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Neural Substrates of Sexual Desire in Individuals with Problematic Hypersexual Behavior.

Seok JW, Sohn JH - Front Behav Neurosci (2015)

Bottom Line: In addition, the hemodynamic patterns in the activated areas differed between the groups.Consistent with the findings of brain imaging studies of substance and behavior addiction, individuals with the behavioral characteristics of PHB and enhanced desire exhibited altered activation in the prefrontal cortex and subcortical regions.In conclusion, our results will help to characterize the behaviors and associated neural mechanisms of individuals with PHB.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychology, Brain Research Institute, Chungnam National University Daejeon, South Korea.

ABSTRACT
Studies on the characteristics of individuals with hypersexual disorder have been accumulating due to increasing concerns about problematic hypersexual behavior (PHB). Currently, relatively little is known about the underlying behavioral and neural mechanisms of sexual desire. Our study aimed to investigate the neural correlates of sexual desire with event-related functional magnetic resonance imaging (fMRI). Twenty-three individuals with PHB and 22 age-matched healthy controls were scanned while they passively viewed sexual and nonsexual stimuli. The subjects' levels of sexual desire were assessed in response to each sexual stimulus. Relative to controls, individuals with PHB experienced more frequent and enhanced sexual desire during exposure to sexual stimuli. Greater activation was observed in the caudate nucleus, inferior parietal lobe, dorsal anterior cingulate gyrus, thalamus, and dorsolateral prefrontal cortex in the PHB group than in the control group. In addition, the hemodynamic patterns in the activated areas differed between the groups. Consistent with the findings of brain imaging studies of substance and behavior addiction, individuals with the behavioral characteristics of PHB and enhanced desire exhibited altered activation in the prefrontal cortex and subcortical regions. In conclusion, our results will help to characterize the behaviors and associated neural mechanisms of individuals with PHB.

No MeSH data available.


Related in: MedlinePlus

The event-related paradigm for sexual desire.
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Figure 1: The event-related paradigm for sexual desire.

Mentions: For the fMRI experimental paradigm, brief instructions about the experiment were given for 6 s at the beginning of the experiment, which was followed by the random presentation of either sexual or nonsexual stimuli for 5 s each. Each interstimulus interval was 7–13 s (average, 10 s) to help the participant to return to their baseline state. To keep the participants focused on the stimuli, they were asked to press the response button when an unexpected target was presented for approximately 500 ms for a total of 12 times during any interval. The total time required for the experiment was 8 min and 48 s (Figure 1).


Neural Substrates of Sexual Desire in Individuals with Problematic Hypersexual Behavior.

Seok JW, Sohn JH - Front Behav Neurosci (2015)

The event-related paradigm for sexual desire.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4663274&req=5

Figure 1: The event-related paradigm for sexual desire.
Mentions: For the fMRI experimental paradigm, brief instructions about the experiment were given for 6 s at the beginning of the experiment, which was followed by the random presentation of either sexual or nonsexual stimuli for 5 s each. Each interstimulus interval was 7–13 s (average, 10 s) to help the participant to return to their baseline state. To keep the participants focused on the stimuli, they were asked to press the response button when an unexpected target was presented for approximately 500 ms for a total of 12 times during any interval. The total time required for the experiment was 8 min and 48 s (Figure 1).

Bottom Line: In addition, the hemodynamic patterns in the activated areas differed between the groups.Consistent with the findings of brain imaging studies of substance and behavior addiction, individuals with the behavioral characteristics of PHB and enhanced desire exhibited altered activation in the prefrontal cortex and subcortical regions.In conclusion, our results will help to characterize the behaviors and associated neural mechanisms of individuals with PHB.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychology, Brain Research Institute, Chungnam National University Daejeon, South Korea.

ABSTRACT
Studies on the characteristics of individuals with hypersexual disorder have been accumulating due to increasing concerns about problematic hypersexual behavior (PHB). Currently, relatively little is known about the underlying behavioral and neural mechanisms of sexual desire. Our study aimed to investigate the neural correlates of sexual desire with event-related functional magnetic resonance imaging (fMRI). Twenty-three individuals with PHB and 22 age-matched healthy controls were scanned while they passively viewed sexual and nonsexual stimuli. The subjects' levels of sexual desire were assessed in response to each sexual stimulus. Relative to controls, individuals with PHB experienced more frequent and enhanced sexual desire during exposure to sexual stimuli. Greater activation was observed in the caudate nucleus, inferior parietal lobe, dorsal anterior cingulate gyrus, thalamus, and dorsolateral prefrontal cortex in the PHB group than in the control group. In addition, the hemodynamic patterns in the activated areas differed between the groups. Consistent with the findings of brain imaging studies of substance and behavior addiction, individuals with the behavioral characteristics of PHB and enhanced desire exhibited altered activation in the prefrontal cortex and subcortical regions. In conclusion, our results will help to characterize the behaviors and associated neural mechanisms of individuals with PHB.

No MeSH data available.


Related in: MedlinePlus