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Impaired Autonomic Responses to Emotional Stimuli in Autoimmune Limbic Encephalitis.

Schröder O, Schriewer E, Golombeck KS, Kürten J, Lohmann H, Schwindt W, Wiendl H, Bruchmann M, Melzer N, Straube T - Front Neurol (2015)

Bottom Line: The amygdala constitutes a brain area substantial for processing of emotional, especially fear-related signals.There was no comparable impairment in behavioral data (emotion report, valence, and arousal ratings).The results point to a defective modulation of sympathetic responses during emotional stimulation in patients with LE, probably due to impaired functioning of the amygdala.

View Article: PubMed Central - PubMed

Affiliation: Institute of Medical Psychology and Systems Neuroscience, University of Muenster , Muenster , Germany.

ABSTRACT
Limbic encephalitis (LE) is an autoimmune-mediated disorder that affects structures of the limbic system, in particular, the amygdala. The amygdala constitutes a brain area substantial for processing of emotional, especially fear-related signals. The amygdala is also involved in neuroendocrine and autonomic functions, including skin conductance responses (SCRs) to emotionally arousing stimuli. This study investigates behavioral and autonomic responses to discrete emotion evoking and neutral film clips in a patient suffering from LE associated with contactin-associated protein-2 (CASPR2) antibodies as compared to a healthy control group. Results show a lack of SCRs in the patient while watching the film clips, with significant differences compared to healthy controls in the case of fear-inducing videos. There was no comparable impairment in behavioral data (emotion report, valence, and arousal ratings). The results point to a defective modulation of sympathetic responses during emotional stimulation in patients with LE, probably due to impaired functioning of the amygdala.

No MeSH data available.


Related in: MedlinePlus

R.B.’s z-transformed valence (A) and arousal (B) ratings vs. healthy controls (zero line represents control group’s mean; gray zone indicates the 95% confidence interval). Significant differences (i.e., /z/ ≥ 1.96) are marked with a red box.
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Figure 2: R.B.’s z-transformed valence (A) and arousal (B) ratings vs. healthy controls (zero line represents control group’s mean; gray zone indicates the 95% confidence interval). Significant differences (i.e., /z/ ≥ 1.96) are marked with a red box.

Mentions: Results of both valence and arousal ratings are visualized in Figure 2.


Impaired Autonomic Responses to Emotional Stimuli in Autoimmune Limbic Encephalitis.

Schröder O, Schriewer E, Golombeck KS, Kürten J, Lohmann H, Schwindt W, Wiendl H, Bruchmann M, Melzer N, Straube T - Front Neurol (2015)

R.B.’s z-transformed valence (A) and arousal (B) ratings vs. healthy controls (zero line represents control group’s mean; gray zone indicates the 95% confidence interval). Significant differences (i.e., /z/ ≥ 1.96) are marked with a red box.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4663278&req=5

Figure 2: R.B.’s z-transformed valence (A) and arousal (B) ratings vs. healthy controls (zero line represents control group’s mean; gray zone indicates the 95% confidence interval). Significant differences (i.e., /z/ ≥ 1.96) are marked with a red box.
Mentions: Results of both valence and arousal ratings are visualized in Figure 2.

Bottom Line: The amygdala constitutes a brain area substantial for processing of emotional, especially fear-related signals.There was no comparable impairment in behavioral data (emotion report, valence, and arousal ratings).The results point to a defective modulation of sympathetic responses during emotional stimulation in patients with LE, probably due to impaired functioning of the amygdala.

View Article: PubMed Central - PubMed

Affiliation: Institute of Medical Psychology and Systems Neuroscience, University of Muenster , Muenster , Germany.

ABSTRACT
Limbic encephalitis (LE) is an autoimmune-mediated disorder that affects structures of the limbic system, in particular, the amygdala. The amygdala constitutes a brain area substantial for processing of emotional, especially fear-related signals. The amygdala is also involved in neuroendocrine and autonomic functions, including skin conductance responses (SCRs) to emotionally arousing stimuli. This study investigates behavioral and autonomic responses to discrete emotion evoking and neutral film clips in a patient suffering from LE associated with contactin-associated protein-2 (CASPR2) antibodies as compared to a healthy control group. Results show a lack of SCRs in the patient while watching the film clips, with significant differences compared to healthy controls in the case of fear-inducing videos. There was no comparable impairment in behavioral data (emotion report, valence, and arousal ratings). The results point to a defective modulation of sympathetic responses during emotional stimulation in patients with LE, probably due to impaired functioning of the amygdala.

No MeSH data available.


Related in: MedlinePlus