or duration correlates with strength of the circadian signal.Moreover, we observe in the simulations that stochastic effects may be considered an essential feature of the circadian clock in order to explain the circadian signal decay in prolonged darkness, as well as light initiated resynchronization as a strong component of entrainment.

View Article: PubMed Central - PubMed

Affiliation: CoMPLEX, UCL, Physics Building, Gower Place, London WC1E 6BT, UK.

ABSTRACT
The circadian clock plays a pivotal role in modulating physiological processes and has been implicated, either directly or indirectly, in a range of pathological states including cancer. Here we investigate how the circadian clock is entrained by external cues such as light. Working with zebrafish cell lines and combining light pulse experiments with simulation efforts focused on the role of synchronization effects, we find that even very modest doses of light exposure are sufficient to trigger some entrainment, whereby a higher light intensity or duration correlates with strength of the circadian signal. Moreover, we observe in the simulations that stochastic effects may be considered an essential feature of the circadian clock in order to explain the circadian signal decay in prolonged darkness, as well as light initiated resynchronization as a strong component of entrainment.

No MeSH data available.


Related in: MedlinePlus