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Neural Substrates of Sexual Desire in Individuals with Problematic Hypersexual Behavior.

Seok JW, Sohn JH - Front Behav Neurosci (2015)

Bottom Line: In addition, the hemodynamic patterns in the activated areas differed between the groups.Consistent with the findings of brain imaging studies of substance and behavior addiction, individuals with the behavioral characteristics of PHB and enhanced desire exhibited altered activation in the prefrontal cortex and subcortical regions.In conclusion, our results will help to characterize the behaviors and associated neural mechanisms of individuals with PHB.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychology, Brain Research Institute, Chungnam National University Daejeon, South Korea.

ABSTRACT
Studies on the characteristics of individuals with hypersexual disorder have been accumulating due to increasing concerns about problematic hypersexual behavior (PHB). Currently, relatively little is known about the underlying behavioral and neural mechanisms of sexual desire. Our study aimed to investigate the neural correlates of sexual desire with event-related functional magnetic resonance imaging (fMRI). Twenty-three individuals with PHB and 22 age-matched healthy controls were scanned while they passively viewed sexual and nonsexual stimuli. The subjects' levels of sexual desire were assessed in response to each sexual stimulus. Relative to controls, individuals with PHB experienced more frequent and enhanced sexual desire during exposure to sexual stimuli. Greater activation was observed in the caudate nucleus, inferior parietal lobe, dorsal anterior cingulate gyrus, thalamus, and dorsolateral prefrontal cortex in the PHB group than in the control group. In addition, the hemodynamic patterns in the activated areas differed between the groups. Consistent with the findings of brain imaging studies of substance and behavior addiction, individuals with the behavioral characteristics of PHB and enhanced desire exhibited altered activation in the prefrontal cortex and subcortical regions. In conclusion, our results will help to characterize the behaviors and associated neural mechanisms of individuals with PHB.

No MeSH data available.


Related in: MedlinePlus

Results of the correlation analysis. Left, functional magnetic resonance imaging (fMRI) correlational analysis. The regions showing significant correlation between the brain activity during sexual desire and the Sexual Addiction Screening Test-R (SAST-R) scores (p < 0.001, uncorrected). Right, linear relationship between the percent signal changes extracted from each area and sexual severity scores [i.e., SAST-R and Hypersexual Behavior Inventory (HBI) scores]. The x-axis shows the sexual severity scores, and the y-axis represents the percent signal change. (A) Bilateral thalamus (MNI coordinate; x = 4, y = −32, z = 6) (B) Right dorsolateral prefrontal cortex (MNI coordinate; x = 56, y = 8, z = 22).
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Figure 4: Results of the correlation analysis. Left, functional magnetic resonance imaging (fMRI) correlational analysis. The regions showing significant correlation between the brain activity during sexual desire and the Sexual Addiction Screening Test-R (SAST-R) scores (p < 0.001, uncorrected). Right, linear relationship between the percent signal changes extracted from each area and sexual severity scores [i.e., SAST-R and Hypersexual Behavior Inventory (HBI) scores]. The x-axis shows the sexual severity scores, and the y-axis represents the percent signal change. (A) Bilateral thalamus (MNI coordinate; x = 4, y = −32, z = 6) (B) Right dorsolateral prefrontal cortex (MNI coordinate; x = 56, y = 8, z = 22).

Mentions: The correlation analysis of the regions that were related to the SAST-R score demonstrated that the right thalamus and DLPFC (BA 9) were correlated with the SAST-R scores (p < 0.001, uncorrected) in the PHB group during the exposure to sexual stimuli, as shown in Table 4. The results of the follow-up analysis showed that the percent signal change that was extracted from the right thalamus and DLPFC correlated significantly with the severity of hypersexuality, as shown in Figure 4. The percent signal changes in the right thalamus and right DLPFC correlated positively with the SAST-R scores in the PHB group during exposure to sexual stimuli (right thalamus: r = 0.74, n = 23, p < 0.01; right DLPFC: r = 0.63, n = 23, p < 0.01). In addition, the percent signal changes in the right DLPFC and right thalamus were positively related to the HBI scores in the PHB group (right thalamus: r = 0.65, n = 23, p < 0.01; right DLPFC: r = 0.53, n = 23, p < 0.01), as shown in Figure 4.


Neural Substrates of Sexual Desire in Individuals with Problematic Hypersexual Behavior.

Seok JW, Sohn JH - Front Behav Neurosci (2015)

Results of the correlation analysis. Left, functional magnetic resonance imaging (fMRI) correlational analysis. The regions showing significant correlation between the brain activity during sexual desire and the Sexual Addiction Screening Test-R (SAST-R) scores (p < 0.001, uncorrected). Right, linear relationship between the percent signal changes extracted from each area and sexual severity scores [i.e., SAST-R and Hypersexual Behavior Inventory (HBI) scores]. The x-axis shows the sexual severity scores, and the y-axis represents the percent signal change. (A) Bilateral thalamus (MNI coordinate; x = 4, y = −32, z = 6) (B) Right dorsolateral prefrontal cortex (MNI coordinate; x = 56, y = 8, z = 22).
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Figure 4: Results of the correlation analysis. Left, functional magnetic resonance imaging (fMRI) correlational analysis. The regions showing significant correlation between the brain activity during sexual desire and the Sexual Addiction Screening Test-R (SAST-R) scores (p < 0.001, uncorrected). Right, linear relationship between the percent signal changes extracted from each area and sexual severity scores [i.e., SAST-R and Hypersexual Behavior Inventory (HBI) scores]. The x-axis shows the sexual severity scores, and the y-axis represents the percent signal change. (A) Bilateral thalamus (MNI coordinate; x = 4, y = −32, z = 6) (B) Right dorsolateral prefrontal cortex (MNI coordinate; x = 56, y = 8, z = 22).
Mentions: The correlation analysis of the regions that were related to the SAST-R score demonstrated that the right thalamus and DLPFC (BA 9) were correlated with the SAST-R scores (p < 0.001, uncorrected) in the PHB group during the exposure to sexual stimuli, as shown in Table 4. The results of the follow-up analysis showed that the percent signal change that was extracted from the right thalamus and DLPFC correlated significantly with the severity of hypersexuality, as shown in Figure 4. The percent signal changes in the right thalamus and right DLPFC correlated positively with the SAST-R scores in the PHB group during exposure to sexual stimuli (right thalamus: r = 0.74, n = 23, p < 0.01; right DLPFC: r = 0.63, n = 23, p < 0.01). In addition, the percent signal changes in the right DLPFC and right thalamus were positively related to the HBI scores in the PHB group (right thalamus: r = 0.65, n = 23, p < 0.01; right DLPFC: r = 0.53, n = 23, p < 0.01), as shown in Figure 4.

Bottom Line: In addition, the hemodynamic patterns in the activated areas differed between the groups.Consistent with the findings of brain imaging studies of substance and behavior addiction, individuals with the behavioral characteristics of PHB and enhanced desire exhibited altered activation in the prefrontal cortex and subcortical regions.In conclusion, our results will help to characterize the behaviors and associated neural mechanisms of individuals with PHB.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychology, Brain Research Institute, Chungnam National University Daejeon, South Korea.

ABSTRACT
Studies on the characteristics of individuals with hypersexual disorder have been accumulating due to increasing concerns about problematic hypersexual behavior (PHB). Currently, relatively little is known about the underlying behavioral and neural mechanisms of sexual desire. Our study aimed to investigate the neural correlates of sexual desire with event-related functional magnetic resonance imaging (fMRI). Twenty-three individuals with PHB and 22 age-matched healthy controls were scanned while they passively viewed sexual and nonsexual stimuli. The subjects' levels of sexual desire were assessed in response to each sexual stimulus. Relative to controls, individuals with PHB experienced more frequent and enhanced sexual desire during exposure to sexual stimuli. Greater activation was observed in the caudate nucleus, inferior parietal lobe, dorsal anterior cingulate gyrus, thalamus, and dorsolateral prefrontal cortex in the PHB group than in the control group. In addition, the hemodynamic patterns in the activated areas differed between the groups. Consistent with the findings of brain imaging studies of substance and behavior addiction, individuals with the behavioral characteristics of PHB and enhanced desire exhibited altered activation in the prefrontal cortex and subcortical regions. In conclusion, our results will help to characterize the behaviors and associated neural mechanisms of individuals with PHB.

No MeSH data available.


Related in: MedlinePlus