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Myocardial Injury in Children with Unoperated Congenital Heart Diseases.

Hafez MO, Morsy SM, Mahfoz RA, Ali AR - Cardiol Res Pract (2015)

Bottom Line: Serum cTnI was significantly higher in both cyanotic and acyanotic groups compared to control group (p < 0.05).Serum cTnI level significantly correlated with oxygen saturation (SpO2), ejection fraction (EF), Qp/Qs, and Pp/Ps ratios.Conclusion.

View Article: PubMed Central - PubMed

Affiliation: Pediatrics Department, Faculty of Medicine, Zagazig University, Zagazig 44519, Egypt.

ABSTRACT
Background. Children with congenital heart diseases (CHDs) may have a risk of developing myocardial injury caused by volume and pressure overload. Objective. To evaluate the incidence of myocardial injury in children with cyanotic and acyanotic CHDs using cTnI assay and to correlate it with different hemodynamic parameters. Methods. This study included 80 children with CHDs (40 acyanotic and 40 cyanotic) as well as 40 healthy children (control group). Serum cTnI levels were measured for patients and control. Pulmonary to systemic blood flow (Qp/Qs) and pulmonary to systemic arterial pressure (Pp/Ps) ratios were measured for children with CHDs during cardiac catheterization. Results. Sixty-four out of 80 patients with CHDs had myocardial injury as evidenced by increased cTnI. Serum cTnI was significantly higher in both cyanotic and acyanotic groups compared to control group (p < 0.05). Serum cTnI level significantly correlated with oxygen saturation (SpO2), ejection fraction (EF), Qp/Qs, and Pp/Ps ratios. Conclusion. The incidence of myocardial injury was high in children with CHDs. The use of cTnI for follow-up of children with CHDs may help early detection of myocardial injury and help early management of these cases.

No MeSH data available.


Related in: MedlinePlus

Box-plot shows cTnI levels in the ASD, VSD, and PDA patients. The bars represent the median and the 5th, 25th, 75th, and 95th percentiles.
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fig1: Box-plot shows cTnI levels in the ASD, VSD, and PDA patients. The bars represent the median and the 5th, 25th, 75th, and 95th percentiles.

Mentions: Regarding specific cardiac lesions, cTnI level was higher in patients with VSD and those with PDA compared to patients with ASD. However, no difference was found between patients with VSD and those with PDA (Table 4 and Figure 1). Also, serum cTnI level was significantly higher in patients with TGA than those with TOF (Table 4 and Figure 2).


Myocardial Injury in Children with Unoperated Congenital Heart Diseases.

Hafez MO, Morsy SM, Mahfoz RA, Ali AR - Cardiol Res Pract (2015)

Box-plot shows cTnI levels in the ASD, VSD, and PDA patients. The bars represent the median and the 5th, 25th, 75th, and 95th percentiles.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4663296&req=5

fig1: Box-plot shows cTnI levels in the ASD, VSD, and PDA patients. The bars represent the median and the 5th, 25th, 75th, and 95th percentiles.
Mentions: Regarding specific cardiac lesions, cTnI level was higher in patients with VSD and those with PDA compared to patients with ASD. However, no difference was found between patients with VSD and those with PDA (Table 4 and Figure 1). Also, serum cTnI level was significantly higher in patients with TGA than those with TOF (Table 4 and Figure 2).

Bottom Line: Serum cTnI was significantly higher in both cyanotic and acyanotic groups compared to control group (p < 0.05).Serum cTnI level significantly correlated with oxygen saturation (SpO2), ejection fraction (EF), Qp/Qs, and Pp/Ps ratios.Conclusion.

View Article: PubMed Central - PubMed

Affiliation: Pediatrics Department, Faculty of Medicine, Zagazig University, Zagazig 44519, Egypt.

ABSTRACT
Background. Children with congenital heart diseases (CHDs) may have a risk of developing myocardial injury caused by volume and pressure overload. Objective. To evaluate the incidence of myocardial injury in children with cyanotic and acyanotic CHDs using cTnI assay and to correlate it with different hemodynamic parameters. Methods. This study included 80 children with CHDs (40 acyanotic and 40 cyanotic) as well as 40 healthy children (control group). Serum cTnI levels were measured for patients and control. Pulmonary to systemic blood flow (Qp/Qs) and pulmonary to systemic arterial pressure (Pp/Ps) ratios were measured for children with CHDs during cardiac catheterization. Results. Sixty-four out of 80 patients with CHDs had myocardial injury as evidenced by increased cTnI. Serum cTnI was significantly higher in both cyanotic and acyanotic groups compared to control group (p < 0.05). Serum cTnI level significantly correlated with oxygen saturation (SpO2), ejection fraction (EF), Qp/Qs, and Pp/Ps ratios. Conclusion. The incidence of myocardial injury was high in children with CHDs. The use of cTnI for follow-up of children with CHDs may help early detection of myocardial injury and help early management of these cases.

No MeSH data available.


Related in: MedlinePlus