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SLE: Another Autoimmune Disorder Influenced by Microbes and Diet?

Mu Q, Zhang H, Luo XM - Front Immunol (2015)

Bottom Line: In the past decade, a growing body of evidence has indicated an important role of gut microbes in the development of autoimmune diseases, including type 1 diabetes, rheumatoid arthritis, and multiple sclerosis.However, such knowledge on SLE is little, though we have already known that environmental factors can trigger the development of lupus.Several recent studies have suggested that alterations of the gut microbial composition may be correlated with SLE disease manifestations, while the exact roles of either symbiotic or pathogenic microbes in this disease remain to be explored.

View Article: PubMed Central - PubMed

Affiliation: Department of Biomedical Sciences and Pathobiology, Virginia Tech , Blacksburg, VA , USA.

ABSTRACT
Systemic lupus erythematosus (SLE) is a multi-system autoimmune disease. Despite years of study, the etiology of SLE is still unclear. Both genetic and environmental factors have been implicated in the disease mechanisms. In the past decade, a growing body of evidence has indicated an important role of gut microbes in the development of autoimmune diseases, including type 1 diabetes, rheumatoid arthritis, and multiple sclerosis. However, such knowledge on SLE is little, though we have already known that environmental factors can trigger the development of lupus. Several recent studies have suggested that alterations of the gut microbial composition may be correlated with SLE disease manifestations, while the exact roles of either symbiotic or pathogenic microbes in this disease remain to be explored. Elucidation of the roles of gut microbes - as well as the roles of diet that can modulate the composition of gut microbes - in SLE will shed light on how this autoimmune disorder develops, and provide opportunities for improved biomarkers of the disease and the potential to probe new therapies. In this review, we aim to compile the available evidence on the contributions of diet and gut microbes to SLE occurrence and pathogenesis.

No MeSH data available.


Related in: MedlinePlus

Emerging evidences point to a potential link between SLE and microbiota.
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Figure 1: Emerging evidences point to a potential link between SLE and microbiota.

Mentions: The significance of symbiotic microbiota in the development of T1D has been shown in non-obese diabetic mice, which spontaneously develop T1D with a bias toward females (11, 12). The function of microbiota in T1D is found to be highly associated with sex hormones. Fecal transplant of male gut microbiota to female mice ameliorated the disease and increased testosterone. For SLE, although the initial comparison between lupus-prone mice in germ-free vs. conventional housing conditions showed no difference in disease severity (140), emerging evidences in both SLE patients and lupus-prone mice point to a potential link between lupus and microbiota (Figure 1).


SLE: Another Autoimmune Disorder Influenced by Microbes and Diet?

Mu Q, Zhang H, Luo XM - Front Immunol (2015)

Emerging evidences point to a potential link between SLE and microbiota.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4663251&req=5

Figure 1: Emerging evidences point to a potential link between SLE and microbiota.
Mentions: The significance of symbiotic microbiota in the development of T1D has been shown in non-obese diabetic mice, which spontaneously develop T1D with a bias toward females (11, 12). The function of microbiota in T1D is found to be highly associated with sex hormones. Fecal transplant of male gut microbiota to female mice ameliorated the disease and increased testosterone. For SLE, although the initial comparison between lupus-prone mice in germ-free vs. conventional housing conditions showed no difference in disease severity (140), emerging evidences in both SLE patients and lupus-prone mice point to a potential link between lupus and microbiota (Figure 1).

Bottom Line: In the past decade, a growing body of evidence has indicated an important role of gut microbes in the development of autoimmune diseases, including type 1 diabetes, rheumatoid arthritis, and multiple sclerosis.However, such knowledge on SLE is little, though we have already known that environmental factors can trigger the development of lupus.Several recent studies have suggested that alterations of the gut microbial composition may be correlated with SLE disease manifestations, while the exact roles of either symbiotic or pathogenic microbes in this disease remain to be explored.

View Article: PubMed Central - PubMed

Affiliation: Department of Biomedical Sciences and Pathobiology, Virginia Tech , Blacksburg, VA , USA.

ABSTRACT
Systemic lupus erythematosus (SLE) is a multi-system autoimmune disease. Despite years of study, the etiology of SLE is still unclear. Both genetic and environmental factors have been implicated in the disease mechanisms. In the past decade, a growing body of evidence has indicated an important role of gut microbes in the development of autoimmune diseases, including type 1 diabetes, rheumatoid arthritis, and multiple sclerosis. However, such knowledge on SLE is little, though we have already known that environmental factors can trigger the development of lupus. Several recent studies have suggested that alterations of the gut microbial composition may be correlated with SLE disease manifestations, while the exact roles of either symbiotic or pathogenic microbes in this disease remain to be explored. Elucidation of the roles of gut microbes - as well as the roles of diet that can modulate the composition of gut microbes - in SLE will shed light on how this autoimmune disorder develops, and provide opportunities for improved biomarkers of the disease and the potential to probe new therapies. In this review, we aim to compile the available evidence on the contributions of diet and gut microbes to SLE occurrence and pathogenesis.

No MeSH data available.


Related in: MedlinePlus