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Impaired Autonomic Responses to Emotional Stimuli in Autoimmune Limbic Encephalitis.

Schröder O, Schriewer E, Golombeck KS, Kürten J, Lohmann H, Schwindt W, Wiendl H, Bruchmann M, Melzer N, Straube T - Front Neurol (2015)

Bottom Line: The amygdala constitutes a brain area substantial for processing of emotional, especially fear-related signals.There was no comparable impairment in behavioral data (emotion report, valence, and arousal ratings).The results point to a defective modulation of sympathetic responses during emotional stimulation in patients with LE, probably due to impaired functioning of the amygdala.

View Article: PubMed Central - PubMed

Affiliation: Institute of Medical Psychology and Systems Neuroscience, University of Muenster , Muenster , Germany.

ABSTRACT
Limbic encephalitis (LE) is an autoimmune-mediated disorder that affects structures of the limbic system, in particular, the amygdala. The amygdala constitutes a brain area substantial for processing of emotional, especially fear-related signals. The amygdala is also involved in neuroendocrine and autonomic functions, including skin conductance responses (SCRs) to emotionally arousing stimuli. This study investigates behavioral and autonomic responses to discrete emotion evoking and neutral film clips in a patient suffering from LE associated with contactin-associated protein-2 (CASPR2) antibodies as compared to a healthy control group. Results show a lack of SCRs in the patient while watching the film clips, with significant differences compared to healthy controls in the case of fear-inducing videos. There was no comparable impairment in behavioral data (emotion report, valence, and arousal ratings). The results point to a defective modulation of sympathetic responses during emotional stimulation in patients with LE, probably due to impaired functioning of the amygdala.

No MeSH data available.


Related in: MedlinePlus

Results of physiological reactivity: R.B.’s electrodermal activity during the film clips set (A–F) against a prototypical electrodermal response curve of a healthy control subject. Comparing R.B.’s skin conductance during the respiration measurement with the control group in terms of averaged trough-to-peak distances showed no significant difference, as displayed in the box-plot diagram (G).
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Figure 3: Results of physiological reactivity: R.B.’s electrodermal activity during the film clips set (A–F) against a prototypical electrodermal response curve of a healthy control subject. Comparing R.B.’s skin conductance during the respiration measurement with the control group in terms of averaged trough-to-peak distances showed no significant difference, as displayed in the box-plot diagram (G).

Mentions: On the level of raw scores, R.B. developed no SC responses to any kind of film material presented to him (Table 4), although he had passed the respiration test in the beginning of the experiment without any observable differences to the control group (zrespiration = −0.46). Thus, R.B.’s arousal level appeared not to be affected by any experimental manipulation of emotional stimulation. The control group showed more physiological fluctuations subject to the different emotional content of the stimulus material. These findings are illustrated in Figure 3 by plotting R.B.’s response curve in contrast to a prototypical response curve of a healthy control subject for all experimental conditions applied. Results of the respiration test are included additionally.


Impaired Autonomic Responses to Emotional Stimuli in Autoimmune Limbic Encephalitis.

Schröder O, Schriewer E, Golombeck KS, Kürten J, Lohmann H, Schwindt W, Wiendl H, Bruchmann M, Melzer N, Straube T - Front Neurol (2015)

Results of physiological reactivity: R.B.’s electrodermal activity during the film clips set (A–F) against a prototypical electrodermal response curve of a healthy control subject. Comparing R.B.’s skin conductance during the respiration measurement with the control group in terms of averaged trough-to-peak distances showed no significant difference, as displayed in the box-plot diagram (G).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4663278&req=5

Figure 3: Results of physiological reactivity: R.B.’s electrodermal activity during the film clips set (A–F) against a prototypical electrodermal response curve of a healthy control subject. Comparing R.B.’s skin conductance during the respiration measurement with the control group in terms of averaged trough-to-peak distances showed no significant difference, as displayed in the box-plot diagram (G).
Mentions: On the level of raw scores, R.B. developed no SC responses to any kind of film material presented to him (Table 4), although he had passed the respiration test in the beginning of the experiment without any observable differences to the control group (zrespiration = −0.46). Thus, R.B.’s arousal level appeared not to be affected by any experimental manipulation of emotional stimulation. The control group showed more physiological fluctuations subject to the different emotional content of the stimulus material. These findings are illustrated in Figure 3 by plotting R.B.’s response curve in contrast to a prototypical response curve of a healthy control subject for all experimental conditions applied. Results of the respiration test are included additionally.

Bottom Line: The amygdala constitutes a brain area substantial for processing of emotional, especially fear-related signals.There was no comparable impairment in behavioral data (emotion report, valence, and arousal ratings).The results point to a defective modulation of sympathetic responses during emotional stimulation in patients with LE, probably due to impaired functioning of the amygdala.

View Article: PubMed Central - PubMed

Affiliation: Institute of Medical Psychology and Systems Neuroscience, University of Muenster , Muenster , Germany.

ABSTRACT
Limbic encephalitis (LE) is an autoimmune-mediated disorder that affects structures of the limbic system, in particular, the amygdala. The amygdala constitutes a brain area substantial for processing of emotional, especially fear-related signals. The amygdala is also involved in neuroendocrine and autonomic functions, including skin conductance responses (SCRs) to emotionally arousing stimuli. This study investigates behavioral and autonomic responses to discrete emotion evoking and neutral film clips in a patient suffering from LE associated with contactin-associated protein-2 (CASPR2) antibodies as compared to a healthy control group. Results show a lack of SCRs in the patient while watching the film clips, with significant differences compared to healthy controls in the case of fear-inducing videos. There was no comparable impairment in behavioral data (emotion report, valence, and arousal ratings). The results point to a defective modulation of sympathetic responses during emotional stimulation in patients with LE, probably due to impaired functioning of the amygdala.

No MeSH data available.


Related in: MedlinePlus