Limits...
A Literature Review and Case Report of Metastatic Pure Choriocarcinoma.

Lin D, Tan AJ, Singh-Rai R - Case Rep Oncol Med (2015)

Bottom Line: In 2012, testicular cancer was estimated to account for 940 disability adjusted life years in Australia; of these, 450 were years lost due to premature death and 500 were years of healthy life lost due to disease, disability, or injury (Australian Institute of Health and Welfare and Australasian Association of Cancer Registries, 2012).Even then, prognosis is poor.This case report describes a 20-year-old male with pure testicular choriocarcinoma with pulmonary metastases which showed sustained and complete response to adjuvant chemotherapy consisting of bleomycin, etoposide, and cisplatin.

View Article: PubMed Central - PubMed

Affiliation: Division of Surgery, Lyell McEwin Hospital, Adelaide, SA, Australia.

ABSTRACT
In 2012, testicular cancer was estimated to account for 940 disability adjusted life years in Australia; of these, 450 were years lost due to premature death and 500 were years of healthy life lost due to disease, disability, or injury (Australian Institute of Health and Welfare and Australasian Association of Cancer Registries, 2012). Testicular choriocarcinoma is one of the rarest variants of testicular germ cell tumours, accounting for less than 1% of testicular germ cell tumours and only about 0.19% of all testicular tumours. Management involves radical orchidectomy and chemotherapy. Even then, prognosis is poor. This case report describes a 20-year-old male with pure testicular choriocarcinoma with pulmonary metastases which showed sustained and complete response to adjuvant chemotherapy consisting of bleomycin, etoposide, and cisplatin.

No MeSH data available.


Related in: MedlinePlus

Entire tumour composed of choriocarcinoma characterised by an admixture of syncytiotrophoblastic and cytotrophoblastic cells.
© Copyright Policy
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4663315&req=5

fig2: Entire tumour composed of choriocarcinoma characterised by an admixture of syncytiotrophoblastic and cytotrophoblastic cells.

Mentions: Histological macroscopic examination showed an enlarged testis which was almost completely replaced by an extensively haemorrhagic, centrally necrotic tumour which measured 76 × 74 × 53 mm (Figure 1). The spermatic cord was normal in appearance. The testicular mass was extensively sampled and representative sections were taken from the spermatic cord. Microscopic examination revealed that the entire tumour was composed of choriocarcinoma characterised by an admixture of syncytiotrophoblastic and cytotrophoblastic cells (Figure 2). The syncytiotrophoblastic cells were positive for HCG and both components were negative for AFP, CD30, and cytokeratins. No other germ cell tumour elements were identified in the many sections examined. Vascular invasion was present in several areas and focal rete testis infiltration was present. There was no invasion of the tunica albuginea or the spermatic cord. Intratubular germ cell neoplasia (ITGCN) was also present in the remnant testicular parenchyma. The AJCC TNM system stage was pT2 N0 M1a.


A Literature Review and Case Report of Metastatic Pure Choriocarcinoma.

Lin D, Tan AJ, Singh-Rai R - Case Rep Oncol Med (2015)

Entire tumour composed of choriocarcinoma characterised by an admixture of syncytiotrophoblastic and cytotrophoblastic cells.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4663315&req=5

fig2: Entire tumour composed of choriocarcinoma characterised by an admixture of syncytiotrophoblastic and cytotrophoblastic cells.
Mentions: Histological macroscopic examination showed an enlarged testis which was almost completely replaced by an extensively haemorrhagic, centrally necrotic tumour which measured 76 × 74 × 53 mm (Figure 1). The spermatic cord was normal in appearance. The testicular mass was extensively sampled and representative sections were taken from the spermatic cord. Microscopic examination revealed that the entire tumour was composed of choriocarcinoma characterised by an admixture of syncytiotrophoblastic and cytotrophoblastic cells (Figure 2). The syncytiotrophoblastic cells were positive for HCG and both components were negative for AFP, CD30, and cytokeratins. No other germ cell tumour elements were identified in the many sections examined. Vascular invasion was present in several areas and focal rete testis infiltration was present. There was no invasion of the tunica albuginea or the spermatic cord. Intratubular germ cell neoplasia (ITGCN) was also present in the remnant testicular parenchyma. The AJCC TNM system stage was pT2 N0 M1a.

Bottom Line: In 2012, testicular cancer was estimated to account for 940 disability adjusted life years in Australia; of these, 450 were years lost due to premature death and 500 were years of healthy life lost due to disease, disability, or injury (Australian Institute of Health and Welfare and Australasian Association of Cancer Registries, 2012).Even then, prognosis is poor.This case report describes a 20-year-old male with pure testicular choriocarcinoma with pulmonary metastases which showed sustained and complete response to adjuvant chemotherapy consisting of bleomycin, etoposide, and cisplatin.

View Article: PubMed Central - PubMed

Affiliation: Division of Surgery, Lyell McEwin Hospital, Adelaide, SA, Australia.

ABSTRACT
In 2012, testicular cancer was estimated to account for 940 disability adjusted life years in Australia; of these, 450 were years lost due to premature death and 500 were years of healthy life lost due to disease, disability, or injury (Australian Institute of Health and Welfare and Australasian Association of Cancer Registries, 2012). Testicular choriocarcinoma is one of the rarest variants of testicular germ cell tumours, accounting for less than 1% of testicular germ cell tumours and only about 0.19% of all testicular tumours. Management involves radical orchidectomy and chemotherapy. Even then, prognosis is poor. This case report describes a 20-year-old male with pure testicular choriocarcinoma with pulmonary metastases which showed sustained and complete response to adjuvant chemotherapy consisting of bleomycin, etoposide, and cisplatin.

No MeSH data available.


Related in: MedlinePlus